A5101891202- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Risk Factors
- X-ray Diffraction in Crystallography
- Biomarkers in Disease Mechanisms
- Advanced Nanomaterials in Catalysis
- Cancer-related gene regulation
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- Nanocluster Synthesis and Applications
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Vanadium and Halogenation Chemistry
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Supramolecular Self-Assembly in Materials
- Catalytic C–H Functionalization Methods
- Transgenic Plants and Applications
- Lipoproteins and Cardiovascular Health
Third Hospital of Nanchang
2013-2024
National Health and Family Planning Commission
2024
National Clinical Research
2024
Shanghai Jiao Tong University
2024
Taiyuan Iron and Steel Group (China)
2024
Henan University
2024
South China University of Technology
2022
Shanxi Eye Hospital
2021
First Affiliated Hospital of Xi'an Jiaotong University
2019
Nanfang Hospital
2016
BackgroundEffective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear.MethodsWe enrolled 50 years of age or older diabetes, elevated blood pressure, and an increased risk cardiovascular disease at 145 clinical sites across China. Patients were randomly assigned to receive intensive treatment that targeted a pressure less than 120 mm Hg standard 140 up 5 years. The primary outcome was composite nonfatal stroke, myocardial infarction, hospitalization...
Ultrasensitive and accurate monitoring of carboxylesterase (CE) activity is extremely crucial for the early diagnosis hepatocellular carcinoma (HCC), which still a considerable challenge. Herein, using co-reactive ligand engineering strategy, ultra-bright near-infrared (λmax = 830 nm) self-enhanced electrochemiluminescence (ECL) Au nanoclusters (NCs) were in situ prepared with 2-(diethylamino) ethanethiol (DEAET) as ligand. Remarkably, not only acts stabilizer like traditional ligands but...
Organic anion transporter 1 (OAT1) mediates the body disposition of a diverse array environmental toxins and clinically important drugs. Therefore, understanding regulation this has profound clinical significance. We previously demonstrate that OAT1 activity was down-regulated by activation protein kinase C (PKC), kinetically revealed as decrease in maximum transport velocity Vmax without significant change substrate affinity Km transporter. In current study, we showed constitutively...
Ferroptosis is a form of programmed cell death that participates in the progression numerous diseases. Long noncoding RNAs (lncRNAs) are dysregulated diabetic retinopathy (DR). However, role lncRNAs DR-induced ferroptosis unclear. Adult retinal pigment epithelial line-19 (ARPE19) cells were treated with high concentration glucose (high glucose, HG) to mimic DR vitro. The intracellular contents glutathione, malondialdehyde, and ferrous ions analyzed using corresponding kits. MTT assay was...
// Zhi-hua Li 1 , Qiu-yun Xiong Liang Xu Peng Duan 2 Qianwen Ou Yang Ping Zhou Jian-hong Tu 3 Prevention and Cure Center of Breast Disease, The Third Hospital Nanchang City, Key Laboratory Diseases in Jiangxi Province, Nanchang, JiangXi 330009, People's Republic China Department Endocrinology, Diabetes, Pathology Department, Specialist Hospital, Correspondence to: Li, email: huazhili0802@163.com Xiong, xqy6235100@163.com Keywords: MiR-29a, breast cancer, insulin signaling pathway, cell...
Objective: We investigated the relationship between thyroid hormones and risk of diabetic kidney disease (DKD) progression. Methods: A total 452 patients with type 2 diabetes were included, a cross-sectional analysis was performed. Urine albumin/creatinine ratio (ACR) estimated glomerular filtration rate (eGFR) used to diagnose persistent albuminuria stage chronic disease, respectively. The Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline describe DKD progression...
The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes explore relationships between serum insulin resistance. A total 271 unrelated Chinese were recruited study. subjects divided into type 2 mellitus (T2DM) group (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>93</mml:mn></mml:math>), impaired glucose regulation (IGR)...
Diabetes mellitus is associated with an increased risk of breast cancer, but the molecular mechanism underlying this association remains unclear. The aim present study was to investigate effect high glucose and insulin conditions on MCF‑7 cancer cells elucidate mechanisms these effects. High resulted in viability, proliferation, invasion compared normal low conditions. Reverse transcription‑quantitative polymerase chain reaction western blot analyses revealed that receptor substrate 1 (IRS1)...
Lipid abnormalities are associated with overweight and obesity. Some simple anthropometric measurements such as body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHpR), waist-to-height (WHtR), may link to increased risk of dyslipidemia. However, diverse results were found in different population studies. We focused on the associations between these dyslipidemia non-obese (BMI <28kg/m2) aged more than 40 years.Cross-sectional study 4185 adults years was conducted Nanchang,...
Placental growth factor (PlGF) related signaling pathway has been shown to have close relationship with the progression of cancers. Metformin reported an inhibitory effect on PlGF expression in a breast cancer model. However, little is known about whether anti-neoplastic activity metformin contributed by its expression. Protein, mRNA and secretion levels were tested proliferation cells was determined. After treatment metformin, BALB/c mice bearing 4T1 tumors sacrificed immunohistochemistry...
The protective effect of rhein lysinate (RHL) on Alzheimer's disease (AD) was explored in senescence-accelerated mouse prone-8 (SAMP8) mice. SAMP8 mice without treatment were used as the AD-positive control, and senescence-accelerated-resistant AD-negative control. In this study, 4-month-old male orally administered 25 50 mg/kg RHL drinking water for 6 months. results brain tissue enzyme-linked immunosorbent assay (ELISA), immunohistochemistry, Western blot demonstrated that compared with...
ABSTRACT Objective This study aims to evaluate the association between body mass index (BMI) and incidence of breast cancer‐related lymphedema (BCRL). Methods retrospective cohort analyzed data from 1464 cancer patients treated at The Third Hospital Nanchang 2018 2021. Patients were categorized based on BMI (<25, 25 < 30, ≥ 30 kg/m²). Variables such as axillary lymph node dissection, infections, radiotherapy, comorbidities taken into account. Results BCRL was 23.4%. Higher associated...
Via difunctionalization of the α- and β-sites cyclic ethers, we herein demonstrate a new synthetic method for efficient construction novel fluorinated γ-amino acid esters by employing CoBr2/m-CPBA catalyst system. Several ethers were transformed in combination with vast range amines ethyl trifluoropyruvate into desired products under mild conditions, making this practical platform to enrich library amino derivatives from cost-effective readily available feedstocks.
Via a copper-catalyzed three-component annulation reaction, we herein report new method for the direct and syn-selective construction of cyclic ether-fused tetrahydroquinolines from readily available secondary anilines, saturated five or six-membered ethers, paraformaldehyde. The synthesis features operational simplicity, excellent step atom efficiency, good functionality substrate compatibility. In comparison with reported synthetic protocols capable synthesizing N-alkyl fused...
Age at menarche (AAM) and age natural menopause (AANM) have been shown intimately associated with woman's health later in life. Previous studies indicated that AAM AANM are highly heritable. RANKL/RANK/OPG signaling pathway is essential for mammary gland development, which also found post-menopausal hormone-related diseases. The aim of this study was to evaluate associations between the polymorphisms TNFSF11, TNFRSF11A TNFRSF11B genes Chinese women.Post-menopausal women (n = 845) aged from...