A5102715153- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- Renal and Vascular Pathologies
- Organ Transplantation Techniques and Outcomes
- Cytomegalovirus and herpesvirus research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Blood groups and transfusion
- Polyomavirus and related diseases
- Sarcoma Diagnosis and Treatment
- Vasculitis and related conditions
- Ovarian cancer diagnosis and treatment
- Systemic Lupus Erythematosus Research
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Hepatocellular Carcinoma Treatment and Prognosis
- Rheumatoid Arthritis Research and Therapies
- Hernia repair and management
- Parvovirus B19 Infection Studies
- Soft tissue tumor case studies
- Transplantation: Methods and Outcomes
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Viral-associated cancers and disorders
Regend Therapeutics (China)
2025
Yang Hospital
2025
Huazhong University of Science and Technology
2024
China Medical University Hospital
2022-2024
China Medical University
2022-2024
Union Hospital
2024
Taichung Veterans General Hospital
2014-2023
Chung Shan Medical University
2006-2022
Weatherford College
2021-2022
Hungkuang University
2007-2015
<b>Objective:</b> To determine the type 1 T helper (Th1)/type 2 (Th2) balance in peripheral blood (PB) and pathological tissues of patients with active untreated adult onset Still's disease (AOSD). <b>Methods:</b> The percentages interferon γ (IFNγ)- interleukin (IL)4-producing Th cells PB 20 AOSD, rheumatoid arthritis (RA), healthy controls were determined by intracellular staining flow cytometry. Serum levels IL18 soluble IL2 receptor measured enzyme linked immunosorbent assay. Levels IFNγ...
To examine the feasibility of a real "blood transfusion"-free hepatectomy in large group patients with liver tumors.
We studied histological features and long-term outcomes in patients with progressive familial intrahepatic cholestasis type 1 (PFIC1) after liver transplantation (LT). Histological findings were correlated the post-LT course treatment 11 recipients PFIC1. Ages at LT varied from to 18 years (median, 4 years). Macrovesicular steatosis was observed 8 a median of 60 days (range, 21-191 days). Severe progressed steatohepatitis 7 161 116-932 The followed up for 7.3 2.3-16.1 Six showed bridging...
The protective effect of combination therapy with valsartan and aliskiren against renal fibrosis remains to be defined. This study was undertaken examine the effects induced by unilateral ureteral obstruction (UUO). Combination (15 mg·kg(-1)·day(-1)) (10 mg·kg(-1)·day(-1)), monotherapy (30 (20 all significantly ameliorated increase in blood urea nitrogen degree hydronephrosis determined weight length obstructed kidney. dose titration pressure measurement confirmed that provided a greater...
BCOR-CCNB3 sarcoma is a genetically defined undifferentiated malignancy with Ewing (ES)-like round cells, and preferentially affects the bones of male adolescents. Sarcomas harbouring rarely arise from soft tissues; therefore, we aimed to report four cases expand clinicopathological spectrum.By reverse transcription polymerase chain reaction confirmatory sequencing, detected transcript in primary sarcomas deep musculature patients, comprising two teenagers (aged 14 17 years) adults 34 44...
Abstract A renal allograft transplant patient with tubulointerstitial nephritis was examined for possible involvement of human polyomaviruses. Biopsy the kidney revealed inflammatory interstitial infiltration tubulitis and typical inclusion bodies in nucleus tubulo‐epithelium. Glomeruli showed duplication lamination Bowman's capsule enlargement parietal visceral epithelia. Immunohistochemical analysis on graft section using a JC virus (JCV) VP1 peptide‐specific antibody positive staining....
We report a unique case of combined primary neuroendocrine carcinoma (NEC) and hepatocellular (HCC) the liver in 65-year-old male patient. The patient underwent segmental resection regional lymph node dissection for tumor mass that measured 7.5 cm diameter right lobe, with lymphadenopathy. Histologically, hepatic was composed predominantly small-cell NEC, but admixed small island moderately differentiated HCC. speculate NEC originated from poorly clone an HCC differentiation, this now at end...
Diabetic nephropathy is characterized as the progressive development of renal insufficiency in a setting hyperglycemia. Previous studies indicate that reactive oxygen species (ROS) play an important role high glucose-induced injury. Cilostazol was reported to lower production superoxide significantly situ. We hypothesized cilostazol administration streptozotocin-induced diabetic rats exerts effects via improving oxidative stress. Male Sprague–Dawley were fed with (5 mg/kg or 25 mg/kg) for 12...
Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. IL-17 critical in inflammation, but role liver fibrosis has not yet been elucidated. In this study, we investigate on bile duct ligation-induced injury and C57BL/6 mice. Animals were sacrificed at designated times, serum tissues collected for analysis function IL-6, IL-1β, tumour necrosis factor-alpha (TNF-α) transforming growth factor-β (TGF-β) levels. blockade with anti-IL-17A mAb significantly...
Tumor-infiltrating lymphocytes (TILs) have emerged as a prognostic marker in endometrial cancer (EC). However, the role of TILs EC with distinct histology grades and molecular types (such mismatch repair [MMR] deficiency) has not yet been made clear. We retrospectively included 237 patients primary who underwent standard staging operation laparoscopic or laparotomy total hysterectomy bilateral salpingo-oophorectomy for analyses. An independent pathologist was blind to study patients'...
Background: Low back pain (LBP) is the leading cause of disability among elderly, placing significant social and economic burdens on societies globally. A common chronic LBP lumbar disc degeneration. Previously, we reported that autologous or allogenic fibroblast injections could treat intervertebral degeneration (IVDD) in preclinical studies by maintaining height stability through fibrosis. However, pathway to successful drug development remains unclear. Methods: To develop a novel human...
Abstract Primary renal lymphoma is a rare malignancy, and its occurrence in patients undergoing maintenance haemodialysis even more uncommon. Herein, we report the case of 57-year-old woman haemodialysis, presenting with gross haematuria. After performing enhanced magnetic resonance imaging, positron emission tomography-computed tomography, kidney biopsy, diffuse large B-cell was detected. She subsequently treated five cycles modified R-CHOP regimen consisting rituximab, cyclophosphamide,...
Abstract Interstitial inflammation scoring is incorporated into the Banff Classification of Renal Allograft Pathology and essential for diagnosis T-cell mediated rejection. However, its reproducibility, including inter-rater intra-rater reliabilities, has not been carefully investigated. In this study, eight renal pathologists from different hospitals independently scored 45 kidney allograft biopsies with varying extents interstitial inflammation. Inter-rater reliabilities were investigated...
Abstract A renal allograft transplant patient with high serum creatinine presented clinical symptoms of rejection. Sections biopsy tissue showed mononuclear leukocyte infiltration in the tubulointerstitium and nuclear enlargement inclusions tubular epithelium. The morphological characteristics resembled polyomavirus‐induced interstitial nephritis. Electron microscopy paracrystalline arrays naked viral particles a diameter 45 nm. Molecular studies revealed that new variant BK virus (BKV)...
Idiopathic membranous nephropathy (MN) is one of the most common causes nephrotic syndrome in adults, and 25% MN patients proceed to end-stage renal disease. Plasminogen activator inhibitor type 1 (PAI-1) activity plays an important role fibrosis. The objective this study was clarify relationship between PAI-1 gene polymorphisms progression MN-associated pathologies.We recruited a cohort 104 biopsy-diagnosed 142 healthy subjects that served as controls. Genotyping performed using...