A5100415518- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Cholesterol and Lipid Metabolism
- interferon and immune responses
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Fibroblast Growth Factor Research
- Inflammasome and immune disorders
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Phagocytosis and Immune Regulation
- Growth Hormone and Insulin-like Growth Factors
- Microbial infections and disease research
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Systems and Laser Technology
- Pediatric health and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Actinomycetales infections and treatment
Hebei Medical University
2023-2025
Second Hospital of Hebei Medical University
2025
Southern Medical University
2019-2024
Nanfang Hospital
2019-2024
Northeastern University
2020-2024
Key Laboratory of Guangdong Province
2024
Huazhong Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Tianjin Medical University
2021-2024
Wuhan Institute of Virology
2020-2024
Abstract Background Atherosclerosis (AS), the main pathological basis of life‐threatening cardiovascular disease, is essentially caused by chronic macrophage inflammation. Overexpression proline/serine‐rich coiled‐coil protein 1 (PSRC1) reduces inflammatory responses and delays AS development. However, exact mechanism PSRC1 unclear. Methods Proteins interacting with were screened proteomics in RAW264.7 cells, followed RT‒qPCR, immunoprecipitation immunofluorescence to explore specific...
The one-carbon metabolism enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is involved in the regulation of tumor oncogenesis and immune cell functions, but whether it can contribute to macrophage polarization remains elusive. Here, we show that MTHFD2 suppresses interferon-γ-activated macrophages (M(IFN-γ)) enhances interleukin-4-activated (M(IL-4)) both vitro vivo. Mechanistically, interacts with phosphatase tensin homolog (PTEN) suppress PTEN's phosphatidylinositol...
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due its metabolic benefits. However, effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in animal models. The present study was designed investigate atherosclerosis apolipoprotein E-deficient (Apoe -/- ) mice. Eleven-week-old male Apoe mice fed with Western diet (WD) were randomly grouped into ad libitum (AL) group...
Neoantigen-based cancer vaccine therapy is a breakthrough in the field of immunotherapy. However, it difficult for vaccines against neoantigens to overcome immunosuppressive microenvironment, where tumor-associated macrophages (TAMs) play significant role. Herein, we report an iron oxide nanoparticle modified with hyaluronic acid and mannose reshape tumor microenvironment by targeting repolarizing TAMs from protumor M2 antitumor M1 phenotype. Mannose decoration could confer...
BackgroundLive attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust sustained immune response as well confer long-term protection. However, safety concerns is one of the major obstacles for LAVs development. In an effort achieve optimal balance between immunogenicity safety, researchers currently taken different strategies development LAVs.MethodsWe constructed novel infectious self-propagating hybrid replicon particle (PRP), VEEV-RABV-G, through...
Lung cancer is one of the most common malignancy worldwide and causes estimated 1.6 million deaths each year. Cancer immunosurveillance has been found to play an important role in lung may be related with its prognosis. KLRK1, encoding NKG2D, a homodimeric lectin-like receptor. However, there not research KLRK1 as biomarker cancer. Data including patients` clinical characteristics RNAseq information from TCGA were downloaded. A total 1019 patients included this study, among which 407 female...
Background Ovarian cancer (OC) is highly heterogeneous and has a poor prognosis. A better understanding of OC biology could provide more effective therapeutic paradigms for different subtypes. Methods To reveal the heterogeneity T cell-associated subclusters in OC, we performed an in-depth analysis single-cell transcriptional profiles clinical information patients with OC. Then, above results were verified by qPCR flow cytometry examine. Results After screening threshold, total 85,699 cells...
Riboflavin kinase (RFK) is essential in riboflavin metabolism, converting to flavin mononucleotide (FMN), which further processed adenine dinucleotide (FAD). While RFK enhances macrophage phagocytosis of Listeria monocytogenes, its role polarization not well understood. Our study reveals that deficiency impairs M(IFN-γ) and promotes M(IL-4) polarization, both vitro vivo. Mechanistically, interacts with inducible nitric oxide (NO) synthase (iNOS), requires FMN FAD as cofactors for activation,...
Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles the regulation of lipid metabolism and response. However, little known about functions SULT2B1b ox-LDL-induced inflammation macrophages. In this study, after treatment with either ox-LDL alone or combined transfection siRNAs targeting SULT2B1b, IL-6, TNF-α, NF-κB, IKKβ...
Abstract The current main treatment for coronary artery disease (CAD) is to reduce low-density lipoprotein cholesterol (LDL-C) by statins, which could decrease the incidence of major adverse cardiovascular events (MACEs) 30%. However, many residual risks still remain. To clarify mechanism involved, we studied patients with acute myocardial infarction (AMI) low LDL-C levels. Lymphocytes were isolated, and it was found that despite no difference in plasma level, lymphocyte content higher AMI...
Bovine parainfluenza virus type 3 (BPIV-3) is one of the major pathogens bovine respiratory disease complex (BRDC). BPIV-3 surveillance in China has been quite limited. In this study, we used PCR to test 302 cattle China, and found that positive rate was 4.64% herd-level 13.16%. Six BPIV-3C strains were isolated confirmed by electron microscopy, their titers determined. Three sequenced next-generation sequencing (NGS). Phylogenetic analyses showed all isolates most closely related strain...
Purpose The purpose of this study was to investigate the relationship between serum immunoglobulin M (IgM) and severity coronary artery disease in Chinese patients who underwent angiography. Methods A total 2,045 angiography (CAG) from March 2017 2020 at Beijing Hospital were included study. Serum IgM concentration biochemical indicators measured before (CAG). triquartile levels baseline population analysed. Spearman rank correlation used analyse association traditional risk factors for...