A5103086182- Sarcoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Gastrointestinal Tumor Research and Treatment
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Sulfur Compounds in Biology
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Cardiac tumors and thrombi
- Urologic and reproductive health conditions
- Drug Transport and Resistance Mechanisms
- Barrier Structure and Function Studies
- Bone Tumor Diagnosis and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Lymphoma Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Hedgehog Signaling Pathway Studies
- Neurofibromatosis and Schwannoma Cases
Peking University First Hospital
2016-2024
Peking University
2016-2024
XinHua Hospital
2022-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Qingdao University
2021-2024
Guangzhou University
2023
Weihai Chest Hospital
2022
Society of Gastroenterology Nurses and Associates
2020
Substance Abuse Free Environment
2020
Recently, long noncoding RNA (lncRNA) H19 has been reported to be related with VDR signaling and the development of inflammatory diseases including osteoarthritis. The aim this study was investigate correlation between expression level in ulcerative colitis (UC) tissues effect overexpression on intestinal epithelial barrier function. H19, miR-675-5p, UC paired normal collected from 12 patients investigated by quantitative real-time polymerase chain reaction. Caco-2 monolayers were used test...
Introduction Anal fissure is a common colorectal disease impacting patients' life quality with high incidence. Social media platforms are becoming kind of health information source nowadays. This study aims to evaluate and compare the anal fissure-related videos on TikTok YouTube. Materials methods One hundred were sourced from YouTube, respectively screened further. The completeness six types content within assessed, including definition disease, symptoms, risk factors, evaluation,...
Abstract The accumulation of lactate is a rising risk factor for patients after flap transplantation. Endothelial‐to‐mesenchymal transition (EndoMT) plays critical role in skin fibrosis. Nevertheless, whether overproduction directly contributes to necrosis and its mechanism remain unknown. current study reveals that mice exhibit enhanced PKM2 fibrotic response. Endothelial‐specific deletion attenuates ameliorates fibrosis mice. Administration or overexpressing promotes dysfunction...
Abstract Background The role of hydrogen sulfide (H 2 S) in cancer biology is controversial, including colorectal cancer. bell-shaped effect H S refers to pro-cancer action at lower doses and anti-cancer higher concentrations. We hypothesized that overexpression cystathionine-beta-synthase (CBS)/H exerts an inhibitory on colon cell proliferation metastasis. Methods Cell was assessed by Counting Kit-8 (CCK-8), clone-formation sphere formation assay. migration evaluated transwell Intracellular...
Long non‑coding RNA (Lnc)TCF7 is a novel lncRNA that involved in tumorigenesis. Previous studies have revealed lncTCF7 serves an essential role maintaining cancer stem cell self‑renewal; however, the functions of colorectal (CRC) remain unknown. Therefore, present study aimed to investigate CRC. LncTCF7 was upregulated 52/58 CRC tissues, and its expression correlated with tumor size, lymph metastasis tumor‑node‑metastasis stage Knocking down colon lines decreased proliferation, migration...
Lung cancer is one of the most common malignancy worldwide and causes estimated 1.6 million deaths each year. Cancer immunosurveillance has been found to play an important role in lung may be related with its prognosis. KLRK1, encoding NKG2D, a homodimeric lectin-like receptor. However, there not research KLRK1 as biomarker cancer. Data including patients` clinical characteristics RNAseq information from TCGA were downloaded. A total 1019 patients included this study, among which 407 female...
This study aimed to evaluate the efficiency of several parameters, including neutrophil-to-lymphocyte ratio (NLR) obtained from preoperative routine blood examination, either alone or as an adjunct carbohydrate antigen 19-9 (CA19-9), for diagnosis gallbladder carcinoma (GBC).Data 123 patients with cholesterol polyps (GCP), 80 adenoma (GA), and 103 GBC were reviewed retrospectively. Receiver operating characteristic analysis was used assess sensitivity, specificity, clinical value NLR,...
