A5100717454- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- HER2/EGFR in Cancer Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Breast Cancer Treatment Studies
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Transcranial Magnetic Stimulation Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Microtubule and mitosis dynamics
- Protease and Inhibitor Mechanisms
- Caveolin-1 and cellular processes
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
Fujian Medical University
2009-2025
Union Hospital
2016-2025
Shanghai Public Health Clinical Center
2025
Affiliated Eye Hospital of Wenzhou Medical College
2025
Wenzhou Medical University
2025
Children's Hospital of Zhejiang University
2024
University of South China
2024
Qingdao University
2024
Affiliated Hospital of Qingdao University
2024
Shandong Provincial Hospital
2013-2023
The value of platinum-based adjuvant chemotherapy in patients with triple-negative breast cancer (TNBC) remains controversial, as does whether BRCA1 and BRCA2 (BRCA1/2) germline variants are associated platinum treatment sensitivity.To compare 6 cycles paclitaxel plus carboplatin (PCb) a standard-dose regimen 3 cyclophosphamide, epirubicin, fluorouracil followed by docetaxel (CEF-T).This phase randomized clinical trial was conducted at 9 centers hospitals China. Between July 1, 2011, April...
Abstract Albuvirtide (ABT) is a novel long‐acting fusion inhibitor for human immunodeficiency virus type 1 (HIV‐1), and may be co‐administered with rifampicin (RIF) in patients concurrent tubercle bacillus HIV‐1. This study was conducted to investigate the pharmacokinetic effect of co‐administration two drugs. In study, 24 healthy volunteers were randomized receive ABT alone or RIF. Plasma concentrations measured using liquid chromatography‐tandem mass spectrometry RIF competitive...
Abstract Background The purpose of this study is to evaluate the prognostic value TFPI-2 expression in breast cancer patients through examining correlation between and clinicopathologic features. Methods Immunohistochemical staining combined with digital image analysis was used quantify protein tumor tissues. For evaluation each factor, Kaplan-Meier method COX’s Proportional Hazard Model were employed. Results significantly correlated size, lymph node metastasis, histologic grade, clinical...
Methyltransferase-like 3 (METTL3) has been identified as a methyltransferase responsible for N6-methyla-denosine (m6A) modification of mRNA. METTL3 functions in tumorigenesis and tumor development by promoting the translation oncoproteins; however, role ovarian cancer not extensively studied. The present study performed immunohistochemistry to detect expression levels 52 samples tissue paired with corresponding paracancerous tissue. RNA interference was conducted downregulate SKOV3 OVCAR3...
Cellular adaptive mechanisms are crucial for tumorigenesis and a common feature in solid tumor progression. Hypoxia-inducible factor-1α (HIF-1α) facilitates the biological response to hypoxia, advancing angiogenesis metastatic potential of tumor. The peroxisome proliferator-activated receptor γ coactivators 1α (PGC-1α) enhances mitochondrial biogenesis, favored by migratory/invasive cancer cells. We conducted prospective, long-term follow up study determine whether HIF-1α PGC-1α can be...
Non-alcoholic fatty liver disease (NAFLD) is a chronic and progressive with an increased risk of morbidity mortality. However, so far no specific pharmacotherapy has been approved. Gynostemma pentaphylla (Thunb.) Makino (GP) traditional Chinese medicine that widely used against hyperlipemia as well hyperglycemia. This study aims to evaluate the effect GP on NAFLD explore possible mechanism. High-fat-diet induced mice model were orally administrated at dose 11.7 g/kg or equivalent volume...
Background Gastric cancer (GC) has a high morbidity and mortality rate, with peritoneal metastasis (PM) identified as the main site of metastasis. Our previous study found that FNDC1 higher frequency mutations in patients PM by high-throughput sequencing assay, suggesting it may be associated GC invasion PM, however specific mechanism remains unclear. Methods First, correlation between prognosis was clarified bioinformatics clinicopathological analysis. Next, effect expression on ability...
Deubiquitinating enzymes (DUBs) serve to maintain cellular homeostasis via protein ubiquitination and exert diverse regulatory functions in cancers other diseases. Much progress has been made characterizing biological roles of DUBs over the decades, yet specific many subclass members remain largely unexplored. It was not until recent years that role ubiquitin-specific-processing protease 35 (USP35) began be understood. Here, we focus on delineating underlying mechanisms USP35 non-small cell...
ABSTRACT Osteopetrosis (OMIM: 611497), literally “stone bone,” is a group of inherited bone disorders characterized by increased skeletal mass due to defective osteoclast function. A patient who reported history frequent fractures, weakness and fatigue was admitted our hospital in 2011. The presented with the typical features osteopetrosis: fractures after minor trauma, early tooth loss, anemia, hepatosplenomegaly, generalized increase mineral density (BMD). Aside from his father's complaint...
Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which involved tumorigenesis progression breast endometrial cancers.Our previous study has shown that protein levels SULT1E1 were decreased cancer; however, underlying mechanism still poorly understood.In this study, we explored functional molecular mechanisms by influenced cancer.Here, identified overexpression inhibited cancer cell growth...
