A5077556591- Musculoskeletal pain and rehabilitation
- Growth Hormone and Insulin-like Growth Factors
- Tendon Structure and Treatment
- Spine and Intervertebral Disc Pathology
Ludwig-Maximilians-Universität München
2004
Low back pain (LBP) is one of the top three causes disability in developed countries, and intervertebral disc degeneration (IDD) a major contributor to LBP. In process IDD, there gradual decrease nucleus pulposus cells (NPCs) extracellular matrix (ECM). Exosomes are important exocrine mediators stem that can act directly on for tissue repair regeneration. this study, we determined antisenescence, cell proliferation promotion, ECM modulation effects human urine-derived (USC) exosomes...
Numerous in vitro studies demonstrated that IGF-binding protein (IGFBP)-4 is a consistent inhibitor of IGF actions. In order to investigate the functions IGFBP-4 vivo, transgenic mice were generated by microinjection transgene, which murine Igfbp4 cDNA driven H-2Kb promoter. Transgene mRNA was expressed ubiquitously, and elevated detected spleen, thymus, kidney lung mice. Immunohistochemical showed transgene expression located predominantly thymic medulla red pulp spleen. Body weight not...