Objective The mitotic count of gastrointestinal stromal tumors (GIST) is closely associated with the risk planting and metastasis. purpose this study was to develop a predictive model for index local primary GIST, based on deep learning algorithm. Materials methods Abdominal contrast-enhanced CT images 148 pathologically confirmed GIST cases were retrospectively collected development classification areas masses labelled by an experienced radiologist. postoperative pathological considered as...
As a parameter integrating platelet (P), neutrophil (N), and lymphocyte (L) levels, the systemic immune-inflammation index (SII) has been used as prognostic marker for patient survival in various types of solid malignant tumors. However, there is no in-depth study non-small-cell lung cancer (NSCLC) patients with brain metastases after stereotactic radiotherapy. Therefore, we performed retrospective analysis to determine clinical value SII NSCLC who underwent radiotherapy.We enrolled 124...
Schwannomas are usually benign tumors typically found in the head, neck, and extremities, with approximately 3% originating retroperitoneum. In this case, a young male presented incidental masses left kidney Abdominal pelvic enhanced computerized tomography (CT) revealed tumor apparently from kidney, along retroperitoneal mass suspected to be metastatic lymph node. Subsequently, radical nephrectomy of resection was performed. Pathological examination confirmed as renal clear cell carcinoma...
Substantial studies have demonstrated that an elevated concentration of deoxycholic acid (DCA) in the colonic lumen may play a critical role pathogenesis intestinal barrier dysfunction and inflammatory bowel disease (IBD). The purpose this study was to investigate protective effects GYY4137, as novel synthetic H2S donor, on injury induced by sodium deoxycholate (SDC) both vivo vitro.In study, Caco-2 monolayers mouse models with high SDC were used effect GYY4137 its underlying mechanisms.In...
Extramammary Paget's disease (EMPD) is a rare malignant cutaneous tumour that commonly located in anogenital regions. The diagnosis of the always delayed, and treatment usually troublesome. This study aims to summarise clinicopathological characteristics risk factors prognosis for EMPD regions, potentially providing evidence EMPD.688 patients were sourced from Surveillance, Epidemiology End Results (SEER) program between 1992 2021. In total, 176 participants our centre 2011 2021 included...
This research aims at evaluating the quality of anal cancer and its precancerous lesions-related videos on YouTube. Cross-sectional survey design. USA. The top 150 YouTube were selected for analysis based three search terms. duplicate, irrelevant, commercial, operation-related audio-free excluded. Finally, 105 relevant included. We assessed completeness video content from six dimensions marked men having sex with (MSM)-related videos. To measure quality, DISCERN, Journal American Medical...
Purpose: We investigated which obesity-associated parameters can better predict the risk of anastomotic leakage (AL) in rectal cancer patients that underwent anterior resection rectum.Method: Patients (n = 589) who rectum with a primary anastomosis were included this study, including 44 AL and 545 without AL. Univariate analysis was used to compare demographic characteristics select factors one-to-one propensity score matching (PSM). Obesity-associated parameters, preoperative body mass...
The aim of this study was to patients diagnosed with ovary metastasis from colorectal carcinoma (OM-CRC) regarding their clinical manifestations, pathological characteristics and developments based on the results computed tomography (CT).Research conducted OM-CRC admissions our facility during period January, 2000 2020, examinations both imaging statistics.A group 21 female participants a median age 54-year-old, ranging 48 68 years old, were investigated. In univariate analyses, synchronous...
The purpose of this paper is to present the clinicopathological features primary retroperitoneal mucinous neoplasms (PRMNs), evaluate diagnostic role pre-operative radiological examinations, and determine feasibility total resection using laparoscopic approach.We retrospectively analysed 10 PRMN cases who underwent surgical from January 2000 December 2019.Ten were evaluated in study, including 1 malignant case, 4 borderline cases, 5 benign cases. most common complaints pain (60%) palpable...