A5101934995- Photosynthetic Processes and Mechanisms
- Breast Cancer Treatment Studies
- Algal biology and biofuel production
- Microbial Community Ecology and Physiology
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced Breast Cancer Therapies
- Photoreceptor and optogenetics research
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Genomics and Phylogenetic Studies
- Breast Lesions and Carcinomas
- Cerebrovascular and Carotid Artery Diseases
- Spectroscopy and Quantum Chemical Studies
- MRI in cancer diagnosis
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Metabolomics and Mass Spectrometry Studies
- Selenium in Biological Systems
- Advanced Proteomics Techniques and Applications
- Cancer Cells and Metastasis
- Blood disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Neutropenia and Cancer Infections
Chongqing University
2011-2025
Chongqing Cancer Hospital
2017-2025
Anhui Xinhua University
2024
Guangzhou Xinhua University
2024
Guangdong University of Foreign Studies
2024
Yangtze Optical Electronic (China)
2023
Nanchang Institute of Technology
2022
Cancer Institute (WIA)
2017-2020
Tianjin University of Science and Technology
2014
Guhua Hospital
2012
The value of platinum-based adjuvant chemotherapy in patients with triple-negative breast cancer (TNBC) remains controversial, as does whether BRCA1 and BRCA2 (BRCA1/2) germline variants are associated platinum treatment sensitivity.To compare 6 cycles paclitaxel plus carboplatin (PCb) a standard-dose regimen 3 cyclophosphamide, epirubicin, fluorouracil followed by docetaxel (CEF-T).This phase randomized clinical trial was conducted at 9 centers hospitals China. Between July 1, 2011, April...
According to the climate emission reduction commitment of Paris Agreement, all countries are actively seeking a new path energy conservation and reduction, trying "bend downward" global greenhouse gas curve. For China's carbon peak before 2030 neutral target 2060, explore whether FDI can reduce consumption emissions. From research perspective quality, this paper explores potential ways improve regional energy-carbon performance (ECEP), applied dynamic threshold effect two-stage least squares...
Refractory or relapsing metastatic triple-negative breast cancer (mTNBC) has a poor prognosis. Sacituzumab govitecan (SG) is novel antibody-drug conjugate, targeting human trophoblast cell-surface antigen 2 (Trop-2). This the first report of SG's efficacy and safety in Chinese patients with mTNBC. EVER-132-001 (NCT04454437) was multicenter, single-arm, Phase IIb study mTNBC who failed ≥2 prior chemotherapy regimens. Eligible received 10 mg/kg SG on Days 1 8 each 21-day treatment cycle, until...
Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) is associated with favorable outcomes in breast cancer patients. Identifying reliable predictors for pCR can assist selecting patients who will derive the most benefit from NAC. The prognostic nutritional index (PNI) serves as an indicator of status and systemic immune competence. It has emerged a biomarker several malignancies; however, its predictive value remains uncertain. objective this study to assess pretreatment PNI
To evaluate the feasibility of using a multigene signature to tailor individualised adjuvant therapy for patients with operable triple negative breast cancer.
Breast cancer is now the most common malignant tumor worldwide. About one-fourth of female patients all over world suffer from breast cancer. And about one in six deaths worldwide caused by In terms absolute numbers cases and deaths, China ranks first world. The CACA Guidelines for Holistic Integrative Management Cancer were edited to help improve diagnosis comprehensive treatment China.
The PrrBA two-component regulatory system is a major global regulator in Rhodobacter sphaeroides 2.4.1. Here we have compared the transcriptome and proteome profiles of wild-type (WT) mutant PrrA2 cells grown anaerobically dark with dimethyl sulfoxide as an electron acceptor. Approximately 25% genes present genome are regulated by PrrA at transcriptional level, either directly or indirectly, twofold more relative to WT. affected widespread throughout all COG (cluster orthologous group)...
Introduction Breast cancer is the most common malignant tumor among women worldwide, and microenvironment (TME) has become a hot research field in contemporary oncology. Understanding TME essential for elucidating mechanisms of breast progression identifying novel therapeutic targets metastasis recurrence. This study performed bibliometric analysis cancer, providing comprehensive overview current hotspots, development trends, directions. Methods We retrieved literature on published during...
Neutropenia is a common complication from chemotherapy. Mecapegfilgramtim (code name HHPG-19K), long-acting recombinant human granulocyte colony-stimulating factor (rhG-CSF), has been developed. This study was to evaluate the efficacy and safety of mecapegfilgrastim for reducing neutropenia compared with filgrastim.This randomized, controlled non-inferiority study. A total 339 breast cancer patients who were eligible (neo) adjuvant chemotherapy randomized assigned into three groups receive...
A new operon (designated the puc2BA operon) displaying a high degree of similarity to original pucBA genes Rhodobacter sphaeroides 2.4.1 puc1) was identified and studied genetically biochemically. The puc2B-encoded polypeptide is predicted exhibit 94% identity with beta-apoprotein. puc2A-encoded be much larger (263 amino acids) than 54-amino-acid puc1A-encoded polypeptide. In first 48 acids there 58% acid sequence We found that expressed, DNA data suggested regulated by PpsR/AppA...
The high-throughput accurate mass and time (AMT) tag proteomic approach was utilized to characterize the proteomes for cytoplasm, cytoplasmic membrane, periplasm, outer membrane fractions from aerobic photosynthetic cultures of gram-nagtive bacterium Rhodobacter sphaeroides 2.4.1. In addition, we analyzed proteins within purified chromatophore that house apparatus photosynthetically grown cells. total, 8300 peptides were identified with high confidence at least one subcellular fraction...
ABSTRACT The TspO outer membrane protein of Rhodobacter sphaeroides has been shown to be involved in controlling the transcription a number genes which encode enzymes photopigment biosynthesis and puc operon. display regulated appears identical those encompassing PpsR/AppA repressor/antirepressor regulon, although effect is modest relative that PpsR/AppA. To directly address hypothesis effective through system, we constructed mutant strains with mutations both tspO appA . In all cases,...
Biological systems are in a continual state of flux, which necessitates an understanding the dynamic nature protein abundances. The study abundance dynamics has become feasible with recent improvements mass spectrometry-based quantitative proteomics. However, number challenges still remain related to how best extract biological information from proteomics data, for example, extraneous variability, missing values, and identification significant temporal patterns. This paper describes strategy...
The Rhodobacter sphaeroides intracytoplasmic membrane (ICM) is an inducible that dedicated to the major events of bacterial photosynthesis, including harvesting light energy, separating primary charges, and transporting electrons. In this study, multichromatographic methods coupled with Fourier transform ion cyclotron resonance mass spectrometry, combined subcellular fractionation, was used test hypothesis photosynthetic R. 2.4.1 contains a significant number heretofore unidentified proteins...
Doxorubicin (DOX) is currently one of the most widely used and effective drugs for treatment breast cancer, but drug resistance in cancer often leads to poor efficacy. MicroRNAs (miRNAs) are involved development progression various tumors increasing number studies have confirmed that abnormal miR-520b expression closely associated cancer. We analyzed clinical features, including miR-520b, 30 patients with Further, we interaction between insulin-like growth factor 1 receptor (IGF-1R) cell....
The mechanism by which light is converted into chemical energy in a natural photosynthetic system has drawn considerable research interest. Using fluorescence spectroscopy and microscopic imaging, we have observed fluctuating intermolecular protein resonant transfers (FRET) among light-harvesting proteins I II (LH1 LH2) bacterial membranes. two-channel, FRET, photon-counting detection novel, two-dimensional cross-correlation function amplitude-mapping analysis, revealed intensity spectral...