A5053129917- Diversity and Career in Medicine
- Innovations in Medical Education
- Breast Cancer Treatment Studies
- Global Health Workforce Issues
- Sex and Gender in Healthcare
- Acute Myocardial Infarction Research
- Genetic factors in colorectal cancer
- Dermatologic Treatments and Research
- Migration, Health and Trauma
- Cancer Genomics and Diagnostics
- Mental Health Treatment and Access
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Atrial Fibrillation Management and Outcomes
- Reproductive Biology and Fertility
- Healthcare cost, quality, practices
- Health Systems, Economic Evaluations, Quality of Life
- Empathy and Medical Education
- Cancer Research and Treatments
- Global Health and Surgery
- Schizophrenia research and treatment
Shanghai University of Medicine and Health Sciences
2017-2024
University Hospital of Basel
2014-2023
Renji Hospital
2021-2023
Shanghai Jiao Tong University
2020-2023
University of Naples Federico II
2020-2022
University of Basel
2017-2021
Women's Brain Project
2019-2021
Shanghai Medical College of Fudan University
2021
Fudan University Shanghai Cancer Center
2021
Maastricht University
2020-2021
Alzheimer’s disease (AD) is characterized by high heterogeneity in manifestation, progression and risk factors. High phenotypic variability currently regarded as one of the largest hurdles early diagnosis design clinical trials; there therefore great interest identifying factors driving that can be used for patient stratification. In addition to genetic lifestyle factors, individual’s sex gender are emerging crucial drivers variability. Evidence exists on differences rate cognitive...
Abstract Although the importance of research mentorship has been well established, role mentors junior clinical and translational science investigators is not clearly defined. The authors attempt to derive a list actionable competencies for from series complementary methods. We examined focus groups, literature, derived scholars, mentor training curricula, evaluation forms finally conducted an expert panel process in order compose this list. These efforts resulted set that include generic...
Hypoxia inducible factor-1α (HIF-1α), induces cytokines such as CXCL8 and tumor dissemination, chemo- radio-resistance. We analyzed correlation between HIF-1α levels, characteristics overall survival in 102 hepatocellular carcinoma (HCC) patients. Levels of were increased HCC tissues cell lines. Patients with high levels had worse outcome poorer prognosis than those lower levels. Co-overexpression was an independent negative prognostic factor for disease-free survival. silencing siRNA...
Cellular adaptive mechanisms are crucial for tumorigenesis and a common feature in solid tumor progression. Hypoxia-inducible factor-1α (HIF-1α) facilitates the biological response to hypoxia, advancing angiogenesis metastatic potential of tumor. The peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α) enhances mitochondrial biogenesis, favored by migratory/invasive cancer cells. We conducted prospective, long-term follow up study determine whether HIF-1α PGC-1α can be...
Background: Although psychoactive substance use disorders (PSUDs) are a domain of mental health, addiction psychiatry is only formally recognized as subspecialty in few European countries, and there no standardized training curriculum. Methods: A 76-item questionnaire was developed disseminated through an online anonymous data-collecting system hand-to-hand amongst psychiatric trainees from the 47 countries Council Europe plus Israel Belarus. Results: 1,049/1,118 30 completed questionnaire....
Abstract Background The Clinical Frailty Scale (CFS) is frequently used to measure frailty in critically ill adults. There wide variation the approach analysing relationship between CFS score and mortality after admission ICU. This study aimed evaluate influence of modelling on association short-term quantify prognostic value this context. Methods We analysed data from two multicentre prospective cohort studies which enrolled intensive care unit patients ≥ 80 years old 26 countries. primary...
There is a shortage of psychiatrists worldwide. Within Europe, psychiatric trainees can move between countries, which increases the problem in some countries and alleviates it others. However, little known about reasons to another country.Survey 33 European exploring how frequently have migrated or want migrate, their stay leave country, where they come from to. A 61-item self-report questionnaire was developed, covering questions demographics, experiences short-term mobility (from 3 months...
