A5035548891- Traditional Chinese Medicine Analysis
- Analytical Chemistry and Chromatography
- Thyroid Cancer Diagnosis and Treatment
- Phytochemistry and Biological Activities
- Metabolomics and Mass Spectrometry Studies
- Analytical Methods in Pharmaceuticals
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
- Chromatography in Natural Products
- MicroRNA in disease regulation
- Electrochemical sensors and biosensors
- Flavonoids in Medical Research
- Analytical Chemistry and Sensors
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Alcohol Consumption and Health Effects
- Saffron Plant Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Drug-Induced Hepatotoxicity and Protection
China Pharmaceutical University
2014-2024
Shanghai Institute of Materia Medica
2018-2024
Chinese Academy of Sciences
2009-2024
Third Affiliated Hospital of Southern Medical University
2024
Shandong Academy of Agricultural Sciences
2014-2023
Institute of Plant Protection
2012-2023
XinHua Hospital
2011-2023
Shanghai Jiao Tong University
2011-2023
Tianjin Medical University Cancer Institute and Hospital
2016-2022
Nanjing Medical University
2019-2022
Abstract Although humic acid has been demonstrated to improve the quality of some soil types, long-term effects on under continuous cropping peanut are not fully understood. This study aimed investigate physicochemical properties, microbial diversity, and enzyme activities peanut. In this study, a three-year consecutive experiment was conducted in North China Plain. addition equal nitrogen, phosphorus, potassium inputs, treatment applied with inorganic fertilizers. Compared control...
Abstract Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70–90% primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis unsatisfactory due to high metastasis and/or post-surgical recurrence rates. Therefore, new therapeutic methods for inhibiting and urgently needed. Exosomes small lipid-bilayer vesicles that implicated in tumour development metastasis. Rab27a, a GTPase, regulates exosome secretion by mediating...
To evaluate and compare the clinical pathologic characteristics outcomes after hepatic resection of large hepatocellular carcinoma (SLHCC), small HCC (SHCC), nodular (NHCC).Traditional viewpoint insists that classification prognosis are determined by size HCC. As a result, is often considered as advanced unresectable. However, we have observed unique type HCC-SLHCC, which in but exhibits good clinical, pathologic, molecular biologic well prognosis.From January 1992 to December 2002, total...
Abstract BACKGROUND: Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function HSF1 in hepatocellular carcinoma (HCC) remain unknown. METHODS: Quantitative reverse transcriptase‐polymerase chain reaction analysis, Western blot immunohistochemical staining were used to detect expression levels HSF1, its correlation with clinicopathologic parameters prognosis for patients HCC analyzed. In addition, molecular...
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven T790M mutation. The discovery third-generation inhibitors overcoming and their new mechanisms have attracted much attention.We examined antitumor activities potential mechanism a novel inhibitor in vitro vivo using ELISA, SRB assay, immunoblotting, flow cytometric analysis, kinase array,...
Single-cell proteomics offers unparalleled insights into cellular diversity and molecular mechanisms, enabling a deeper understanding of complex biological processes at the individual cell level. Here, we develop an integrated sample processing on active-matrix digital microfluidic chip for single-cell (AM-DMF-SCP). Employing AM-DMF-SCP approach data-independent acquisition (DIA), identify average 2258 protein groups in single HeLa cells within 15 min liquid chromatography gradient. We...
The simple homogeneous N-acetylating reaction was developed for preparation of chitosans with various degree deacetylation (DDA). Water-soluble half N-acetylated chitosan powders were characterized by IR, CP/MAS-13CNMR, XRD and thermal analysis. results show the presents higher water hold capacity, lower crystallinity stability in contrast to original 91% DDA, which may be explained differences intermolecular hydrogen bonding. influences DDA on crystalline properties, mechanical swelling...
Sorafenib is recognized as a standard treatment for advanced hepatocellular carcinoma (HCC). However, many patients have to adopt dose reduction or terminate the use of sorafenib because side effects. In addition, large number are resistant sorafenib. Thus, it essential investigate underlying mechanisms resistance and seek potential strategy enhance its efficacy. The protein expression hypoxia-inducible factors (HIF)-2α, 30-kDa HIV Tat-interacting (TIP30), E-cadherin, N-cadherin, pAMPK was...
In this paper, we describe the discovery and optimization of a series noncovalent reversible epidermal growth factor receptor inhibitors EGFRL858R/T790M/C797S. One most promising compounds, 25g, inhibited enzymatic activity EGFRL858R/T790M/C797S with an IC50 value 2.2 nM. Cell proliferation assays showed that 25g effectively selectively EGFRL858R/T790M/C797S-dependent cells. This which occupy both ATP binding site allosteric EGFR kinase, may serve as basis for development fourth-generation...
Exosomes are essential mediators of intercellular communication as they transport proteins and RNAs between cells. Owing to their tumor-targeting capacity, immune compatibility, low toxicity, long half-life, mesenchymal stem cell-derived exosomes have great potential for the development novel antitumor strategies. In this context, role produced by adipose-derived cells (ADSCs) treatment bladder cancer (BC) remains unclear. Here, we investigated use ADSCs a source therapeutic exosomes, well...
Glioblastoma is the most common and deadly primary brain tumor in adults. Low-dose,metronomic (LDM) temozolomide (TMZ) displays improved efficacy treatment of glioblastoma by targeting angiogenesis, but has a limited effect on recurrence. The antiangiogenesis drug ginsenoside Rg3 (RG3) main active ingredient ginseng, popular herbal medicine. Using an vitro rat model orthotopic glioma allograft, this study was to determine whether RG3 enhanced activity LDM TMZ glioblastoma. Our results showed...
Abstract Numerous evidences have shown that circular RNAs (circRNAs) play a key role in regulating the pathogenesis of cancer. However, mechanism circRNAs urothelial carcinoma bladder (UCB) remains largely unclear. In this study, we found circFAM114A2 was significantly downregulated both UCB tissue specimens and cell lines, expression level highly correlated with pathological TNM stage grade. Functionally, overexpression dramatically inhibited migration, invasion proliferation cells vitro,...
With the wide clinical use of third-generation epidermal growth factor receptor (EGFR) inhibitor osimertinib for treatment EGFR-mutated non-small cell lung cancer (NSCLC), acquired resistance caused by EGFR C797S tertiary mutation has become a concern. Therefore, fourth-generation inhibitors that could overcome this have gained increasing attention in recent years. Here, we identified LS-106 as novel against and evaluated its antitumor activity both vitro vivo. In cell-free assay, potently...