A5076936565- Natural Language Processing Techniques
- Topic Modeling
- Cancer, Hypoxia, and Metabolism
- Neural dynamics and brain function
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Click Chemistry and Applications
- Mitochondrial Function and Pathology
- Visual perception and processing mechanisms
- Cholesterol and Lipid Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Wound Healing and Treatments
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Microtubule and mitosis dynamics
- Peptidase Inhibition and Analysis
- Advanced Nanomaterials in Catalysis
- Cancer Immunotherapy and Biomarkers
- Neuroscience and Neuropharmacology Research
- Advanced Fluorescence Microscopy Techniques
- Biomedical Text Mining and Ontologies
- Glycosylation and Glycoproteins Research
- Magnetism in coordination complexes
- Speech Recognition and Synthesis
Sir Run Run Shaw Hospital
2011-2025
Zhejiang University
2011-2025
Affiliated Hospital of Qingdao University
2020-2025
Qingdao University
2020-2025
Binzhou University
2025
Suzhou University of Science and Technology
2025
Binzhou Medical University
2025
Center for Life Sciences
2017-2024
Zhuhai People's Hospital
2024
Guangdong Provincial People's Hospital
2024
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of β-catenin/TCF/LEF complex CD274 gene promoter region expression, which AKT activation plays an important role. β-Catenin depletion, inhibition, or PTEN expression reduces cells, enhances infiltration CD8+ T growth, accompanied prolonged mouse survival. Combined treatment with a clinically available inhibitor anti–PD-1 antibody overcomes greatly...
Aberrantly upregulated choline phospholipid metabolism is a novel emerging hallmark of cancer, and kinase α (CHKα), key enzyme for phosphatidylcholine production, overexpressed in many types human cancer through undefined mechanisms. Here, we demonstrate that the expression levels glycolytic enolase-1 (ENO1) are positively correlated with CHKα glioblastoma specimens ENO1 tightly governs via posttranslational regulation. Mechanistically, reveal both ubiquitin E3 ligase TRIM25 associated CHKα....
Abstract Seed number per unit area is important in determining yield soybean [ Glycine max (L.) Merr.]. Field and greenhouse experiments were conducted to evaluate the role of flowers plant flower fruit abscission pod seed numbers. Two with McCall cultivar [Maturity Group (MG) 00] four cultivars [McCall, Hardin (MG I), Harper III), Essex V)] used field 1989 1990. The either 0.38‐m (McCall Hardin) or 0.76‐m rows (Harper Essex) a constant seeding rate 26 seeds meter. Shade cloth (63% 30 63%...
Abstract Seeds per unit area is an important yield component in soybean [ Glycine max (L.) Merrill]; however, the mechanisms regulating seed number are not well understood. Field and greenhouse experiments were conducted to investigate relationship between photosynthesis during flowering podset seeds square meter. Shade cloth (30 63% reduction insolation) was used reduce from emergence Growth Stage R1 field ['Pennyrile' (indeterminate) 'Ripley' (determinate)] or for varying periods...
Abstract The integration of synaptic inputs onto dendrites provides the basis for neuronal computation. Whereas recent studies have begun to outline spatial organization on individual neurons, underlying principles related specific neural functions are not well understood. Here we perform two-photon dendritic imaging with a genetically-encoded glutamate sensor in awake monkeys, and map excitatory V1 superficial layer neurons high temporal resolution. We find functional trade-off between...