A5045560390- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Ginseng Biological Effects and Applications
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiomics and Machine Learning in Medical Imaging
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Effects of Radiation Exposure
- Fungal and yeast genetics research
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Enzyme Structure and Function
- Viral Infections and Immunology Research
- Medical Research and Treatments
- Postharvest Quality and Shelf Life Management
- RNA Research and Splicing
- Lung Cancer Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
- Medical Imaging and Pathology Studies
- Flavonoids in Medical Research
- Medical Image Segmentation Techniques
- Trace Elements in Health
China Agricultural University
2023-2025
East China University of Science and Technology
2023-2025
Shandong First Medical University
2025
Shandong Provincial Hospital
2025
Gansu Provincial Hospital
2019-2024
Second Affiliated Hospital of Zhejiang University
2017-2024
Peking University
2024
Beijing Jiaotong University
2023-2024
Center for Devices and Radiological Health
2023-2024
United States Food and Drug Administration
2023-2024
Cutin serves as the foundational structure of plant cuticle and plays a crucial role in determining fruit development quality. However, transcriptional regulation cutin deposition by fruit-specific transcription factors remains largely unknown. This study delves into regulatory tomato (Solanum lycopersicum) SBP-box protein Colorless Non-ripening (SlCNR), primarily expressed fruits, formation. We found that CRISPR/Cas9-induced slcnr mutants exhibited thicker cuticles elevated contents total...
Sepsis is a systemic inflammatory response to infection, where sepsis-associated acute kidney injury (AKI) common morbid disease with high morbidity and mortality, however at present no effective therapy exists. Increasing evidence have shown that mitochondrial damage are important initiating factors in pathogenesis of septic AKI. Natural flavonoid pectolinarigenin exerted anti-inflammatory properties previous studies, while its role AKI remains unknown. In the study, administration...
The potential for infection by coronaviruses (CoVs) has become a serious concern with the recent emergence of Middle East respiratory syndrome and severe acute (SARS) in human population. CoVs encode two large polyproteins, which are then processed into 15-16 nonstructural proteins (nsps) that make significant contributions to viral replication transcription assembling RNA replicase complex. Among them, nsp9 plays an essential role forming homodimer binds single-stranded RNA. Thus,...
Objectives This study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats. Methods Wistar rats were randomly divided into control, model, dexamethasone-positive, GRg3 low-dose, medium-dose, and high-dose groups. The ARP rat model was established by a single 22-Gy irradiation 6 MV) X-rays. distribution function intestinal flora detected using 16S rRNA high-throughput sequencing, rectal tissue observed hematoxylin eosin...
Acute respiratory distress syndrome (ARDS) is an acute and diffuse pulmonary inflammation, characterized by severe hypoxic failure caused inflammatory tissue damage, which a common cause of failure. Currently, there no treatment available that can prevent or reverse the devastating effects these conditions. The purpose this study was to determine WRS on gut microbiota potential effect lung disease using staphylococcal enterotoxin B (SEB)-induced ARDS model. results showed could significantly...
Chloroquine diphosphate (CQ) was ingeniously used to take place of phosphate salt in traditional calcium coprecipitation method for pDNA transfection. With multiple roles CQ the novel Ca-CQ-pDNA complex including compaction and assistance lysosome escape, transfection efficiency significantly increased relative method. did not intercalate into DNA double helix as free did, which probably ascribed prior mixing with high concentration chloride. In order construct efficacious vector vivo gene...
Background Familial hypocalciuric hypercalcemia (FHH) is an autosomal dominant disorder and represents a rare cause of hypercalcemia. It stems from variants in the calcium-sensing receptor gene (CaSR), G-protein subunit alpha11 (GNA11), or adaptor-related protein complex 2 (AP2S1), among which CaSR are most prevalent. However, challenges current diagnosis FHH persist, owing to overlap clinical features with primary hyperparathyroidism (PHPT). Case presentation The three reported patients...
Coencapsulation liposomes are of interest to researchers because they maximize the synergistic effect loaded drugs. A combination regimen mitoxantrone (MTO) and prednisolone (PLP) has been ideal for tumor therapy. MTO PLP offer antitumor effects confirmed by several experiments in this research. The deduced mechanism is regulation Akt signaling pathway including targets p-Akt, p-GSK-3β, p-s6 ribosomal protein, p-AMPK reactivating PLP-induced apoptosis. liposome fusion method adopted create...
A series of epoxy vitrimers (EVs) with enhanced glass transition temperatures (Tgs) were synthesized by curing resin E51 different ratios phthalic anhydride and sebacic acid as agents, 1,5,7-triazabicyclic [4.4.0] dece-5-ene a transesterification catalyst, their dynamics, rheological properties, mechanical thermal stability comprehensively investigated. By adjusting the molar ratio to carboxylic in agent, Tgs EVs increased from 79 143 °C increase content. In particular, material EV-5.5 high...
Abstract Background Myopia is a major health issue around the world. in children has increased significantly during COVID-19 pandemic China, but reports are scarce on prevalence of myopia following pandemic. This study collected vision screening data school China for five consecutive years to observe changes after and compare observed before Methods A school-based used stratified samplings collect aged 6–13 from 45 primary schools Hangzhou. Vision including uncorrected visual acuity(UCVA)...
Fruits of tomato (Solanum lycopersicum) are rich in nutrients and generally served as critical resources for human diet. In fruit pericarps, the peel tissues adhering to flesh produce functional components including flavonoids that indeed mixed polyphenolic compounds. Flavonoids play an essential role determining colour proven be functionally important health favourable hydrophilic antioxidants (Ballester et al., 2010). However, content endogenous numerous fruits tends inadequate fails meet...
Liver cancer, one of the most common malignant tumors, has seriously threatened people's physical and mental health. The paper was conducted to investigate functions two different anesthesia methods on Tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) T lymphocyte subsets in patients undergoing liver cancer resection, explore function impact surgery. 80 were split into propofol intravenous group sevoflurane inhalation group. patient's operation-related indicators changes TNF-α, CRP...
In 2020, Novartis Pharmaceuticals Corporation and the U.S. Food Drug Administration (FDA) started a 4-year scientific collaboration to approach complex new data modalities advanced analytics. The question was find novel radio-genomics-based prognostic predictive factors for HR+/HER- metastatic breast cancer under Research Collaboration Agreement. This has been providing valuable insights help successfully implement future projects, particularly using artificial intelligence machine learning....