Long noncoding RNA (LncRNA) H19 has been proven to be involved in many kinds of cancers including glioma, and a previous study shown an autophagy regulation H19. The mammalian target rapamycin (mTOR) signaling pathway plays key role Unc-51 like activating kinase 1 (ULK1) is also thought signaling. In our study, we investigated the mTOR/ULK1 H19-mediated promotion glioma proliferation. Human cells U87 U251 normal human astrocytes HA1800 were used study. First, expression was determined U87,...
Retinal ganglion cell (RGC) degeneration leads to irreversible blindness. Müller glia (MG) play pivotal roles in retinal homeostasis and disease through paracrine signaling. Small extracellular vesicles (sEVs) are bioactive nanomaterials derived from all types of live cells recognized as a potential strategy for neuroprotective therapy. The aim this study is investigate the MG-derived sEVs (MG-sEVs) mouse model optic nerve injury (ONC). It found that MG-sEVs treatment effectively mitigates...
The E3 ubiquitin ligase neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) negatively regulates phosphatase and tensin homolog deleted on chromosome 10 (PTEN) protein levels through polyubiquitination proteolysis, but its significance in lung cancer is still unclear. This study investigated the expression role of NEDD4-1 tumor development chemosensitivity adenocarcinoma (ADC).We retrospectively NEDD4-1, PTEN, p-Akt proteins 135 paired ADC adjacent noncancerous tissue...
Mammalian sterile 20-like kinase 1 (Mst1) has been proved in the process of apoptosis and tumor suppression. The aim study was to investigate expression Mst1 breast cancer evaluate its prognostic significance. examined 110 patients by immunohistochemistry, which 80 (72.7 %) were defined as positive for expression. Patients with negative had poor overall survival, comparing those using Kaplan-Meier survival analysis (P = 0.009). Multivariate Cox proportional hazards model showed that a...
Aberrant expression of long noncoding RNA cyclin-dependent kinase inhibitor 2B antisense 1 (CDKN2B-AS1) has been detected in human colorectal cancer (CRC). This study aimed to investigate the role CDKN2B-AS1 and underlying mechanism CRC. Gain- loss-of-function assays were performed explore malignant behavior HCT116 SW480 CRC cells vitro vivo. pull-down assay was conducted identify target cells. The physical functional interactions between examined. inhibited cell proliferation migration...
Mammalian sterile 20‑like kinase 1 (Mst1) is a major inhibitor of cell proliferation, and involved in apoptosis, oncogenesis organ growth via its ubiquitously encoded serine threonine kinase. Previous studies have demonstrated that Mst1 has tumor suppressor function human breast cancer. deletion or mutation associated with tumorigenesis, whereas overexpression leads to apoptosis decreases proliferation cells. Our previous study reported the suppressive Mst1, debated as prognostic factor In...
Enhancer RNAs (eRNAs) participate in tumor growth and immune regulation through complex signaling pathways. However, the immune-related function of eRNA-mRNA axis lung adenocarcinoma (LUAD) is unclear. Data on expression eRNAs mRNAs were downloaded from The Cancer Genome Atlas, GEO, UCSC Xena, including LUAD, pan-cancer clinical data mutational information. Immune gene files obtained ImmLnc ImmPort databases. Survival indices, relapse-free overall survival, analyzed using Kaplan–Meier...
Background Glucosylceramide synthase (GCS), an enzyme responsible for ceramide glycosylation, plays important role in multidrug resistance (MDR) some tumors vitro ; however, its expression and clinicopathological significance non-small cell lung cancer (NSCLC) remains unclear. Methods We evaluated GCS 116 paired tumor adjacent non-cancerous tissues 50 frozen from patients with NSCLC using immunohistochemistry western blotting, explored the correlation between characteristics prognosis....
// Feng Shi 1, * , Feng-Feng Cai 2, Lu 2 Xiao-Yan Lin Wei Zhang 1 Qin-Qin Wang Yu-Jie Zhao Qi-Chao Ni Hua and Zhi-Xian He Department of General Surgery, Affiliated Hospital Nantong University, Nantong, PR China Breast Yangpu Hospital, Tongji University School Medicine, Shanghai, These authors contributed equally to this work Correspondence to: He, email: hezhixian@ntu.edu.cn Wang, 13706292250@163.com Keywords: SYF2, breast cancer, proliferation, prognosis Received: January 10, 2017 Accepted:...
Esophageal cancer‑related gene 4 (ECRG4) is a candidate tumor suppressor gene, which involved in cell apoptosis, migration, infection and inflammation responsiveness; however, its expression level clinical significance hepatocellular carcinoma (HCC) remains unclear. In the present study, authors aim to evaluate potential role of ECRG4 HCC. Level protein HCC peripheral tissues was investigated tissue specimens obtained from 56 consecutive patients by immunohistochemistry. Cell proliferation,...