The novel E3 ubiquitin-protein ligase neural precursor cell-expressed developmentally downregulated protein 4 (NEDD4) has been implicated as a crucial factor promoting the tumorigenesis of several types cancer. present study investigated oncogenic role NEDD4 in hepatocellular carcinoma (HCC) by targeted small interfering RNA silencing tumor suppressor phosphatase and tensin homolog (PTEN). Using normal hepatocyte HCC cell lines, influence depletion on proliferation migration well...
The effectiveness of intensive care unit (ICU) for cancer patients remains controversial. Advances in antitumour and supportive led to major improvements outcomes oncological the ICU. Improved therapies management organ dysfunctions have contributed improved survival rates. As a consequence, number requiring ICU admission is rising. Frequently, poor performance status are vulnerable. It heterogeneous population, where nature curability neoplasm severity critical illness cause plethora issues...
Background and Objects: Malignant phyllodes tumor of the breast (MPTB) is a rare for which surgery or combined with radiotherapy (RT) primary treatment method. However, recently, therapeutic effect RT on MPTB has been controversial. We aimed to explore role RT, chemotherapy (CT), surgical modalities in patients MPTB. Methods: The Surveillance, Epidemiology, End Results (SEER) database was used select who met criteria between 2010 2018. Kaplan–Meier curves Cox proportional risk regression...
Approximately one in four myocardial infarctions occur older patients. The majority of therapeutic advances are either not appropriate or tested elderly main reasons for deviating from the guidelines justified concerns regarding effectiveness recommended forms therapy, fear adverse drug reactions and ethical concerns. Targeting interleukin 6 (IL‑6) ventricular remodeling after cardiovascular damage is a feasible alternative to standard polypharmaceutics, but underlying molecular mechanisms...
Extracellular vesicles (EVs) show potential as a therapeutic tool for peripheral nerve injury (PNI), promoting neurological regeneration. However, there are limited data on the in vivo spatio-temporal trafficking and biodistribution of EVs. In this study, we introduce new non-invasive near-infrared fluorescence imaging strategy based glucose-conjugated quantum dot (QDs-Glu) labeling to target track EVs sciatic rat model real-time. Our results demonstrate that injected migrated from uninjured...
Hepatic inflammatory pseudotumors (HIPT) are rare benign neoplasms with unknown etiology and a great potential for mimicry, challenging diagnostics, treatment features. The aim of the study was to retrospectively analyze imaging, pathological, clinical features HIPT in our large cohort patients order increase understanding suggest scoring system approaches. Retrospective analyzed 114 cases recorded from July 2006 2012, when surgery performed. Data were compared chi-square test. In...
To date, no studies compared curative effects of thermal lesions in deep and superficial dermal layers the same patient (face-split study).To evaluate skin laxity microneedle fractional radiofrequency induced different layers.13 patients underwent three sessions a randomized face-split system (MFRS) treatment layer. Skin changes were evaluated objectively (digital images, 2 independent experts) subjectively (patients' satisfaction numerical rating).12 13 subjects completed course 3...
Bone targeted therapies are of increasing importance, not only for bone health in the clinical course breast cancer, but recently also adjuvant setting as preventative, anticancer and prognosis-improving agents. It is well established that women with advanced cancer receive bisphosphonates or denosumab to prevent therapy-related osteoporosis. As many 70% these patients suffer from metastases agents order skeletal related events (SREs), which debilitating diminish quality life. A number...
Uterine fibroids are the most common type of benign, gynecologic neoplasm and primary indication for performance a hysterectomy, accounting >200,000 hysterectomies annually in USA. At present, females younger exhibit larger leiomyomas at time diagnosis. Cancer-associated fibroblasts tumor microenvironments have emerged as an important target cancer therapy. Repeated stimulation by infectious or non-infectious agents uterine tissues, including inflammation, mechanical forces hypoxia,...
Protein ubiquitinylation regulates protein stability and activity. RAD6, an E2 ubiquitin-conjugating enzyme, which that has been substantially biochemically characterized, functions in a number of biologically relevant pathways, including cell cycle progression. In this study, we show RAD6 promotes the G1-S transition proliferation by regulating expression cyclin D1 (CCND1) human cells. Furthermore, our data indicate influences transcription CCND1 increasing monoubiquitinylation histone H2B...