A5068552713- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Photosynthetic Processes and Mechanisms
- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- Crop Yield and Soil Fertility
- Cancer-related molecular mechanisms research
- Plant Reproductive Biology
- Proteins in Food Systems
- Spinal Fractures and Fixation Techniques
- Seaweed-derived Bioactive Compounds
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cervical and Thoracic Myelopathy
- RNA modifications and cancer
- Medical Imaging and Analysis
- Plant nutrient uptake and metabolism
- Seed Germination and Physiology
- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Plant responses to water stress
- Pain Mechanisms and Treatments
- Plant Genetic and Mutation Studies
- Lipid metabolism and biosynthesis
Qingdao University
2014-2025
Affiliated Hospital of Qingdao University
2014-2025
Shenyang Jianzhu University
2025
Shandong University of Traditional Chinese Medicine
2024-2025
Frederick National Laboratory for Cancer Research
2024-2025
Henan Agricultural University
2015-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2012-2024
Ocean University of China
2009-2024
Leidos (United States)
2022-2024
Lung adenocarcinoma (LUAD) is the most common type of lung cancer which accounts for about 40% all cancers. Early detection, risk stratification and treatment are important improving outcomes LUAD. Recent studies have found that abnormal accumulation cystine other disulfide occurs in cell under glucose starvation, induces stress increases content bond actin cytoskeleton, resulting death, defined as disulfidptosis. Because study disulfidptosis its infancy, role disease progression still...
Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of cancer, and kinase α (CHKα), key enzyme for phosphatidylcholine production, overexpressed in many types human cancer through undefined mechanisms. Here, we demonstrate that the expression levels glycolytic enolase-1 (ENO1) are positively correlated with CHKα glioblastoma specimens ENO1 tightly governs via posttranslational regulation. Mechanistically, reveal both ubiquitin E3 ligase TRIM25 associated CHKα....
Low back pain (LBP) is one of the top three causes disability in developed countries, and intervertebral disc degeneration (IDD) a major contributor to LBP. In process IDD, there gradual decrease nucleus pulposus cells (NPCs) extracellular matrix (ECM). Exosomes are important exocrine mediators stem that can act directly on for tissue repair regeneration. this study, we determined antisenescence, cell proliferation promotion, ECM modulation effects human urine-derived (USC) exosomes...
Metabolic pathways fuel tumor progression and resistance to stress conditions including chemotherapeutic drugs, such as DNA damage response (DDR) inhibitors. Yet, significant gaps persist in how metabolic confer DDR inhibition cancer cells. Here, we employed a metabolism-focused CRISPR knockout screen identified genetic vulnerabilities We unveiled Peroxiredoxin 1 (PRDX1) synthetic lethality partner with Ataxia Telangiectasia Mutated (ATM) kinase. Tumor cells depleted of PRDX1 displayed...
Although seed vigor is a complex physiological trait controlled by quantitative loci, technological advances in the laboratory are being translated into applications for enhancing crop plants. In this article, we summarize and discuss pioneering work genetic modification of vigor, especially through over-expression protein L-isoaspartyl methyltransferase (PIMT, EC 2.1.1.77) seeds. The impressive success improving rice PIMT provides valuable reference engineering high-vigor seeds production....
Achieving grain supply security with limited arable land is a major challenge in the 21st century, owing to changing climate and increasing global population. Maize plays an increasingly vital role production. As C4 plant, maize has high yield potential. predicted become number one cereal world by 2020. However, production plateaued many countries, hybrid technologies have been fully exploited. Thus, there urgent need shape traits architectures for increased stress tolerance higher climate....
Homosapien collagen beta (1-O) galactosyl transferase 2 (COLGALT2) is an important enzyme during glycosylation, yet its biological functions in cancer are incompletely understood. Our previous study revealed that the osteosarcoma microenvironment, adipose-derived mesenchymal stem cells (ADSCs) demonstrate cancer-promoting effects, but exact mechanisms remain unclear. The aim of this was to investigate role COLGALT2 osteosarcoma-fostering effects ADSCs.
Abstract Background Frequently occurring drought stress negatively affects the production of maize worldwide. Numerous efforts have been made to develop drought-tolerant lines and explore tolerant mechanisms in maize. However, there is a lack comparative studies on transcriptomic changes between control lines. Results In present study, we developed mutant (C7–2t) by irradiating seeds inbred line ChangC7–2 (C7–2) with 60 Co-γ. Compared its wild type C7–2, C7–2t exhibited significantly delayed...
Objective. This study is aimed at determining the effects of human urine-derived stem cell-derived exosomes (USCs-exos) on pressure-induced nucleus pulposus cell (NPC) apoptosis and intervertebral disc degeneration (IDD) ERK AKT signaling pathways. Methods. The NPCs were obtained from patients with herniated lumbar discs. Western blot analysis (WB) quantitative real-time polymerase chain reaction (qRT-PCR) used to determine endoplasmic reticulum (ER) stress levels under stress. Human USCs...
Abstract Atherosclerosis is one of the leading causes death worldwide. miR-26 a potential biomarker atherosclerosis. Standardized diagnostic tests for (MIR26-DX) have been developed, but fastest progress has in predicting efficacy IFN-α therapy hepatocellular carcinoma (HCC, phase 3). MiR-26 slows atherosclerosis development by suppressing ACC1/2, ACLY, ACSL3/4, ALDH3A2, ALPL, BMP2, CD36, COL1A1, CPT1A, CTGF, DGAT2, EHHADH, FAS, FBP1, GATA4, GSK3β, G6PC, Gys2, HMGA1, HMGB1, LDLR, LIPC,...
The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid (GlcA), xylose (Xyl), and rhamnose (Rha). aim this study was detect immunomodulatory effects EP2 on RAW 264.7 macrophages cyclophosphamide (CYP)-induced immunosuppression mouse models. cells were treated with for different time periods (0, 0.5, 1, 3, 6 h). results showed that promoted nitric oxide production...
Abstract Drought-induced osmotic stress severely affects the growth and yield of maize. However, mechanisms underlying different responses young old maize leaves to remain unclear. To gain a systematic understanding age-related responses, we compared osmotic-stress-induced changes in ages using multi-omics approaches. After short-term stress, suffered more severe water deficits than leaves. The adjustments transcriptomes, proteomes, hormones response were dynamic Metabolic activities,...
To isolate a fucoidan-utilizing strain from seawater for sea cucumber fucoidan degradation.The utilization of was monitored by H(2)SO(4)-phenol assay neutral sugar. The bacterium CZ1127 isolated and shown to have relatively large maximum rate 81.5%. confirmed belong the family Flavobacteriaceae 16S rDNA physiological analyses. This has an ability utilize fucoidans extracted various cucumbers different degrees. Both extracellular intracellular enzymes could degrade fucoidan, as...
To better understand abscisic acid (ABA) regulation of the synthesis chloroplast proteins in maize (Zea mays L.) response to drought and light, we compared leaf proteome differences between ABA-deficient mutant vp5 corresponding wild-type Vp5 green etiolated seedlings exposed stress. Proteins extracted from leaves were used for two-dimensional electrophoresis (2-DE) subsequent matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). After Coomassie...
Osteosarcoma is the most common primary bone malignancy in children and young adults, but role of adipose-derived mesenchymal stem cells (ADSCs) rapid progression osteosarcoma still unclear. Here, we found that ADSCs promoted tumour growth invasion by increasing matrix metalloproteinase 2/9 (MMP2/9) expression cells. The persistent activation signal transducer activator transcription 3 (STAT3) has been shown to directly promote mediating a wide spectrum cellular responses, STAT3 was detected...