By comparing the expression profiles of microRNAs (miRNAs) in different hepatocellular carcinoma (HCC) subtypes, we identified miR-140-5p as an HCC-related miRNA. We found that was significantly decreased HCC tissues and all six liver cancer cell lines examined its levels were correlated with multiple nodules, vein invasion, capsular formation, differentiation, well overall disease-free survival HCC. also suppressed proliferation metastasis. Multipathway reporter arrays suggested inhibited...

Hepatocellular carcinoma (HCC) is a highly invasive tumor with frequent intrahepatic or pulmonary metastasis, which the main reason for high recurrence and poor survival of HCC after liver resection. However, mechanisms metastasis remain incompletely clear. Given that microRNAs (miRNAs) are implicated in progression, we explored potential role miRNAs by performing miRNA expression profiling three subtypes different metastatic potentials. We discovered miR-331–3p as one most significantly...

Abstract Purpose: Hepatocellular carcinoma (HCC) harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. However, the mechanisms metastasis remain incompletely clear. This study aimed to investigate role of hsa-miR-487a (miR-487a) in promoting proliferation HCC elucidate underlying molecular mechanisms. Experimental Design: 198 samples were analyzed association between miR-487a expression patient clinicopathological features prognosis. The roles...

Abstract Backgrounds Papillary thyroid cancer (PTC), which is often driven by acquired somatic mutations in BRAF genes, the most common pathologic type of cancer. PTC has an excellent prognosis after treatment with conventional therapies such as surgical resection, hormone therapy and adjuvant radioactive iodine therapy. Unfortunately, about 20% patients develop regional recurrence or distant metastasis, making targeted therapeutics important option. Current vitro models are limited...

// Hao Yang 1, 2, * , Wei Zheng Xiao Shuai 1 Rui-Min Chang Lei Yu Feng Fang Lian-Yue 3 Liver Cancer Laboratory, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China 2 Department of Geratic Surgery, These authors have contributed equally to this work Correspondence to: Lianyue Yang, e-mail: lianyueyang@hotmail.com Keywords: hepatocellular carcinoma, miR-424, Akt3, E2F3, tumor growth Received: February 27, 2015 Accepted: July 23, Published: August 03, ABSTRACT By comparing...

Age-related macular degeneration (AMD) is a complex multifactorial disease with significant genetic component. Despite extensive research efforts, the underlying molecular mechanisms remain elusive, necessitating innovative approaches to identify specific genes involved in pathogenesis of AMD and elucidate their functional mechanisms. A transcriptome-wide association study (TWAS) was conducted by integrating eQTL data from 49 tissues Genotype-Tissue Expression Project (GTEx) v8 FinnGen R10....

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths owing to its high rate postoperative recurrence and metastasis. New research continuously identifying novel metastasis-associated oncogenes tumor suppressor genes. miRNAs are noncoding RNAs that regulate protein synthesis post-translationally. miR-130b one several involved in However, the role HCC remains controversial. Here, we demonstrate highly expressed it correlates with number, vascular invasion, TNM...

Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. A previous study has found that propofol can inhibit invasion and induce apoptosis ovarian cells. However, underlying mechanisms are not known. miR-9 been reported to be little expressed in cells, which related a poor prognosis patients with cancer. Studies have also demonstrated could microRNAs expression suppress NF-κB activation some situations. In present study, we assessed whether...

Abstract Background Even though immunotherapy has been an effective treatment for solid tumors, its efficacy in osteosarcoma remains sub‐optimal. It is therefore imperative to understand the complex tumor microenvironment (TME) of facilitate development immunotherapies against this cancer. Methods The mRNA expression profiles tissues were downloaded from Cancer Genome Atlas (TCGA) database. Next, ssGSEA, MCP‐counter, CIBERSORT, and Xcell algorithm analyses performed characterize tissues....

