A5102872042- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- RNA Research and Splicing
- Rheumatoid Arthritis Research and Therapies
- Endoplasmic Reticulum Stress and Disease
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Cancer-related gene regulation
- Gut microbiota and health
- Exercise and Physiological Responses
- Traditional Chinese Medicine Studies
- Natural Compounds in Disease Treatment
- Hormonal Regulation and Hypertension
- PI3K/AKT/mTOR signaling in cancer
- Autoimmune and Inflammatory Disorders Research
- Cancer-related Molecular Pathways
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Pregnancy-related medical research
- Cancer Genomics and Diagnostics
Guangzhou University of Chinese Medicine
2024-2025
Harbin Medical University
2014-2025
First Affiliated Hospital of Harbin Medical University
2014-2025
Cancer Hospital of Shantou University Medical College
2015-2025
Shantou University
2016-2025
Peking University
2025
Peking University Cancer Hospital
2025
Guangdong Provincial Hospital of Traditional Chinese Medicine
2025
China Power Engineering Consulting Group (China)
2024
Shantou University Medical College
2016-2024
Abstract More and more evidence indicates that circular RNAs (circRNAs) have important roles in several diseases, especially cancers. However, their involvement remains to be investigated breast cancer. Through screening circRNA profile, we identified 235 differentially expressed circRNAs Subsequently, explored the clinical significance of two circTADA2As a large cohort triple-negative cancer (TNBC), performed functional analysis circTADA2A-E6 vitro vivo support findings. Finally, evaluated...
Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the interleukin-1 family. IL-33 binds to its receptor ST2 induce type 2 cytokines and exert both pro-inflammatory protective functions in host defense disease. Murine breast carcinoma models suggest disruption signaling may enhance anti-tumor immune response, suggesting impedes immunity. However, role patients with cancers (BC) not elucidated. We detected expression tumor tissue, related serum from BC patients....
// Li-Fang He 1, 2, * , Hong-Wu Xu 3, Min Chen Zhi-Rong Xian 2 Xiao-Fen Wen Min-Na Cai-Wen Du 4 Wen-He Huang 1 Jun-Dong Wu Guo-Jun Zhang The Breast Center, Cancer Hospital of Shantou University Medical College, 515041, Guangdong, China Changjiang Scholar Laboratory, 3 Department Neurosurgery, Second Affiliated Shantou, 515031, Oncology, These authors contributed equally to this work Correspondence to: Zhang, email: guoj_zhang@yahoo.com Keywords: p21-activated kinase (PAK4), prognostic...
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and predicts poor prognosis in various kinds cancers, including breast cancer. In order to further clarify Twist's role cancer, we detected Twist expression cancer tissues by immunohistochemistry. was observed 54% (220/408) patients positively tumor size, Ki67, VEGF-C HER2 expression. Conversely, negatively estrogen receptor (ER), progesterone...
Abstract Recent studies indicate that the long noncoding RNA ATB (lncATB) can induce epithelial−mesenchymal transition (EMT) in cancer cells, but specific cellular targets of lncATB require further investigation. In present study, upregulation breast cells was validated a TGF-β-induced EMT model. Gain- and loss-of-function demonstrated enhanced cell migration, invasion clonogenicity vitro vivo. LncATB promoted by acting as sponge for miR-200 family restoring Twist1 expression. Subsequently,...
Resistance to chemotherapy remains a significant problem in the treatment of breast cancer, especially for triple-negative cancer (TNBC), which standard systemic therapy is currently limited chemotherapeutic agents. Our study aimed better understand molecular mechanisms that lead failure TNBC. Herein, we observed elevated expression Notch1 and major vault protein (MVP) MDA-MB-231DDPR cells compared their parental counterparts. We demonstrated could positively regulate MVP. Also,...
Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized soluble epoxide hydrolase (sEH). EETs have been associated with cardiovascular disease, diabetes several cancer diseases. However, the distribution in tissue role of CYP2C8, 2C9, 2J2 sEH human breast carcinogenesis remains uncertain. Breast (BC) adjacent noncancerous was obtained 40 patients Chaoshan region China 2010 to 2012. The level 14,15-EET/14,15-DHET BC detected ELISA;...
