A5100743213- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Galectins and Cancer Biology
- Gastroesophageal reflux and treatments
- Gut microbiota and health
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Appendicitis Diagnosis and Management
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Lipid metabolism and disorders
- RNA modifications and cancer
- Hedgehog Signaling Pathway Studies
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
First Affiliated Hospital of Nanchang University
2016-2025
Nanchang University
2016-2025
First Affiliated Hospital of Jiangxi Medical College
2024-2025
Bridge University
2024
Jiangxi Chest Hospital
2022-2023
National Natural Science Foundation of China
2020
Weatherford College
2020
Tufts University
2018
Veterans Health Administration
2016-2017
Beijing Sport University
2017
OBJECTIVES: To investigate the potential risk factors for endoscopic retrograde cholangiopancreatography (ERCP) complications and to identify whether are different pancreatitis asymptomatic hyperamylasemia. METHODS: Consecutive ERCP procedures were studied at 14 centers in China from May 2006 April 2007. The after patients' first-only evaluated. Multivariate analysis based on was used factors. RESULTS: A total of 3,178 performed 2,691 patients. Overall, developed 213 (7.92%) patients, 116...
Abstract All-trans retinoic acid inhibits inflammatory responses of human ulcerative and murine colitis. IBD is characterized by uncontrolled immune in inflamed mucosa, with dominance IL-17-producing cells deficiency Treg cells. The aim this study was to explore the effect mechanisms RA, ligand RARα, on Colonic biopsies from patients UC were cultured treated RA as agonist RARα or LE135 antagonist RARα. Expressions IL-17 FOXP3 detected immunohistochemistry. Murine colitis induced intrarectal...
Accumulating evidence suggests that high-fat diet (HFD) induced metabolic disorders are associated with dysbiosis of gut microbiota. However, no study has explored the effect HFD on gastric This established animal model to determine impact microbiota and its relationship alterations A total 40 male C57BL/6 mice were randomly allocated receive a standard chow (CD) or for 12 weeks (12CD group 12HFD group) 24 (24CD 24HFD (n = 10 per group). Body weight length measured Lee's index was calculated...
Early dysbiosis of the gut microbiota is associated with severity acute pancreatitis (AP), although underlying mechanism unclear. Here, we investigated role crosstalk between NLRP3 and in development AP utilizing deficient mice, as well knockout (KO) mouse models. Pancreatic damage systemic inflammation were improved antibiotic-treated (Abx) germ-free (GF) accompanied by weakened activity intestinal inflammasome. Interestingly, fecal transplantation (FMT) reactivated inflammasome exacerbated...
Helicobacter pylori (H. pylori) delivers oncoprotein CagA into gastric epithelial cells via the T4SS and drives activation of multiple oncogenic signalling pathways. YAP, a core effector Hippo tumour suppressor pathway, is frequently overexpressed in human cancers, suggesting its potential tumor-promoting role. Although casual factor H. induced carcinogenesis, link between YAP pathway has not been identified. In this work, we investigated regulation by CagA.Expression E-cadherin protein...
Background . H. pylori infection induces reactive oxygen species‐ (ROS‐) related DNA damage and activates the PI3K/Akt pathway in gastric epithelial cells. N ‐Acetylcysteine (NAC) is known as an inhibitor of ROS; role NAC ‐related diseases unclear. Aim The aim this study was to evaluate ROS protective pathogenesis diseases. Method An vitro coculture system vivo Balb/c mouse model ‐infected cells were established. effects on assessed by comet assay fluorescent dichlorofluorescein assay. level...
The eradication of Helicobacter pylori (H pylori) has been suggested to reduce the risk gastric cancer, but its impact on gut microbiota attracted public attention. This study aimed investigate short-term and long-term effects bismuth quadruple therapy both fecal microbiota.Ten asymptomatic young adults with H pylori-related gastritis were treated for 14 days, 7 age-matched without infection enrolled as healthy controls. Both mucosa samples collected from pylori-positive patients at weeks 0,...
Abstract Background Vonoprazan‐amoxicillin (VA) dual therapy has been shown to achieve acceptable cure rates for treatment of Helicobacter pylori ( H. ) in Japan. Its effectiveness other regions is unknown. We aimed explore the efficacy VA as first‐line infection China. Methods This was a single center, prospective, randomized clinical pilot study conducted Treatment naive infected patients were receive either low‐ or high‐dose amoxicillin‐vonoprazan consisting amoxicillin 1 g b.i.d. t.i.d...
H. pylori infection is the strongest known risk factor for gastric carcinoma. The activation of yes-associated protein 1 (YAP) and β-catenin pathways has been associated with multiple tumor types. In this study, we investigated crosstalk between YAP in pylori-associated tumorigenesis. Immunohistochemical analysis expression was performed human cancer tissues. small molecules Super-TDU KYA1797K, pharmacological inhibitors β-catenin, respectively, were used to investigate role these signaling...
Colorectal cancer (CRC)is the third most common in world and second leading cause of cancer-related deaths, over past two decades, many these researchers have provided a substantial amount important information on role gut microbes development progression CRC. A causal relationship between presence specific microorganisms CRC has also been validated. Although large number papers related to this area published, no bibliometric study conducted review current state research highlight trends...
Background and aim We previously reported that vonoprazan-amoxicillin (VA) dual therapy for 7 or 10 days is not satisfactorily efficacious Helicobacter pylori ( H. ) eradication. aimed to explore the efficacy of VA 14 as a first-line treatment infection. Methods This was single center, prospective, open-labeled, randomized non-inferiority clinical study conducted in China. Treatment naïve infected patients were into two groups: 20 mg vonoprazan (VPZ) b.i.d. combination with low-dose (1000...
Helicobacter pylori (H. pylori) infection is the main risk for gastric cancer (GC). However, cellular heterogeneity and underlying molecular mechanisms in H. pylori-driven tumorigenesis are poorly understood.