Study Design. Rat nucleus pulposus (NP) cells were activated with resistin or without p38 mitogen-activated protein kinase (MAPK) pathway inhibition. The expression of a disintegrin and metalloprotease thrombospondin motif-5 (ADAMTS-5), which plays an important role in intervertebral disc degeneration (IDD), was determined. Objective. aim this study to demonstrate whether can influence the ADAMTS-5 further investigate underlying mechanisms. Summary Background Data. Obesity has been...

A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm Shandong Province, China, its genome sequenced. This has been using the VR-2332 vaccine to immunize for long time. The phylogenic single nucleotide polymorphisms (SNPs) analysis of viruses dead showed that SD2020 natural recombinant virus JXA1 similar strain, two splicing fragments homologous were probably derived wild JXA1-R respectively....

Background and aims The aim of the present study was to evaluate serum Dickkopf-1 (Dkk-1) as a marker for early detection hepatocellular carcinoma (HCC), well prognostic prediction HCC after hepatic resection. Methods One-hundred four cases matched fresh tissue specimens adjacent non-tumorous liver (ANLT) were obtained RT-PCR, qRT-PCR, western blot immunohistochemistry assays. Sera collected from patients with (n=184), benign tumors (n=29), cirrhosis (n=174), non-cirrhotic hepatitis B...

BACKGROUND Stress‐activated protein kinase (SAPK) interacting 1 (SIN1) is essential for early embryonic development and the key regulator of Akt, which plays an important role in various pathological conditions such as cancer. However, biological function clinical significance SIN1 hepatocellular carcinoma (HCC) remains unknown. METHODS Real‐time quantitative reverse‐transcriptase polymerase chain reaction analysis, western blot immunohistochemical staining were used to test expression level...

Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role invasion and metastasis. Actin-like 6A (ACTL6A) vital for embryogenesis differentiation also critical metastasis EMT hepatocellular carcinoma, as observed our previous study. In present study, we further explored ACTL6A cancer metastasis.ACTL6A expression levels were analyzed normal colon, adenoma specimens using public databases tissue samples....

Tumor necrosis factor-α (TNF-α) has been shown to have a catabolic effect on intervertebral disc degeneration (IVDD), including increasing MMP3 expression and subsequent extracellular matrix (ECM) degradation. In contrast, transforming growth factor-β1 (TGF-β1) an anabolic nucleus pulposus (NP) cells. However, the anti-catabolic of TGF-β1 under inflammatory condition is unknown. The aim this study was demonstrate whether can reverse TNF-α-induced increase in NP cells further investigate...

Transmembrane protein 100 (TMEM100) was activated by ALK1/TGF-β signaling. We found that TMEM100 decreased in hepatocellular carcinoma (HCC) tissues and highly metastatic cell lines. Overexpressed of inhibited invasion, migration proliferation. Low levels were associated with cirrhosis, tumor size, Tumor nodule number, TNM stage, BCLC Edmondson-Steiner Stage vein invasion. Furthermore, an independent risk factor for overall survival (P = 0.03) disease-free 0.019). The current findings...

Background: Low back pain (LBP) is the leading cause of disability among elderly, placing significant social and economic burdens on societies globally. A common chronic LBP lumbar disc degeneration. Previously, we reported that autologous or allogenic fibroblast injections could treat intervertebral degeneration (IVDD) in preclinical studies by maintaining height stability through fibrosis. However, pathway to successful drug development remains unclear. Methods: To develop a novel human...

In Brief Study Design. A retrospective and radiological study of degenerative spinal diseases. Objective. To explore the changes in spinopelvic sagittal alignment after lumbar instrumentation fusion Summary Background Data. Efforts have been paid to clarify ideal postoperative profile for However, little has published about actual lordosis reconstruction. Methods. Radiographical analysis 83 patients with degeneration was performed by measuring parameters before operations. Comparative...

Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus that are usually stagnant in the inflammatory phase. However, oral wound healing, which characterized by rapid scarless healing process, regarded an ideal model healing. Thus, we performed comprehensive bioinformatics analysis previously published data regarding ulcers DFUs found compared to activated pathways were enriched cellular metabolism-related but lacked activation immune-related pathways. We...