A5069558108- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Pelvic and Acetabular Injuries
- Medical Imaging and Analysis
- Musculoskeletal pain and rehabilitation
- Infectious Diseases and Tuberculosis
- Osteomyelitis and Bone Disorders Research
- Hip and Femur Fractures
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Anesthesia and Pain Management
- MicroRNA in disease regulation
- Spinal Cord Injury Research
- Spinal Dysraphism and Malformations
- Cancer-related molecular mechanisms research
- Spinal Hematomas and Complications
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Nerve Injury and Rehabilitation
- Hip disorders and treatments
- Nerve injury and regeneration
- Intraoperative Neuromonitoring and Anesthetic Effects
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
Yantai University
2025
Qingdao University
2016-2025
Affiliated Hospital of Qingdao University
2016-2025
Shaanxi Provincial People's Hospital
2024-2025
Shanxi Medical University
2025
Shaanxi Provincial People's Hospital
2025
Peking Union Medical College Hospital
2013-2016
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2016
Low back pain (LBP) is one of the top three causes disability in developed countries, and intervertebral disc degeneration (IDD) a major contributor to LBP. In process IDD, there gradual decrease nucleus pulposus cells (NPCs) extracellular matrix (ECM). Exosomes are important exocrine mediators stem that can act directly on for tissue repair regeneration. this study, we determined antisenescence, cell proliferation promotion, ECM modulation effects human urine-derived (USC) exosomes...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and devastating lung disorder. In response to transforming growth factor-β (TGF-β), normal cells proliferate differentiate into myofibroblasts, which are instrumental in promoting disease progression. Small interfering RNA (siRNA) targeting heat shock protein 47 (HSP47) has been demonstrated alleviate IPF by blocking collagen synthesis secretion. Exosomes (EXOs) have investigated for drug delivery due their superior carrier...
Monopolar electrocautery is usually a safe and effective technique used in laparoscopic cholecystectomy bile duct surgery, but it may lead to adverse consequences, even ventricular fibrillation (VF). Amiodarone an antiarrhythmic drug commonly practice treat atrial arrhythmias, induce tachyarrhythmia or VF. We report case of VF occurring twice during cholecystectomy. The first was caused by low-frequency leakage current the monopolar electrocautery. second due amiodarone causing further...
Transforming growth factor-β1 (TGF-β1) promotes the and metastasis of lung cancer cells. Therefore, TGF-β1 siRNA (siTGF-β1) gene therapy was introduced to inhibit expression at nucleic acid level avert tumor metastasis. However, delivery naked is typically restricted by a short half-life in vivo, difficulties safety issues. Using siTGF-β1 as model drug, we established an actively targeted immunoliposome system investigate role non-small-cell (NSCLC). The results showed that constructed...
To compare the outcomes and characteristics of oblique lumbar interbody fusion stand-alone (OLIF-SA) OLIF with posterior pedicle screw fixation (OLIF-PPS) in treatment Grade I or II degenerative spondylolisthesis.Between January 2019 May 2022, 139 patients spondylolisthesis were treated OLIF-SA (n = 85) OLIF-PPS 54). The clinical radiographic records reviewed.The similar both groups. operative time intraoperative blood loss group lower than those (P < 0.05). However, had significantly better...
There have been many reports on posterior hemivertebra resection. However, there were few articles in very young cases. This is a clinical retrospective study to evaluate the complications and efficacy of resection From January 2003 2012, 39 consecutive cases congenital scoliosis with retrospectively investigated our hospital, including 18 females 21 males, aged from 65 months old (average 42.4 months). All underwent transpedicular instrumentation. Clinical charts radiographs spine reviewed...
Abstract MicroRNAs (miRs) are short noncoding RNAs that play key regulatory roles in osteoblast differentiation. In this study, the specific of miR‐218‐5p on postmenopausal osteoporosis (PMOP) were investigated. The mouse model PMOP was established by bilateral ovariectomy, and injection mimics significantly relieved degree. Then, bone marrow mesenchymal stem cells (BMMSCs) isolated from mice induced into osteoblasts. When compared with normal BMMSCs , exhibited lower alkaline phosphatase...
To explore the risk factors related to perioperative neurocognitive disorders (PND) in elderly patients with hip fractures, acute pain management as core. This study used a retrospective case-control method. 90 who underwent artificial femoral head replacement or total surgery our hospital from 2022 2023 were collected, and divided into PND group non-PND based on occurrence of PND. Collected data 17 conducted univariate multivariate regression analysis analyze contribution value fractures....
