A5040197406- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Infrared Thermography in Medicine
- Pancreatic and Hepatic Oncology Research
- Ultrasound and Hyperthermia Applications
- Ferroptosis and cancer prognosis
- Photoacoustic and Ultrasonic Imaging
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Cardiac Arrhythmias and Treatments
- Biochemical Acid Research Studies
- Gallbladder and Bile Duct Disorders
- Thermoregulation and physiological responses
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
Tianjin Medical University
2016-2025
Second Hospital of Tianjin Medical University
2016-2025
Chinese Academy of Sciences
2009-2025
Xinjiang Institute of Ecology and Geography
2025
University of Chinese Academy of Sciences
2025
Air Force Medical University
2025
Air Force General Hospital PLA
2008-2023
Qingdao University
2023
Affiliated Hospital of Qingdao University
2023
Shaanxi Normal University
2021-2022
Lung adenocarcinoma (LUAD) is the most common type of lung cancer which accounts for about 40% all cancers. Early detection, risk stratification and treatment are important improving outcomes LUAD. Recent studies have found that abnormal accumulation cystine other disulfide occurs in cell under glucose starvation, induces stress increases content bond actin cytoskeleton, resulting death, defined as disulfidptosis. Because study disulfidptosis its infancy, role disease progression still...
Net primary productivity (NPP) is a critical indicator for evaluating the carbon sequestration potential of an ecosystem and regional sustainable development, as its spatiotemporal dynamics are jointly influenced by natural anthropogenic factors. This study investigated Sangong River Basin, inland watershed located in northwestern China. By employing Carnegie–Ames–Stanford Approach (CASA) model Geodetector method, integrated with remote sensing data field surveys, we systematically analyzed...
A light-promoted Ni-catalyzed cyanation of aryl halides employing 1,4-dicyanobenzene as a cyanating agent is reported. broad array bromides, chlorides, and druglike molecules could be converted into their corresponding nitriles (65 examples). Mechanistic studies suggest that upon irradiation, the oxidative addition product Ni(II)(dtbbpy)(p-C6H4CN)(CN) undergoes homolytic cleavage Ni–aryl bond to generate an radical Ni(I)–CN species, latter which initiates subsequent reactions.
MicroRNA (miR)-21 is overexpressed in numerous types of malignancy and participates the development cancer. However, basic mechanism influence miR-21 on malignant phenotype pancreatic cancer remains unclear.The present study aimed to investigate role explore its molecular mechanism.The tissue samples were collected at Second Hospital Tianjin Medical University (Tianjin, China) between January 2013 December 2015. The expression VHL was evaluated by IHC staining. measured quantitative...
The change detection of urban buildings is currently a hotspot in the research area remote sensing, which plays vital role planning, disaster assessments and surface dynamic monitoring. SAR images have unique characteristics compared with traditional optical images, mainly including abundant image information large data volume. However, majority used for changes problems missing small poor edge segmentation. Therefore, this paper proposes new approach based on deep learning changing building...
In the filamentous fungus Aspergillus nidulans, both microtubules and actin filaments are important for polarized growth at hyphal tip. Less clear is how different microtubule-based actin-based motors work together to support this growth. Here we examined role of myosin-V (MYOV) in MYOV-depleted cells form elongated hyphae, but rate elongation significantly reduced. addition, although wild type without still undergo growth, microtubule disassembly abolishes cells. Thus, MYOV essential...
The taxonomic status of a methyl-parathion-degrading strain, OP-1 T , isolated from wastewater-treatment system in China, was determined using polyphasic approach. rod-shaped cells were Gram-staining-negative, non-spore-forming and non-motile. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the novel strain belonged to genus Burkholderia as it appeared closely related glathei ATCC 29195 (97.4 % sequence similarity), sordidicola KCTC 12081 (96.5 %) bryophila LMG 23644...
Background Spontaneous coronary artery dissection (SCAD) significantly contributes to myocardial infarction among young individuals. Despite the elusive nature of its etiology, empirical evidence indicates a substantial correlation between sociopsychological factors and disorder. This investigation endeavored discern genetic basis for personality traits influencing SCAD susceptibility. Methods Bidirectional univariate multivariate Mendelian randomization (MR) analyses were hereby conducted...
<title>Abstract</title> <bold>Background: </bold>Hypoxia and lactate metabolism products are critical components of the tumor microenvironment in pancreatic cancer (PC), influencing invasiveness, metastasis, treatment resistance. This study aims to explore role hypoxia- metabolism-related genes (HLRGs) predicting overall survival guiding for PC patients. <bold>Methods: </bold>Gene expression clinical data from patients were obtained TCGA, ICGC, GEO. Normal tissue sourced GTEx. Differential...
Due to the lack of specific symptoms, characteristic diagnostic markers and effective comprehensive treatment, gallbladder cancer (GBC) is currently considered one most malignant abdominal tumors. With rapid development biological technologies, long non‑coding RNAs (lncRNAs), once regarded as transcriptional junk, have been demonstrated participate in almost whole process central dogma molecular biology. The deals with transfer sequential information at level individual residues. LncRNAs an...
Sex and age show a dimorphism role in the pathogenesis, lymph node metastasis, prognostic outcomes of papillary thyroid carcinoma. This investigation endeavors to elucidate mechanisms underlying these disparities.
Abstract Liver cancer is the most common and epitome of a recalcitrant cancer. Increasing evidence shown that long noncoding RNAs (lncRNA) were associated with cancer‐related death could function as competing endogenous RNA (ceRNA). To explore regulatory roles potential prognostic biomarkers lncRNA for liver cancer, RNA‐sequencing expression data downloaded from TCGA database GEO database. A total 357 patients randomly divided into discovery group validation group, which 313 can obtain...
Abstract Background Due to their inherent role in cell function, long non‐coding ribonucleic acids (lncRNAs) mediate changes the microenvironment, and thereby participate development of cellular senescence. Aims This study aimed identify senescence‐related lncRNAs that could predict prognosis liver cancer. Methods Results Gene expression clinical data were downloaded from UCSC Xena platform, ICGC, TCGA databases. Cox regression LASSO used establish a lncRNA model. ROC curves Kaplan–Meier...
Thyroid papillary carcinoma (PTC) had a high possibility of recurrence after surgery, and thyroid stimulating hormone (TSH) suppression radioactive iodine (
Hepatocellular carcinoma (HCC) remains one of the most common human cancers, death cases induced by HCC are increasing these years. Endoplasmic reticulum stress (ERS) occurs when misfolded proteins cannot be disposed properly. It is reported that ERS plays a crucial role in pathogenesis malignant tumors. The aim this study to construct novel gene signature based on for predicting prognosis HCC.