A5059017104- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Receptor Mechanisms and Signaling
- Neurotransmitter Receptor Influence on Behavior
- Memory Processes and Influences
- Electroconvulsive Therapy Studies
- Neuroendocrine regulation and behavior
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Schizophrenia research and treatment
- Neural dynamics and brain function
- Forensic Toxicology and Drug Analysis
- Treatment of Major Depression
- Epilepsy research and treatment
- RNA regulation and disease
- Sleep and related disorders
- Anesthesia and Neurotoxicity Research
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- Coffee research and impacts
- Genetics and Neurodevelopmental Disorders
- Neuropeptides and Animal Physiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
McGill University
2015-2024
Massachusetts Institute of Technology
2024
Ruhr University Bochum
2023
The University of Texas at Austin
2020-2023
Concordia University
2023
University of California, Los Angeles
2023
American University in Cairo
2023
Delta University for Science and Technology
2019-2022
Douglas Mental Health University Institute
2014
Emory University
2011
Phosphorylation of the α-subunit initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating unique serine in eIF2α. This collection signaling pathways is termed 'integrated response' (ISR). phosphorylation diminishes synthesis, while allowing preferential translation some mRNAs. Starting with cell-based screen for inhibitors PERK signaling,...
Reactivation of consolidated memories returns them to a protein synthesis-dependent state. One interpretation these findings is that the memory reconsolidates after use. Two alternative interpretations are synthesis inhibition facilitates extinction and postreactivation leads an inability retrieve memory. First, using two different approaches, we report reconsolidation cannot be reduced down facilitated extinction. We show deficit does not renewal contextual shift, whereas extinguished...
It is well established that the amygdala plays an essential role in Pavlovian fear conditioning, with lateral nucleus serving as interface sensory systems transmit conditioned stimulus and central link motor regions control responses. The connects directly by way of several other regions, including basal, accessory medial nuclei. To determine which these necessary, thus whether conditioning requires direct or one indirect intra-amygdala pathways, we made lesions rats lateral, central,...
Abstract Consolidation of new fear memories has been shown to require de novo RNA and protein synthesis in the lateral nucleus amygdala (LA). Recently we have demonstrated that consolidated memories, when reactivated, return a labile state which is sensitive disruption by inhibitor anisomycin. The specific molecular mechanisms underlie this reconsolidation are still largely unknown. activation extracellular signal‐regulated kinase–mitogen‐activated kinase (ERK–MAPK) pathway LA required for...
Memory consolidation refers to a process by which newly learned information is made resistant disruption. Traditionally, has been viewed as an event that occurs once in the life of memory. However, considerable evidence now indicates consolidated memories, when reactivated through retrieval, become labile (susceptible disruption) again and undergo reconsolidation. Because memories are often interrelated complex associative networks rather than stored isolation, key question whether...