A5100367070- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Invertebrate Immune Response Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Inflammation biomarkers and pathways
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Tissue Engineering and Regenerative Medicine
- Neurobiology and Insect Physiology Research
- Reproductive System and Pregnancy
- Sepsis Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Drug Transport and Resistance Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
Jiangsu University
2016-2025
Jiangnan University
2024-2025
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Sun Yat-sen University
2022-2024
Ningbo University
2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
University of Chicago
2017-2024
Jiangning District of Nanjing Chinese Medicine Hospital
2023-2024
Nanjing University of Chinese Medicine
2023-2024
Abstract Tumor-associated macrophages (TAM) are important tumor-promoting cells. However, the mechanisms underlying how tumor and its microenvironment reprogram these cells remain elusive. Here we report that lipids play a crucial role in generating TAMs (TME). Macrophages from both human murine tissues were enriched with due to increased lipid uptake by macrophages. expressed elevated levels of scavenger receptor CD36, accumulated lipids, used fatty acid oxidation (FAO) instead glycolysis...
Abstract Pathogenic intracellular bacteria often hijack macrophages for their propagation. The infected release IL-1β and IL-18 simultaneously commit suicide, which is called pyroptosis; both responses require caspase-1. Here, we found that pyroptotic cells induced by microbial infection were efficiently engulfed human monocytic THP-1-cell-derived or mouse peritoneal macrophages. This engulfment was inhibited the D89E mutant of milk fat globule (MFG) epidermal growth factor (EGF) 8 (MFG-E8;...
Spinal cord injury (SCI) is a serious, prolonged, and irreversible with few therapeutic options. Albiflorin (AF) possesses powerful pharmacodynamic properties exerts protective effects against neuroinflammation. However, no research has examined the neuroprotective effect of AF following SCI. Rats were received laminectomy to establish SCI animal model treated (20 mg/kg 40 mg/kg). Behavioral experiments conducted assess impacts on motor function after in rats. Hematoxylin-eosin (HE)...
Surface-displayed whole-cell biocatalysis offers significant advantages over traditional intracellular enzyme-based methods but faces challenges in complex multienzyme processes and low efficiency. We present Scaffold-Mediated Assembly Regulation Tool (SMART), a programmable platform for dynamic control of biocatalysts on Corynebacterium glutamicum surfaces. SMART integrates orthogonal cross-linked scaffolds with the twin Catcher/Tag pairs (SpyCatcher/SpyTag SnoopCatcher/SnoopTag),...
Immunosuppression in response to severe sepsis remains a serious human health concern. Evidence of sepsis-induced immunosuppression includes impaired T lymphocyte function, depletion or exhaustion, increased susceptibility opportunistic nosocomial infection, and imbalanced cytokine secretion. CD4 cells play critical role cellular humoral immune responses during sepsis. Here, using an RNA sequencing assay, we found that the expression cell-containing immunoglobulin mucin domain-3 (Tim-3) on...
Postimplantation uterine development involves extensive stromal cell proliferation and decidual transformation with polyploidization, which is essential for normal pregnancy establishment. However, it remains largely unknown how versus polyploidization differentially regulated during decidualization. Utilizing Wnt6-mutant mice, we show here that Wnt6 deficiency impairs without much adverse effects on polyploidization. Applying a primary culture model, further reveal loss of prolongs the...
Cannabinoid receptor type 2 (CB2) activation is recently reported to promote proliferation of some types resident stem cells (e.g., hematopoietic stem/progenitor cell or neural progenitor cell). Resident cardiac (CPC) and are crucial for endogenous regeneration repair after myocardial infarction (MI). This study aims explore the role possible mechanisms CB2 in enhancing repair. Our results revealed that agonist AM1241 can significantly increase CPCs by c-kit Runx1 staining ischemic...
Insects rely on their sense of smell to locate food and hosts, find mates select sites for laying eggs. Use volatile compounds, such as essential oils (EOs), repel insect pests disrupt olfaction-driven behaviors has great practical significance in integrated pest management. However, our knowledge the olfaction-based mechanisms EO repellency is quite limited.We evaluated peppermint oil nine plant components Drosophila melanogaster, a model olfaction study, D. suzukii, major fruit crop pest....
A dynamic nano-coordination photothermal hydrogel was successfully used as a highly adaptable and antibacterial wound dressing for infected skin injuries.
Lung metastasis is a critical cause of cancer mortality and its therapy largely challenged by the limited drug delivery efficiency robust immunosuppression in metastatic tumors. Herein, we designed spatial-drug-laden M1 macrophage system with liposomal R848 inside fibroblast activation protein protease (FAP)-sensitive phospholipid-DM4 conjugate on membrane (RDM). RDM could preferentially accumulate at lesions lungs responsively release therapeutic agents as free molecules or drug-loaded...