A5101763036- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Skin and Cellular Biology Research
- Bone health and osteoporosis research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes and associated disorders
- Natural product bioactivities and synthesis
- Thyroid Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Plant-based Medicinal Research
- Diet and metabolism studies
- melanin and skin pigmentation
- Phytochemistry and Biological Activities
- Cell Adhesion Molecules Research
- Nutritional Studies and Diet
- Biomarkers in Disease Mechanisms
- Plant Parasitism and Resistance
- Cellular Mechanics and Interactions
- Growth Hormone and Insulin-like Growth Factors
- Plant Diversity and Evolution
- Lipoproteins and Cardiovascular Health
- Biological and pharmacological studies of plants
- Phytochemistry and biological activity of medicinal plants
- Plant Ecology and Taxonomy Studies
- Neuroscience of respiration and sleep
Jiangxi Normal University
2025
Third Hospital of Nanchang
2013-2023
Xihua University
2022
Nanchang University
2021
Second Affiliated Hospital of Nanchang University
2021
Zunyi Medical University
2013-2016
Southern Medical University
2014-2015
Mudanjiang Medical University
2007-2009
Peking University
2007-2009
Peking University First Hospital
2007
The terrifying undiagnosed rate and high prevalence of diabetes have become a public emergency. A efficiency cost-effective early recognition method is urgently needed. We aimed to generate innovative, user-friendly nomograms that can be applied for screening in different ethnic groups China using the non-lab or noninvasive semi-lab data.This multicenter, multi-ethnic, population-based, cross-sectional study was conducted eight sites by enrolling subjects aged 20-70. Sociodemographic...
Objective: We investigated the relationship between thyroid hormones and risk of diabetic kidney disease (DKD) progression. Methods: A total 452 patients with type 2 diabetes were included, a cross-sectional analysis was performed. Urine albumin/creatinine ratio (ACR) estimated glomerular filtration rate (eGFR) used to diagnose persistent albuminuria stage chronic disease, respectively. The Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline describe DKD progression...
Consumers are increasingly engaging in green consumption practices through the lens of self-quantification. Both pursuit positive data outcomes at individual level and comparison even competition among community may lead to insincere behaviors such as “performative engagement” beyond tracking measuring one’s consumption. Compared outcome-oriented studies exploring impact self-quantification on consumers’ behaviors, this research focuses deeper sincerity outcomes, comprehensively analyzing...
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes explore relationships between serum insulin resistance. A total 271 unrelated Chinese were recruited study. subjects divided into type 2 mellitus (T2DM) group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>93</mml:mn></mml:math>), impaired glucose regulation (IGR)...
Diabetes mellitus is associated with an increased risk of breast cancer, but the molecular mechanism underlying this association remains unclear. The aim present study was to investigate effect high glucose and insulin conditions on MCF‑7 cancer cells elucidate mechanisms these effects. High resulted in viability, proliferation, invasion compared normal low conditions. Reverse transcription‑quantitative polymerase chain reaction western blot analyses revealed that receptor substrate 1 (IRS1)...
Abstract The aim of the present study was to explore influence tea consumption on diabetes mellitus in Chinese population. This multi-centre, cross-sectional conducted eight sites from south, east, north, west and middle regions China by enrolling 12 017 subjects aged 20–70 years. Socio-demographic general information collected a standardised questionnaire. A standard procedure used measure anthropometric characteristics obtain blood samples. diagnosis determined using 75-g oral glucose...
Lipid abnormalities are associated with overweight and obesity. Some simple anthropometric measurements such as body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), waist-to-height (WHtR), may link to increased risk of dyslipidemia. However, diverse results were found in different population studies. We focused on the associations between these dyslipidemia non-obese (BMI <28kg/m2) aged more than 40 years.Cross-sectional study 4185 adults years was conducted Nanchang,...
