A5100436154- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Inflammatory Biomarkers in Disease Prognosis
- Single-cell and spatial transcriptomics
- Breast Cancer Treatment Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Sepsis Diagnosis and Treatment
- Autophagy in Disease and Therapy
- Peroxisome Proliferator-Activated Receptors
- Cancer, Stress, Anesthesia, and Immune Response
- Ureteral procedures and complications
- Chemokine receptors and signaling
- Adipokines, Inflammation, and Metabolic Diseases
- CAR-T cell therapy research
- Dietary Effects on Health
- interferon and immune responses
Beckman Research Institute
2020-2024
City of Hope
2020-2024
Shenzhen University Health Science Center
2024
Tianjin Medical University
2022-2024
Second Hospital of Tianjin Medical University
2022-2024
Shanghai Public Health Clinical Center
2023
Anhui University of Traditional Chinese Medicine
2022-2023
Nanjing University of Chinese Medicine
2023
West Virginia University
2023
Jiangsu Provincial Academy of Traditional Chinese Medicine
2023
The poor prognosis of esophageal squamous cell carcinoma (ESCC) highlights the need for novel strategies against this disease. Our previous study suggested involvement CCL2 and tumor associated macrophages (TAMs) in carcinogenesis. Despite recognition TAMs as a promising target cancer treatment, mechanisms underlying its infiltration, activation tumor-promotive function ESCC remain unknown.Human tissue array TCGA database were used to evaluate clinical relevance ESCC. F344 rats C57BL/6 mice...
Tumor-associated macrophages (TAMs) are the predominant cells that express programmed cell death ligand 1 (PD-L1) within human tumors in addition to cancer cells, and PD-L1
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function tumor suppressing factor via modulation immune cell-tumor cell interaction. To date, PD-1/PD-L1 have been approved for the treatment specific types tumors and obtained good clinical efficacy. However, patients with osteosarcoma showed poor response to anti-PD-1/PD-L1 therapy, mechanism which is not well understood. In this study, we found tissues were heavily infiltrated by myeloid-derived...
BackgroundIt is increasingly recognized that cancer progression induces systemic immune changes in the host. Alterations number and function of cells have been identified patients' peripheral blood lymphoid organs. Recently, we found dysregulated cytokine signaling T from breast (BC) patients, even those with localized disease.MethodsWe used phosphoflow cytometry to determine clinical significance responsiveness monocytes non-metastatic BC patients at diagnosis. We also examined correlation...
Atherosclerosis (AS) in diabetic patients is often associated with low stability, which might be largely attributed to unfavorable macrophage polarization and increased inflammatory response induced by hyperglycaemia. Ginsenoside Rg3 one of the main active principles Panax Ginseng, has been reported a natural ligand peroxisome proliferator-activated receptor-gamma (PPARγ), key nuclear transcriptional factor involved inflammation differentiation. However, it remains unclear if could exert...
Purpose: Prostate cancer (PCa) is often considered as a âcoldâ tumor with low responsiveness to immunotherapy. Recent evidence suggests the activation of specific immune cells, such tumor-associated macrophages (TAMs), could potentially influence efficacy immunotherapy in PCa. However, relationship between TAMs and PD-L1, significant regulator immunotherapy, within PCa remains unexplored. Methods: In this study, we assessed TAM infiltration PD-L1 expression levels local cohort 95 tissue...
Drug Delivery System was constructed using dopamine-coated organic-inorganic hybrid hollow mesoporous organic silica nanoparticles (HMON-PDA) as drug carriers and salvianolic acid B (SAB) a model drug. Then, we further investigated whether it can inhibit lung metastasis of breast cancer by inhibiting cancer-associated fibroblasts (CAFs).The (HMON) were prepared. The particle size, zeta potential, polydispersion coefficient characterized. High-performance liquid chromatography used to...
// Encheng Li 1,* , Zhiyun Xu Hui Zhao 2,* Sun 1 Lei Wang 3 Zhe Guo Yang Zhancheng Gao 4 and Qi Department of Respiratory Medicine, The Second Affiliated Hospital, Dalian Medical University, Dalian, China 2 Physical Examination Center, Liaoning Provincial Key Laboratory for Micro/Nano Technology, University & Critical Care People's Hospital Peking Beijing, * These authors contributed equally to this work Correspondence to: Wang, email: Gao, Keywords : Macrophages, malignant transformation,...
Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by downregulating T cell activation. The most studied CTLA-4 +49A/G polymorphism has been associated with various cancers risks. However, little known about the association between and bladder cancer risk. A hospital-based case–control study was conducted in 300 patients healthy controls matched age sex. genotyped using polymerase chain reaction-restriction fragment length...
Recent research shows that tumor-associated macrophages (TAMs) are the primary consumers of glucose in tumor tissue, surpassing cells. Our previous studies revealed inhibiting uptake impairs survival and tumor-promoting function hypoxic TAMs, suggesting reduction by energy restriction (calorie or short-term fasting) may has a significant impact on TAMs. The purpose this study is to verify effect fasting-mimicking diet (FMD) determine whether FMD synergizes with anti-angiogenic drug apatinib...
In response to external stimuli during immune responses, monocytes can have multifaceted roles such as pathogen clearance and tissue repair. However, aberrant control of monocyte activation result in chronic inflammation subsequent damage. Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces differentiation into a heterogenous population monocyte-derived dendritic cells (moDCs) macrophages. the downstream molecular signals that dictate under pathological conditions is...
This study aimed to investigate the effect of N-acetylcysteine (NAC) on indomethacin (IDMT)-induced intestinal injury in a piglet model and explore underlying molecular mechanisms. Piglets were randomly divided into 3 treatment groups: (1) control group; (2) IDMT (3) NAC+IDMT group. The results showed that NAC administration significantly increased average daily gain piglets, attenuated intestine hyperemia, restored normal jejunal morphology. Further studies indicated plasma citrulline...
Abstract Differential body responses to various stresses, infectious or noninfectious, govern clinical outcomes ranging from asymptoma death. However, the common molecular and cellular nature of stress responsome across different stimuli is not described. In this study, we compared expression behaviors between burns COVID-19 infection by choosing transcriptome peripheral blood related patients as analytic target since cells reflect systemic landscape immune homeostasis. We identified an...