A5026751935- Amino Acid Enzymes and Metabolism
- Sulfur Compounds in Biology
- Chemokine receptors and signaling
- Ectopic Pregnancy Diagnosis and Management
- Neuroendocrine Tumor Research Advances
- Endometrial and Cervical Cancer Treatments
- Neuroblastoma Research and Treatments
- Folate and B Vitamins Research
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Reproductive Health and Contraception
- Cell Adhesion Molecules Research
- Multiple and Secondary Primary Cancers
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- Advanced Breast Cancer Therapies
- Glutathione Transferases and Polymorphisms
- Erythrocyte Function and Pathophysiology
- Immune cells in cancer
- Cervical Cancer and HPV Research
- Metabolomics and Mass Spectrometry Studies
Air Force Medical University
2013-2025
Xijing Hospital
2014-2025
Gansu University of Traditional Chinese Medicine
2023
Shougang (China)
2012
West China Second University Hospital of Sichuan University
2010-2011
Sichuan University
2010-2011
Harbor–UCLA Medical Center
2002
UCLA Medical Center
2002
University of Southern California
1992-1993
Great progress has been made in the field of tumor immunotherapy past decade. However, therapeutic effects immune checkpoint blockade (ICB) against ovarian cancer are still limited. Recently, an inhibitor cyclin-dependent kinases 4 and 6 (CDK4/6i) reported to enhance antitumor immunity preclinical models. The combined use CDK4/6i ICB may be beneficial, but CDK4/6is on microenvironment whether they can synergize with treating remain unknown. Methods: In this study, we first assessed efficacy...
Immune checkpoint inhibitors, such as anti-PD-1/PD-L1, are a novel class of inhibitors that function tumor suppressing factor via modulation immune cell-tumor cell interaction. To date, PD-1/PD-L1 have been approved for the treatment specific types tumors and obtained good clinical efficacy. However, patients with osteosarcoma showed poor response to anti-PD-1/PD-L1 therapy, mechanism which is not well understood. In this study, we found tissues were heavily infiltrated by myeloid-derived...
Nuclear factor of activated T-cells 5 (NFAT5) is recognized as an oncogene in a variety tumors. However, the role NFAT5 cervical cancer (CC) cell phenotypic alterations remains to be elucidated. Here, we demonstrated that expression was elevated CC samples and cells using quantitative real-time reverse transcription PCR, Western blot analysis, immunohistochemistry assays, high showed poor prognosis. After C-33A were transfected with pcDNA-NFAT5 or NFAT5-short hairpin RNA (shRNA),...
We reported that glucagon and phenylephrine decrease hepatocyte GSH by inhibiting gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in synthesis (Lu, S.C., J. Kuhlenkamp, C. Garcia-Ruiz, N. Kaplowitz. 1991. Clin. Invest. 88:260-269). In contrast, we have found insulin (In, 1 microgram/ml) hydrocortisone (HC, 50 nM) increased of cultured hepatocytes up to 50-70% (earliest significant change at 6 h) with either methionine or cystine alone as sole sulfur amino acid medium. The...
Ovarian cancer is an aggressive gynecological malignancy with high metastatic potential. Recently, the CXC receptor (CXCR7) has been identified as a new for stromal-derived factor-1 (SDF-1), and exerts important roles in development. However, its effect on ovarian underlying mechanism remain unknown. In this study, we detected abundant CXCR7 expression tissues cells. Moreover, SDF-1 induced dramatically upregulation of mRNA protein levels, indicating that SDF-1/CXCR7 axis existed cancer....
Primary cultures of adult rat hepatocytes shift into the growth phase when plated at low density (LD). We used this model to examine changes in glutathione (GSH) metabolism, since cells undergoing active may be more susceptible environmental toxins. When primary were on collagen or Matrigel-precoated dishes, cell number and GSH varied inversely. This effect occurred as early 2 h after plating, media contained 1 mM methionine, but was delayed until 20 if only 0.5 cystine. The synthesis...
In cultured rat hepatocytes, cystine led to an inhibition of GSH efflux by lowering the Vmax approximately 35% without affecting Km. The cystine-mediated was rapid in onset (< 1 h), with near maximum effect at 0.1 mM. Inhibition still observed when uptake prevented. Cystine and sulfobromophthalein-GSH, a selective inhibitor sinusoidal transport GSH, did not exhibit additive inhibitory effects on efflux. Depletion ATP or membrane depolarization after treatment were excluded as potential...
In rats the sinusoidal glutathione (GSH) carrier transports GSH bidirectionally, and its activity is influenced by thiol-disulfide status; Vmax of efflux was increased dithiothreitol (DTT) decreased cystine. present work we examined specificity directionality thiol effect. Using in situ perfused livers, found that 1 mM DTT other dithiols, including 1,2-ethanedithiol, 1,3-propanedithiol, 1,4-butanedithiol, stimulated 200-500% but dihydrothioctic acid, which negatively charged, had no...
Abstract Objective To evaluate the prognostic factors and survival outcome of patients with surgically treated high-grade neuroendocrine carcinoma cervix (NECC). Methods It was a multi-center, retrospective study that involved 98 cervical cancer stage IA2-IIIC NECC. We divided them into two groups based on histology: pure group mixed group. All clinicopathological variables were evaluated retrospectively. Cox regression Kaplan-Meier methods used for analysis. Results In our study, 60 in 38...
Abstract Objective To evaluate the prognostic factors and survival outcomes of patients with surgically treated high‐grade neuroendocrine carcinoma cervix (NECC). Methods This multicenter, retrospective study involved 98 cervical cancer stage IA2–IIA2 IIIC1/2p NECC. We divided into two groups based on histology: pure mixed groups. All clinicopathologic variables were retrospectively evaluated. Cox regression Kaplan–Meier methods used for analysis. Results In our study, 60 in group 38 group....
Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that mRNA protein levels were significantly upregulated EOC tissues compared normal tissues. High worse clinicopathological characteristics poor prognosis patients. Overexpression silencing promoted inhibited, respectively, invasion metastasis cells vitro vivo. Mechanistically,...
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In recent years, the majority women who have experienced artificial abortion (surgical and drug abortion) no children, they will to face procreative problem. Studies suggest that history of is not only directly related premature delivery in a subsequent pregnancy, but also closely concerned with threatened abortion, placenta previa, rupture membranes, fetal distress other complications during period next although it still controversial. This paper discusses effect on preterm labor pregnancy...
Objective To explore the effectiveness of uterine packing in controlling intractable hemorrhage during cesarean section with central placenta previa. Methods This retrospective study was conducted on clinical data 70 pregnant women who were diagnosed previa from May 2005 to March 2010, and has been used cases massive section. Causes hemorrhage, indication packing, procedure analyzed, volume bleeding compared. Informed consent obtained all participates. Results All successfully...
Ethnopharmacologicalrelevance: Codonopsis pilosula aqueous extract (CPAE), a traditional Chinese medicine, had been used to regulate the immune, digestive and circulatory systems of human, as well protect gastrointestinal tract, improve lung function.Aim study: The aim study was explore effects mechanism (CPAE) intervention in improving ulcerative colitis (UC).Materials methods: UC model rats were established using 5% dextran sulfate sodium (DSS). Tissue specimens sequenced by transcriptome...