A5012726295- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Infant Nutrition and Health
- RNA modifications and cancer
- Sodium Intake and Health
- Sirtuins and Resveratrol in Medicine
- Animal health and immunology
- Dietary Effects on Health
- Circular RNAs in diseases
- Antimicrobial Peptides and Activities
- Mindfulness and Compassion Interventions
- PARP inhibition in cancer therapy
Xi'an Jiaotong University
2025
Fujian Medical University
2025
Second Affiliated Hospital of Jilin University
2025
Huazhong University of Science and Technology
2025
Union Hospital
2025
Nanfang Hospital
2020-2024
Southern Medical University
2018-2024
State Key Laboratory of Oral Diseases
2020-2024
Nanchang University
2017-2024
Dalian University
2024
Abstract N6‐methyladenosine (m 6 A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role oral mucosal immunity remains ambiguous. Periodontitis a special but prevalent infectious disease characterized as hyperinflammation of mucosa bone resorption. Here, it reported that genetic deletion Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability TNFAIP3 (also known A20)...
Helicobacter pylori (H. pylori) infection is the main risk for gastric cancer (GC). However, cellular heterogeneity and underlying molecular mechanisms in H. pylori-driven tumorigenesis are poorly understood.
As the most common and lethal cancer of female gonads, ovarian (OC) has a grave impact on people's health. OC is asymptomatic, insidious in onset, difficult to diagnose treat, fast-growing, easy metastasize poor prognosis high mortality. How detect as early possible treat it without side effects become challenging medical problem. Herein, ultrasmall Au-GRHa nanosystem was designed for dual-mode imaging-guided photothermal therapy OC. The synthesized size, good biocompatibility, excellent...
Accumulating evidence indicates that high-fat diet (HFD)-induced metabolic disorders are associated with dysbiosis of the gut microbiota. However, sex-specific characteristics microbiota and its association a sexually dimorphic response to HFD remain unclear.Male female mice were randomly assigned receive chow (CD) or for 12 weeks. A group pretreated antibiotic cocktails 4 Body weight, insulin sensitivity levels serum parameters (blood glucose insulin) evaluated. 16S rRNA gene sequencing was...
Research has shown that nano-copper (nano-Cu) can cause damage to the spleen and immune system yet their mechanisms of cytotoxicity are poorly understood. Our aim is explore potential immunotoxicity in rats after nano-Cu exposure. The results hematologic parameters, lymphocyte subsets, immunoglobulins, histopathology indicated copper obviously changed function spleen. levels antioxidants (SOD, CAT, GSH-Px), oxidants (iNOS, NO, MDA), anti-oxidative signalling pathway Nrf2 (Nrf2 HO-1) were...
Let-7 family microRNAs have been reported to be downregulated in human hepatocellular carcinoma comparison with normal hepatic tissues. Among them, let-7g was identified as the lowest expression using real-time RT-PCR. However, mechanism by which works remains unknown. Here, our present study, we had reexpressed vitro cell lines MHCC97-H and HCCLM3 via transfection. The proliferation after reexpression of assayed MTT method; migration invasion restoration were detected wound-healing...
Hypoxia inducible factor-1α (HIF-1α), induces cytokines such as CXCL8 and tumor dissemination, chemo- radio-resistance. We analyzed correlation between HIF-1α levels, characteristics overall survival in 102 hepatocellular carcinoma (HCC) patients. Levels of were increased HCC tissues cell lines. Patients with high levels had worse outcome poorer prognosis than those lower levels. Co-overexpression was an independent negative prognostic factor for disease-free survival. silencing siRNA...
Porcine beta-defensin 2 (PBD-2) which is a member of the family antimicrobial peptides, widely expressed in pig organs with broad spectrum bactericidal activities confirmed vitro. We previously demonstrated that transgenic (TG) pigs overexpressing PBD-2 could resist infection by porcine pathogen Actinobacillus pleuropneumoniae. In this study, roles protecting against bacterial were further investigated. The biochemical indexes blood sample, body weights, histological morphologies and weights...
Abstract Acute pancreatitis (AP) is a common digestive disease characterized by inflammation of the pancreas. MiR-155 plays role in promoting and inhibiting activation anti-inflammatory pathways. Impaired autophagy could promote zymogen activation, abnormal acinar cell secretion, death, inflammatory response to aggravate AP. The aim this study was ascertain effect silencing miR-155 on AP through its effects impaired vivo. In study, AAV(adeno-associated virus)-mediated sponge were injected...
Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as marker outcome. Early prediction is essential for reducing mortality AP. The present study aims to assess the relationship between elevated serum D-dimer levels and severity We performed an observational retrospective data from 3451 enrolled patients Serum were measured upon admission, after 24 h during week admission by...
Abstract Background Diagnosis and treatment of prostate cancer is associated with anxiety, fear, depression in up to one-third men. Yoga improves health-related quality life (QoL) patients several types cancer, but evidence its efficacy enhancing QoL lacking cancer. Methods In this randomized controlled study, 29 men newly diagnosed localized were yoga for 6 weeks ( n = 14) or standard-of-care 15) before radical prostatectomy. The primary outcome was self-reported QoL, assessed by the...
Brown adipose tissue (BAT) is the main site of nonshivering thermogenesis which plays an important role in and energy metabolism. However, regulatory factors that inhibit BAT activity remain largely unknown. Here, cardiotrophin-like cytokine factor 1 (CLCF1) identified as a negative regulator BAT. Adenovirus-mediated overexpression CLCF1 greatly impairs thermogenic capacity reduces metabolic rate. Consistently, BAT-specific ablation enhances function expenditure under both thermoneutral cold...
Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Alternate day fasting (ADF) has gained growing attention due its metabolic benefits. However, effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in animal models. The present study was designed investigate atherosclerosis apolipoprotein E-deficient (Apoe -/- ) mice. Eleven-week-old male Apoe mice fed with Western diet (WD) were randomly grouped into ad libitum (AL) group...
Helicobacter pylori (H. pylori) infection is associated with the development of gastric cancer, although mechanism unclear. Herein, this study aimed to clarify key genes and signaling pathways involved in H. pathogenesis based on The Cancer Genome Atlas (TCGA) database RNA sequencing analysis.Forty-nine cancer samples (16 33 without 35 cancer-adjacent normal from TCGA were analyzed by bioinformatics. differentially expressed between pylori-positive pylori-negative patients verified 18 (GC)...
Organ failure (OF) and death are considered the most significant adverse outcomes in necrotizing pancreatitis (NP). However, there few NP-related studies describing clinical traits of OF aggravated outcomes.An improved insight into details will be helpful to management NP. Thus, our research, we addressed risk factors NP patients.We performed a study 432 patients from May 2017 December 2021. All with were followed up for 36 months. The primary end-points patients. evaluated by logistic...
Hypertriglyceridemia severity is linked to acute pancreatitis prognosis, but it remains unknown why a portion of severe hypertriglyceridemia patients do not develop pancreatitis. To investigate whether subtypes affect progression, we analyzed two genetically modified mouse models-namely, glycosylphosphatidylinositol high-density lipoprotein binding protein 1 knockout (Gpihbp1-/-) and apolipoprotein C3 transgenic (ApoC3-tg) mice. Acute was induced by 10 intraperitoneal caerulein injections....
Adiposity and adipokines are associated with metabolic disorders, but little is known regarding that whether adiposity measurements link syndrome (MetS) through circulating neuregulin 4 (Nrg4) adipsin levels.A total of 1212 subjects a waist circumference greater than 90 cm for men or 80 women were enrolled from Chinese community. Circulating Nrg4 levels measured using commercial kits. Mediation analyses performed in the study linear logistic regression.Subjects MetS had higher circumference,...
Integrin beta5 (ITGB5) expression levels are dysregulated in a variety of cancers. However, the mechanism and clinical value ITGB5 colorectal cancer (CRC) remain unclear. The Gene Expression Omnibus (GEO) database, real-time PCR, Western blotting immunohistochemistry were utilized to evaluate CRC tissue. Clinical data from GEO database obtained further explore associations with features patient survival. Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analysis gene...
During past decades, the construction of morphotropic phase boundary (MPB) behavior in ceramic-based relaxor ferroelectrics has successfully led to a significant enhancement piezoelectric coefficient for actuators, transducers, and sensors application. However, MPB-like is achieved only ferroelectric state flexible polymers such as poly(vinylidene fluoride-trifluoroethylene) with highest coefficients ≈-63.5 pC/N, due lack rational design polymer chain structure composition. Here, study...
Smooth Brucella are the main pathogenic bacteria that threaten human health and food safety. The early stage of smooth macrophage interaction is an important phase, species elicit a dramatic transcriptional response in infected macrophages. However, key events still obscure. This study aimed to identify candidate pathways genes macrophages with at stage. Three gene expression profiles including GSE21117, GSE5202, GSE8385 were retrieved from NCBI GEO database, integrated using comprehensive...