Background S-phase kinase protein 2 (Skp2), an oncogenic protein, is a key regulator in different cellular and molecular processes, through ubiquitin-proteasome degradation pathway. Increased levels of Skp2 are observed various types cancer associated with poor prognosis. However, human breast carcinomas, the underlying mechanism prognostic significance cytoplasmic still undefined. Methods To investigate role expression we immnohistochemically assessed Skp2, p-Akt1, p27 251 patients invasive...
TFPI-2 has been recognized as a potent tumor suppressor gene. Low expression of results in enhanced growth and metastasis variety human tumors. In the present study, we investigated mechanism responsible for suppressive effect TFPI-2. Overexpression decreased phosphorylation ERK1/2 translocation p-ERK1/2 from cytoplasm into nucleus, eventually resulted reduced cell proliferation. Immunoprecipitation assays identified myosin-9 actinin-4 TFPI-2-interacting proteins. Full-length was required...
Notch4, a family member of the Notch signaling pathway, has important roles in cellular developmental pathways, including proliferation, differentiation and apoptosis. The present study aimed to investigate association between Notch4 expression clinical outcomes with immunohistochemistry. was expressed 55.6% triple-negative breast cancer (TNBC), 45.8% Her-2-overexpressing 25.5% luminal cases, significantly higher occurring TNBC (P<0.05). Furthermore, inversely associated estrogen receptor...
To investigate the expression patterns and prognostic values of STEAP family members in occurrence development breast cancer.The Human Protein Atlas was used to analyze level STEAPs human normal tissues malignant tumors. ONCOMINE datasets were analyzed for comparison levels between cancers corresponding tissues. Kaplan-Meier plotter value cancer patients.STEAPs widely distributed with diverse levels. Normally, it is predicted that STEAP1 STEAP2 involved mineral absorption process, while...
Metabolic syndrome (MS) is a growing public health problem worldwide. The clinical impact of fecal microbiota transplantation (FMT) from healthy donors in MS patients unclear, especially southern Chinese populations. This study aimed to investigate the effect washed (WMT) China.
Small nucleolar RNAs (snoRNAs) represent a class of non-coding that play pivotal roles in post-transcriptional RNA processing and modification, thereby contributing significantly to the maintenance cellular functions related protein synthesis. SnoRNAs have been discovered possess ability influence cell fate alter disease progression, holding immense potential controlling human diseases. It is suggested dysregulation snoRNAs cancer exhibits differential expression across various types,...
Notch3 and GATA binding protein 3 (GATA-3) have been, individually, shown to maintain luminal phenotype inhibit epithelial-mesenchymal transition (EMT) in breast cancers. In the present study, we report that expression positively correlates with of GATA-3, both are associated estrogen receptor-α (ERα) cancer cells. We demonstrate vitro vivo suppressed EMT metastasis by activating GATA-3 transcription. Furthermore, knockdown downregulated promoted EMT; while overexpression intracellular...
// Guangli Wang 1, * , Zhenqiang Huang Xin Liu 1 Wenhe 2 Shaoying Chen Yanchun Zhou Deling Li Robert H. Singer 3 Wei Gu Department of Pathophysiology, The Key Immunopathology Laboratory Guangdong Province, Shantou University Medical College, Shantou, 515031, China Tumor Hospital, Anatomy and Structural Biology, Albert Einstein College Medicine, Bronx, NY 10461, USA These authors have contributed equally to this work Correspondence to: Gu, e-mail: weigu1@yahoo.com Keywords: breast cancer...
Oral squamous cell carcinoma (OSCC) is a solid tumor, which originates from epithelium, with about 400,000 new-cases/year worldwidely. Presently, chemoradiotherapy the most important adjuvant treatment for OSCC, mostly in advanced tumors. However, clinical resistance to chemotherapy still leads poor prognosis of OSCC patients. Via high-throughput analysis gene expression database we investigated molecular mechanisms underlying cisplatin analyzing differentially expressed genes (DEGs) and...