A5033125462- Alzheimer's disease research and treatments
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Cholinesterase and Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Monoclonal and Polyclonal Antibodies Research
- Axon Guidance and Neuronal Signaling
- Dementia and Cognitive Impairment Research
- Pharmacological Receptor Mechanisms and Effects
- Sleep and Wakefulness Research
- Electroconvulsive Therapy Studies
- Neurotransmitter Receptor Influence on Behavior
- Computational Drug Discovery Methods
- Pharmacological Effects and Toxicity Studies
- Nuclear Receptors and Signaling
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Glycosylation and Glycoproteins Research
McGill University
2016-2025
University of Oxford
1984-2025
Inserm
2019-2022
Centre National de la Recherche Scientifique
2019-2022
Laboratoire d’Imagerie Biomédicale
2022
Alzheimer Precision Medicine
2019-2022
Alzheimer’s Disease Neuroimaging Initiative
2022
Université de Montréal
2019
Assistance Publique – Hôpitaux de Paris
2019
Pitié-Salpêtrière Hospital
2019
Abstract A detailed account of the distribution immunoreactive substance P‐containing structures in rat central nervous system is presented, from results obtained by applying an indirect immunofluorescent technique. High densities nerve terminals were present sensory nuclei and other non‐sensory such as thalamus, hypothalamus extrapyramidal system. Substance P‐reactive neuron cell bodies spinal root ganglia, nucleus habenulae medialis, interpeduncularis, caudoputamen globus pallidus. Most...
Peptides with transmitter-like characteristics are being found in many brain areas. The application of immunocytochemical and radioimmunoassay methods has contributed much to the clarification these neuronal systems. Here we report development a rat monoclonal antibody produced by hybrid myeloma its study one peptides, substance P. clone, isolated after fusion mouse cells hyperimmune spleen cells, allowed us obtain standardized permanent source P antibodies culture cell system. This...
The coexistence of galanin (GAL)-like immunoreactivity (LI) with markers for catecholamines, 5-hydroxytryptamine (5-HT), GABA, or some neuropeptides was mapped in the rat CNS by using adjacent sections, as well elution-restaining and double-labeling immunocytochemistry. Many instances were observed, but there also numerous GAL-positive cell body populations displaying distributions similar to those these without apparent coexistence. In hypothalamic arcuate nucleus GAL-LI found a large...
Abstract— High concentrations of dopamine were found in the nucleus accumbens and olfactory tubercle rat brain using a radiochemical enzymatic assay technique. An active uptake system for [ 3 H]dopamine that is temperature sensitive dependent on external sodium ions present synaptosome‐rich homogenates these two areas. This process potently inhibited by benztropine (IC 50 = 2.0 × 10 ‐7 m ). Dextroamphetamine d was 4.5 times more potent than 1‐amphetamine inhibiting six corpus striatum . Low...
In this report, we provide direct demonstration that the neurotrophin nerve growth factor (NGF) is released in extracellular space an activity-dependent manner its precursor form (proNGF) and it compartment maturation degradation takes place because of coordinated release action proenzymes enzyme regulators. This converting protease cascade endogenous regulators (including tissue plasminogen activator, plasminogen, neuroserpin, matrix metalloproteinase 9, inhibitor 1) are colocalized neurons...
Importance National Institute on Aging–Alzheimer’s Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective To assess the clinical value of these older without cognitive impairment who are at near-term risk developing symptomatic AD. Design, Setting, and Participants This longitudinal cohort study used data from 4 independent population-based cohorts (PREVENT-AD, HABS, AIBL, Knight ADRC)...
Abstract The role of the hippocampus in spatial navigation has been primarily studied nocturnal mammals, such as rats, that lack many adaptations for daylight vision. Here we demonstrate during 3D navigation, common marmoset, a new world primate adapted to daylight, predominantly uses rapid head-gaze shifts visual exploration while remaining stationary. During active locomotion marmosets stabilize head, contrast rats use low-velocity head movements scan environment they locomote. Pyramidal...