A5002638875- Alzheimer's disease research and treatments
- Sex and Gender in Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- Science, Research, and Medicine
- Diversity and Career in Medicine
- Stress Responses and Cortisol
- COVID-19 epidemiological studies
- Hormonal Regulation and Hypertension
- Autism Spectrum Disorder Research
- Mental Health and Patient Involvement
- Genetics, Aging, and Longevity in Model Organisms
- Ethics in Clinical Research
- Neurogenesis and neuroplasticity mechanisms
- COVID-19 and healthcare impacts
- 14-3-3 protein interactions
- Genetic Associations and Epidemiology
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Nuclear Receptors and Signaling
Karolinska Institutet
2024-2025
Women's Brain Project
2018-2024
University of Toronto
2024
Health Net
2024
University Health Network
2024
Günter-Köhler-Institut für Fügetechnik und Werkstoffprüfung
2024
University of Zurich
2012-2023
Swiss Institute for Regenerative Medicine
2016-2023
Shanghai East Hospital
2020
Shanghai University of Medicine and Health Sciences
2020
Abstract Introduction Global estimates on numbers of persons in early stages Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet needed to inform policy decisions preventive measures planning for future therapies targeting AD pathology. Methods We synthesized the literature prevalence across continuum derived a model estimating number persons, stratified by 5‐year age groups, sex, stage (AD dementia, AD, preclinical AD). Results The global with were estimated at...
Alzheimer's disease (AD) is a neurodegenerative pathology in which amyloid-β (Aβ) peptide accumulates different brain areas leading to deposition of plaques and progressive decline cognitive functions. After decade number tran
<b><i>Background:</i></b> Strong genetic and epidemiological evidence points to a crucial role of the immune system in development Alzheimer disease (AD). CD3+ T lymphocytes have been described brains postmortem AD patients transgenic models AD-like cerebral amyloidosis tau pathology. However, occurrence cells is still controversial; furthermore, relationship between hallmarks pathology (amyloid plaques neurofibrillary tangles) remains be established....
Cerebral beta-amyloidosis, one of the pathological hallmarks Alzheimer's disease (AD), elicits a well-characterised, microglia-mediated local innate immune response. In contrast, it is not clear whether cells adaptive system, in particular T-cells, react to cerebral amyloidosis AD. Even though parenchymal T-cells have been described post-mortem brains AD patients, known infiltrating are specifically recruited extracellular deposits beta-amyloid, and they locally activated into proliferating,...
Alzheimer’s disease (AD) is characterized by high heterogeneity in manifestation, progression and risk factors. High phenotypic variability currently regarded as one of the largest hurdles early diagnosis design clinical trials; there therefore great interest identifying factors driving that can be used for patient stratification. In addition to genetic lifestyle factors, individual’s sex gender are emerging crucial drivers variability. Evidence exists on differences rate cognitive...
Abstract Background A growing body of evidence indicates that inflammation is one the earliest neuropathological events in Alzheimer's disease. Accordingly, we have recently shown occurrence an early, pro-inflammatory reaction hippocampus young, three-month-old transgenic McGill-Thy1-APP mice absence amyloid plaques but associated with intracellular accumulation beta petide oligomers. The role such a process progression pathology remained to be elucidated. Methods and results To clarify this...
The occurrence of a plaque-dependent inflammation in Alzheimers disease has been extensively documented both human specimens and transgenic models the disease. Since insoluble plaques are present AD patients from early preclinical stages pathology, point at which neuroinflammation first occurs progression pathology is still unknown. In this review we discuss clinical experimental evidence for preclinical, asymptomatic phases pathology. particular, different suggesting that pro-inflammatory...
In Alzheimer’s disease, accumulation and pathological aggregation of amyloid β-peptide is accompanied by the induction complex immune responses, which have been attributed both beneficial detrimental properties. Such responses implicate various cell types innate adaptive arm immunesystem, inside central nervous system, in periphery. To investigate role system brain β-amyloidosis, PSAPP transgenic mice, an established mouse model were crossbred with recombination activating gene-2 knockout...
Fast and minimally invasive approaches for early diagnosis of Alzheimer's disease (AD) are highly anticipated. Evidence adaptive immune cells responding to cerebral β-amyloidosis has raised the question whether markers could be used as proxies β-amyloid accumulation in brain.
Abstract Traumatic brain injury (TBI) is the leading cause of disability in working population and becomes increasingly prevalent elderly. Thus, TBI a major global health burden. However, age- sex-related long-term outcome regarding patient’s health-related quality life (HRQoL) yet not clarified. In this cross-sectional study, we present demographics HRQoL up to 10 years after using Quality Life Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero 100 indicating good...
Abstract Targeted contact-tracing through mobile phone apps has been proposed as an instrument to help contain the spread of COVID-19 and manage lifting nation-wide lock-downs currently in place USA Europe. However, there is ongoing debate on its potential efficacy, especially light region-specific demographics. We built expanded S I R model epidemics that accounts for population densities, we used it test impact a app number scenarios. Using demographic mobility data from Italy Spain,...
Objectives To investigate public perspectives on brain health. Design Cross-sectional multilanguage online survey. Setting Lifebrain posted the survey its website and social media shared it with stakeholders. The was open from 4 June 2019 to 31 August 2020. Participants n=27 590 aged ≥18 years 81 countries in five continents completed respondents were predominantly women (71%), middle (41–60 years; 37%) or above (>60 46%), highly educated (69%) resided Europe (98%). Main outcome measures...
Introduction Choroid plexus (CP)-related mechanisms have been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease. In this pilot study, we aimed to elucidate association between longitudinal changes CP volume, sex and cognitive impairment. Methods We assessed volume a cohort n = 613 subjects across 2,334 datapoints from ADNI 2 ADNI-GO, belonging cognitively unimpaired (CN), stable mild impairment (MCI), clinically diagnosed disease dementia (AD) or...