Mario Meier
A5018392358- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Healthcare cost, quality, practices
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Antimicrobial Resistance in Staphylococcus
- Hepatitis C virus research
- Emergency and Acute Care Studies
- Cardiovascular Function and Risk Factors
- Hepatitis B Virus Studies
- Cardiac electrophysiology and arrhythmias
- Hemodynamic Monitoring and Therapy
- Immunotherapy and Immune Responses
- Cardiac, Anesthesia and Surgical Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Non-Invasive Vital Sign Monitoring
- ECG Monitoring and Analysis
University Hospital of Basel
2017-2025
University of Basel
2017-2023
Until now, high-sensitivity cardiac troponin (hs-cTn) assays were mainly developed for large central laboratory platforms. This study aimed to assess the clinical performance of a point-of-care (POC)-hs-cTnI assay in patients with suspected myocardial infarction (MI). enrolled presenting emergency department symptoms suggestive MI. Two cardiologists centrally adjudicated final diagnosis using all data including imaging. The primary objective was directly compare diagnostic accuracy...
The aim of this study was to validate the clinical performance Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.We enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists all information including imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, hs-cTnI (Architect, secondary analysis) measurements in addition...
Abstract BACKGROUND We aimed to validate the clinical performance of high-sensitivity cardiac troponin I [VITROS® Immunodiagnostic Products hs Troponin (hs-cTnI-VITROS)] assay. METHODS enrolled patients presenting emergency department with symptoms suggestive acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists considering all information, including imaging: first, using serial hs-cTnT-Elecsys (primary analysis) and, second,...
Background: The non–ST-segment–elevation myocardial infarction (NSTEMI) guidelines of the European Society Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to observe-zone ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, 0/3h high-sensitivity T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation. Methods: Patients presenting with acute chest discomfort emergency department were prospectively...
Abstract BACKGROUND We aimed to derive and externally validate a 0/2-h algorithm using the high-sensitivity cardiac troponin I (hs-cTnI)-Access assay. METHODS enrolled patients presenting emergency department with symptoms suggestive of acute myocardial infarction (AMI) in 2 prospective diagnostic studies central adjudication. Two independent cardiologists adjudicated final diagnosis, including all available medical information imaging. hs-cTnI-Access concentrations were measured at...
Background/Objectives: Atrial fibrillation (AF) remains a major risk factor for stroke. It is often asymptomatic and paroxysmal, making it difficult to detect with conventional electrocardiography (ECG). While photoplethysmography (PPG)-based devices like smartwatches have demonstrated efficacy in detecting AF, they are rarely integrated into hospital infrastructure. The study aimed establish seamless system real-time AF screening hospitalized high-risk patients using wrist-worn PPG device...
The utility of clinical risk scores regarding the prediction major adverse cardiac events (MACE) is uncertain. We aimed to directly compare prognostic performance five established as well an unstructured integrated judgement (ICJ) treating emergency department (ED) physician.Thirty-day MACE including all-cause death, life-threatening arrhythmia, cardiogenic shock, acute myocardial infarction (including index event), and unstable angina requiring urgent coronary revascularization were...
Summary Current treatment options for patients with chronic hepatitis B virus ( HBV ) infection are not curative as they effective in eliminating covalently closed circular DNA (ccc ). ccc is a stable template transcription the nucleus of hepatocytes and thought to be one main factors responsible persistence. Recently, activation lymphotoxin beta receptor LT βR) has been shown trigger degradation through induction cytidine deaminases APOBEC 3 family cell culture model systems. To assess...
Abstract Aims After rule-out of non-ST elevation myocardial infarction (NSTEMI) with the European Society Cardiology (ESC) 0/1 h-algorithms, it is unclear which patients require further anatomical or functional cardiac testing. To test safety and efficacy no-objective-testing (NOT)-rules after NSTEMI by ESC h-algorithms. Methods results International, prospective, diagnostic multicentre study enrolling adult presenting chest pain to emergency department. Central adjudication final diagnosis...
Abstract Background Clinical risk scores are recommended for formal stratification in patients presenting with suspected acute coronary syndrome (ACS). It is unknown, whether these still provide additional value the era of high-sensitivity cardiac troponin (hs-cTn) compared to simple integrated clinical judgment. Purpose To evaluate diagnostic and prognostic performance judgment scores. Methods We prospectively enrolled emergency department symptoms suggestive ACS such as chest discomfort....
Abstract Background Atrial Fibrillation (AF) is the leading cause of stroke, and its prevalence expected to rise. While early detection crucial in preventing thromboembolic events, often asymptomatic paroxysmal nature makes it challenging capture using conventional electrocardiography (ECG). Photoplethysmography (PPG) enabled devices, such as smartwatches, allow continuous monitoring heart rhythm accurate screening for AF. Purpose In this study, we aimed build an IT-infrastructure fully...
Abstract Background The ESC recommends the use of a 0/1h-algorithm for rapid triage patients with suspected non-ST-elevation myocardial infarction (NSTEMI) using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective renal function. Patients dysfunction (RD, defined as GFR <60ml/min) are at higher risk NSTEMI and presenting more often elevated levels hs-cTn even in absence NSTEMI, which may contribute to an impaired efficacy safety 0/1h-algorithm. Purpose We aimed assess...
Abstract Background The clinical utility of risk scores in patients presenting with suspected acute coronary syndromes to the emergency department (ED) is uncertain. Purpose We aimed directly compare performance three established simple integrated judgment (ICJ) treating ED physician. Methods Thirty day major adverse cardiac events (MACE) including all-cause death, life-threatening arrhythmia, cardiogenic shock, myocardial infarction (AMI, index event), and unstable angina requiring urgent...