Reducing the expression of endothelial cell adhesion molecules (ECAMs) is known to decrease inflammation-induced vascular complications. In this study, we explored whether rhein can reduce ECAMs in human umbilical vein cells (HUVECs) with or without lipopolysaccharide (LPS) stimulation. HUVECs were treated different concentrations 2.5 μg/ml LPS Cell viability was assayed using MTT method. Real-time PCR and Western blot analysis used measure transcription levels ECAMs, including intercellular...
Autosomal recessive lamellar ichthyosis (LI) is a severe skin disorder characterized by generalized hyperkeratosis. Gene mutation in transglutaminase 1 (TGM1), which mediates cross-links the formation of cell envelope during terminal differentiation epidermis, has been identified as cause LI.To determine mutations TGM1 gene three Chinese families with LI.The was sequenced to identify disease-causing LI. One results confirmed using reverse transcriptase PCR and situ hybridization. An (TGase)...
The protective effect of rhein lysinate (RHL) on Alzheimer's disease (AD) was explored in senescence-accelerated mouse prone-8 (SAMP8) mice. SAMP8 mice without treatment were used as the AD-positive control, and senescence-accelerated-resistant AD-negative control. In this study, 4-month-old male orally administered 25 50 mg/kg RHL drinking water for 6 months. results brain tissue enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, Western blot demonstrated that compared with...
Objective: To compare the risk of osteoporotic fractures between urban and urban-rural fringe populations in southern China to explore effect bone turnover markers on fracture risk. Methods: Epidemiological investigations were conducted areas June 2018. Residents aged 40 years over who signed informed consent forms included. Physical examination questionnaire collection completed. Bone (BTMs) including osteocalcin (OC) beta cross-linked C-telopeptide type 1 collagen (β-CTX) tested. mineral...
Diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN) are both common chronic complications of type 2 diabetes mellitus (T2DM). The aim this study was to examine whether some markers early renal injury were associated with DPN.
In a previous study, we confirmed that netrin-1 acts as an antiangiogenic factor by inhibiting alkali burn-induced corneal neovascularization in rats. Here, continue working on the role of retinal neovascularization.Using vitro angiogenesis assay, detected effects human umbilical vein endothelial cell tube formation, viability and proliferation, migration, invasion at concentrations 0.1 μg/mL or 5 μg/mL. We intravitreally injected into streptozotocin-induced rats to assess using...
Age at menarche (AAM) and age natural menopause (AANM) have been shown intimately associated with woman's health later in life. Previous studies indicated that AAM AANM are highly heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which also found post-menopausal hormone-related diseases. The aim of this study was to evaluate associations between the polymorphisms TNFSF11, TNFRSF11A TNFRSF11B genes Chinese women.Post-menopausal women (n = 845) aged from...
Receptor activator of nuclear factor-kappa B ligand (RANKL), its receptor (RANK), and decoy osteoprotegerin (OPG) are three major proteins the RANKL/RANK/OPG signaling pathway encoded by TNFSF11, TNFRSF11A, TNFRSF11B, respectively. This plays a critical role in bone remodeling may have pathogenesis type 2 diabetes mellitus (T2DM). The aim this study was to investigate relationship between gene polymorphisms T2DM Southern Han Chinese women.A total 1233 participants, including 514 patients 719...
Netherton's syndrome is a rare autosomal recessive disorder caused by mutations of the SPINK5 gene, which encodes lymphoepithelial Kazal-type-related inhibitor (LEKTI) protein. We observed microstructural changes and detected LEKTI activity gene mutation in three Chinese patients with syndrome. Decreased was found skin patients. Lamellar bodies foci electron-dense material were intercellular spaces stratum corneum. A novel homozygous splicing 1430+2 T-->G one proband. No other family.
In a previous study, it was demonstrated that Rhein lysinate (RHL) inhibited HeLa cell proliferation via specific mechanism. The aim of the present study to clarify mechanism RHL by investigating its effect on mitochondrial damage and apoptosis. results indicated growth in cells. cells treated with developed extensive vacuolization dose- time-dependent manner. Ultrastructure analysis using transmission electron microscopy revealed vacuoles observed were damaged mitochondria endoplasmic...