The degeneration characteristics of adjacent segment disease are complex. Improper surgical planning has caused unnecessary trauma and costs. purpose this study was to establish a staging system for evaluate its guiding significance decisions in disease. A retrospective performed on 103 patients with who underwent treatment between January 2017 2023. Based radiological findings, categorized into four stages, no cases identified Stage IV. Patients were divided intervention groups: Group...
Study Design: Retrospective analysis of clinical efficacy. Objective: To assess the efficacy bilateral pedicle root puncture vertebral fissure expansion percutaneous kyphoplasty (PKP) in treatment Kümmell disease (KD). Summary Background Data: KD is a challenging condition characterized by delayed healing compression fracture, often leading to chronic pain and disability. Traditional treatments may not provide optimal outcomes, necessitating new interventional approaches. Methods: A...
Study Design. Retrospective analysis Objective. To develop a nomogram to predict the progression of ossification posterior longitudinal ligament (OPLL) after surgery, identify potential risk factors, and provide theoretical basis for preventing postoperative progression. Summary Background Data. OPLL is degenerative condition prevalent in Asian populations, leading spinal cord nerve root compression. While surgery primary treatment, progression, particularly surgeries, remains challenge,...
Retrospective study.To evaluate the clinical outcomes of hybrid technique 1-stage posterior osteotomy with short segmental fusion and dual growing rod (GR) for severe rigid congenital scoliosis.As some types scoliosis consist long curve including sharp deformities producing enormous asymmetric growth at apex, they cannot be well corrected fusion. GR may best option. However, potential due to apex will increase risk complications, especially implant failures.Seven patients (2 males, 5...
Objective Traditional manual OLIF combined with pedicle screw implantation has many problems of percutaneous implantation, such as high difficulty placement, fluoroscopies, long operation time, and adjustments, resulting in greater trauma. The robot can perform various types placement the lateral recumbent position, which allows posterior surgery to be completed a single position. To compare accuracy initial postoperative results oblique anterior lumbar fusion robot‐assisted position prone...
Retrospective study of instrumentation failure after posterior vertebral column resection (pVCR) in adult spinal deformity (ASD) patients.The morbidity and related risk factors the failure.Instrumentation is another common complication pVCR. But no report about it has been published before. The safety titanium mesh cages (TMCs) for this still unknown so far.A total 35 consecutive ASD patients (18 females 17 males), who underwent pVCR between May 2005 December 2014 our hospital, were...
Posterior hemivertebra resection has become a safe and effective procedure for congenital scoliosis due to hemivertebra. However, there are still complications following primary posterior in recent reports. No risk factors associated with construct/implant related were identified so far. The purpose of this study is analyze investigate the possible cases One hundred sixteen (male: female = 62:54), who underwent from January 2003 2012 our medical center, retrospectively evaluated study....
Posterior selective thoracolumbar or lumbar (TL/L) fusion with pedicle screw constructs for adolescent idiopathic scoliosis (AIS) has been studied in a few researches. However, studies have discussed the indication TL/L and behaviors of its adjacent disc angle. The present study aims to discuss posterior behavior angle.45 consecutive cases AIS undergoing were retrospectively evaluated, an average follow-up 36 months. Radiographs reviewed determine coronal curve magnitude sagittal alignment...
Retrospective study.
Various surgical techniques for treating spondylodiscitis have been proposed, but the optimal treatment remains controversial. In this study, we propose a new procedure that is implanting antibiotic-loaded calcium sulfate (CS) beads into disc after debridement using Quadrant channel combined with percutaneous fixation through single-stage posterolateral approach of spondylodiscitis. Thus, purpose study to assess safety and efficacy procedure. This collected data 32 patients spine was...
Adjacent segment disease (ASD) is a common complication following posterior disc decompression and fusion surgery. Percutaneous endoscopic lumbar surgery (PELD) has been used to treat ASD through either transforaminal or interlaminar approach. However, our limited knowledge there are no reports comparing the 2 approaches for treating ASD.To evaluate clinical outcomes of PELD in surgical results complications between approaches. This may be helpful spinal surgeons when decision-making...
Intraspinal gas pseudocyst is rare, especially following spinal surgery. Here we present a case of epidural lumbar decompression surgery, which caused dura sac compression.A 52-years-old woman with chronic pain and radiating numbness left leg was admitted to our hospital underwent posterior 10 days later, the patient began have dysfunction excretion. CT MRI were taken detected, compressed sac. A huge encapsulated high-tension air found during debridement no evidence infection.Debridement...