A5061687105- Vestibular and auditory disorders
- Balance, Gait, and Falls Prevention
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Cerebral Palsy and Movement Disorders
- Glaucoma and retinal disorders
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Genetic Neurodegenerative Diseases
- Migraine and Headache Studies
- Visual perception and processing mechanisms
- Neurological disorders and treatments
- Neuroscience of respiration and sleep
- Parkinson's Disease Mechanisms and Treatments
- Motor Control and Adaptation
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Tactile and Sensory Interactions
- Spatial Cognition and Navigation
- Cerebral Venous Sinus Thrombosis
- Memory and Neural Mechanisms
- Action Observation and Synchronization
- Muscle activation and electromyography studies
Ludwig-Maximilians-Universität München
2016-2025
German Center for Lung Research
2016-2025
Schön Klinik Bad Aibling
2016-2025
Friedrich Baur Stiftung
2022
München Klinik
1999-2020
Institute for Neurodegenerative Disorders
2020
Imperial College London
2020
Munich Cluster for Systems Neurology
2018-2020
Brandenburg University of Technology Cottbus-Senftenberg
2020
LMU Klinikum
2006-2018
Vestibular neuritis is the second most common cause of peripheral vestibular vertigo. Its assumed a reactivation herpes simplex virus type 1 infection. Therefore, corticosteroids, antiviral agents, or combination two might improve outcome in patients with neuritis.We performed prospective, randomized, double-blind, two-by-two factorial trial which acute were randomly assigned to treatment placebo, methylprednisolone, valacyclovir, methylprednisolone plus valacyclovir. function was determined...
<h3>Background</h3> Vertigo and dizziness are often not fully explained by an organic illness, but instead related to psychiatric disorders. This study aimed evaluate comorbidity assess psychosocial impairment in a large sample of patients with wide range unselected non-organic (ie, medically unexplained) vertigo/dizziness syndromes. <h3>Methods</h3> cross-sectional involved 547 recruited from specialised interdisciplinary treatment centre for vertigo/dizziness. Diagnostic evaluation...
This paper describes the diagnostic criteria for Acute Unilateral Vestibulopathy (AUVP), a synonym vestibular neuritis, as defined by Committee Classification of Vestibular Disorders Bárány Society. AUVP manifests an acute syndrome due to unilateral loss peripheral function without evidence central or audiological symptoms signs. implies that diagnosis is based on patient history, bedside examination, and, if necessary, laboratory evaluation. The leading symptom rarely subacute onset...
To determine the causative factors and epidemiology of bilateral vestibulopathy (BV).This is a retrospective review 255 patients (mean age, 62 +/- 16 years) with BV diagnosed in our dizziness unit between 1988 2005. All had undergone standardized neurophthalmological neurootological examination, electronystagmography caloric irrigation, cranial magnetic resonance imaging or computed tomography (n = 214), laboratory tests.Sixty-two percent study population were male subjects. Previous vertigo...
<b><i>Background:</i></b> Several drugs that primarily act on γ-aminobutyrate or muscarinic receptors have been used to treat downbeat nystagmus (DBN) syndrome despite their having only moderate success and causing several side effects limit effectiveness. These were tested under the assumption DBN was caused by a disinhibition of physiologic inhibitory cerebellar input vestibular nuclei. <b><i>Objective:</i></b> To evaluate single dose potassium channel blocker 3,4-diaminopyridine...
The therapeutic effects of 4-aminopyridine (4AP) were investigated in a randomized, double-blind, crossover trial 10 subjects with familial episodic ataxia nystagmus.After randomization, placebo or 4AP (5 mg 3 times daily) was administered for 2 3-month-long treatment periods separated by 1-month-long washout period. primary outcome measure the number attacks per month; secondary measures attack duration and patient-reported quality life (Vestibular Disorders Activities Daily Living Scale...
Abstract Temporal gait variability is a critical parameter in patients with balance problems. Increased magnitude of temporal corresponds to higher risk falls. The purpose this study was investigate the influence walking speed on stride‐to‐stride cerebellar and vestibular deficits. A GAITRite system used analyze 40 ataxia, 22 bilateral failure, 51 healthy subjects over entire range individual's capacity. coefficient stride time calculated for each walk. increased patients. depended...
Bilateral vestibulopathy (BVP) is defined as the impairment or loss of function either labyrinths eighth nerves. Patients with total BVP due to bilateral vestibular nerve section exhibit difficulties in spatial memory and navigation show a hippocampal volume. In clinical practice, most patients do not have complete but rather an asymmetrical residual functioning system. The purpose current study was investigate navigational ability atrophy function. Fifteen group age- gender- matched healthy...
BACKGROUND: Vertigo and dizziness are among the most prevalent symptoms in neurologic disorders. Although many of these patients suffer from postural instability gait disturbances, there is only limited data on their risk falling. METHODS: We conducted a controlled cross-sectional study at t he tertiary care outpatient clinic German Center for Balance Disorders using self-administered questionnaire to assess falls, fall-related injuries, fear The recruitment period was 6 months. RESULTS: A...
<h3>Objective:</h3> To determine how postural imbalance and falls are related to regional cerebral glucose metabolism (PET) functional activation of the network (fMRI) in patients with progressive supranuclear palsy (PSP). <h3>Methods:</h3> Sixteen PSP, who had self-monitored their frequency falls, underwent a standardized clinical assessment, posturographic measurement balance during modified sensory input, resting [<sup>18</sup>F]FDG-PET. In addition, performed an fMRI paradigm using...
<h3>Objective:</h3> To examine the effects of imperceptible levels white noise galvanic vestibular stimulation (nGVS) on dynamic walking stability in patients with bilateral vestibulopathy (BVP). <h3>Methods:</h3> Walking performance 13 confirmed BVP (mean age 50.1 ± 5.5 years) at slow, preferred, and fast speeds was examined during zero-amplitude nGVS (sham trial) nonzero-amplitude set to 80% individual cutaneous threshold for GVS (nGVS trial). Eight standard gait measures were analyzed:...
Background: Complaints of vertigo and dizziness are common in primary care the aged. They can be caused by distinct vestibular disorders, but also a symptom other conditions like non-vestibular sensory loss, vascular encephalopathy or anxiety. The aim this study was to investigate specific contribution total burden disability aged persons when controlling for presence health conditions. Methods: Data originate from MONICA/KORA study, population-based cohort. Survivors original cohorts who...
This paper describes the diagnostic criteria for "Vestibular Migraine of Childhood", "probable Vestibular Childhood" and "Recurrent Vertigo as put forth by Committee Classification Disorders Bárány Society (ICVD) subgroup International Headache Society. plays an important role in some subgroups children with recurrent vertigo. In this classification a spectrum three disorders is described which migraine component varies from definite to possibly absent. These are: Childhood, probable...
This paper presents diagnostic criteria for vascular vertigo and dizziness as formulated by the Committee Classification of Vestibular Disorders Bárány Society. The classification includes vertigo/dizziness due to stroke or transient ischemic attack well isolated labyrinthine infarction/hemorrhage, vertebral artery compression syndrome. Vertigo are among most common symptoms posterior circulation strokes. Vascular may be acute prolonged (≥24 hours) (minutes < 24 hours). should considered...