Yuanyuan He

ORCID: 0000-0003-1804-0302
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Research Areas
  • Cardiovascular Health and Disease Prevention
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Viral Infections and Vectors
  • Neonatal Health and Biochemistry
  • Lipoproteins and Cardiovascular Health
  • Cardiovascular Disease and Adiposity
  • Diabetes Treatment and Management
  • Blood groups and transfusion
  • Cardiovascular Function and Risk Factors
  • Cerebrovascular and Carotid Artery Diseases
  • Cardiovascular, Neuropeptides, and Oxidative Stress Research
  • Cancer, Lipids, and Metabolism
  • Hemoglobinopathies and Related Disorders
  • Thyroid Disorders and Treatments
  • Traditional Chinese Medicine Analysis
  • Adipokines, Inflammation, and Metabolic Diseases
  • Soybean genetics and cultivation
  • Cytomegalovirus and herpesvirus research
  • COVID-19 Clinical Research Studies
  • Atherosclerosis and Cardiovascular Diseases
  • Agronomic Practices and Intercropping Systems
  • Health Systems, Economic Evaluations, Quality of Life
  • Multiple and Secondary Primary Cancers

Tianjin University of Traditional Chinese Medicine
2021-2025

Sichuan Agricultural University
2021-2025

Ministry of Agriculture and Rural Affairs
2024-2025

Lishui City People's Hospital
2025

Xijing Hospital
2024

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2021-2024

University of Electronic Science and Technology of China
2021-2024

Air Force Medical University
2024

The First People's Hospital of Shunde
2024

Guangdong Medical College
2024

Abstract Background The triglyceride glucose (TyG) index serves as a surrogate indicator of insulin resistance. However, there is limited evidence on the association between TyG and carotid artery plaque (CAP) in patients with coronary heart disease (CHD). Methods 10,535 CHD were divided according to quartiles (Q1: < 8.52; Q2: 8.52 ≤ 8.93; Q3: 8.93 9.40; Q4: > 9.40). presence or absence CAP was determined by ultrasonography. Logistic regression used analyze relationship patients. sex,...

10.1186/s12933-022-01470-3 article EN cc-by Cardiovascular Diabetology 2022-03-11

Red cell distribution width/albumin ratio (RAR) is thought to be associated with the prognosis of a variety diseases, including diabetes and heart failure. To date, no studies have focused on relationship between RAR carotid plaque in patients coronary disease (CHD).A total 10,267 CHD were divided according quartiles (Q1: ≤ 2.960; Q2: 2.960 < 3.185; Q3: 3.185 3.441; Q4: ≥ 3.441). Logistic regression was used analyze plaques patients. The sex, age glucose regulation state groups also...

10.1186/s12933-023-01768-w article EN cc-by Cardiovascular Diabetology 2023-02-22

Abstract Objective: This study aimed to explore the effects of Chinese patent medicine (CPM) in reducing incidence major adverse cardiovascular events (MACE) patients with coronary heart disease (CHD) angina pectoris and improving clinical effectiveness provide evidence for its use as adjuvant therapy. Methods: Twenty-eight thousand five hundred seventeen hospitalized CHD from 6 hospitals were divided into CPM group ( n = 11,374) non-CPM 17,143) evaluate MACE, including myocardial...

10.1097/hm9.0000000000000028 article EN cc-by-nc-nd Acupuncture and Herbal Medicine 2022-06-01

Context Thyroid hormones influence glucose homeostasis through central and peripheral regulation. To date, the association between thyroid hormone sensitivity elevated blood (EBG) in patients with coronary heart disease (CHD) remains unknown. The purpose of this study was to investigate risk EBG CHD, further explore their different sexes ages. Methods This large multicenter retrospective included 30,244 CHD (aged 30–80 years) 1 January 2014 30 September 2020. Parameters representing were...

10.3389/fendo.2022.895843 article EN cc-by Frontiers in Endocrinology 2022-06-15

Despite the notable advancements of existing prompting methods, such as In-Context Learning and Chain-of-Thought for Large Language Models (LLMs), they still face challenges related to various biases. Traditional debiasing methods primarily focus on model training stage, including approaches based data augmentation reweighting, yet struggle with complex biases inherent in LLMs. To address limitations, causal relationship behind is uncovered using a structural model, novel method front-door...

10.1609/aaai.v39i24.34777 article EN Proceedings of the AAAI Conference on Artificial Intelligence 2025-04-11

Purpose The METS-IR index, a non-insulin-based metabolic score, represents new marker closely linked to insulin resistance. This study aimed evaluate the relationship between index and dyslipidemia in individuals diagnosed with Cardiovascular disease (CVD), as well delve deeper into how varying glucose conditions influence this relationship. Methods multicenter retrospective investigation encompassed 214,717 CVD across China, spanning from September 1, 2014, June 2022, ultimately...

10.3389/fendo.2025.1473308 article EN cc-by Frontiers in Endocrinology 2025-05-12

Evidence on the relationship between low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and carotid plaques remains limited. This study aimed to examine association LDL-C/HDL-C in participants with coronary heart disease (CHD) further explore extent which a healthy lifestyle reduces risk of LDL-C/HDL-C-related plaques.

10.1186/s12944-021-01575-w article EN cc-by Lipids in Health and Disease 2021-10-27

Unlike other complications among very low birth weight infants (VLBW), the incidence of bronchopulmonary dysplasia (BPD) has not decreased substantially, partly because different definitions BPD applied by researchers. In this retrospective cohort study, we aimed to compare 2018 revised definition and 2001 consensus proposed National Institute Child Health Human Development (NICHD), as well identify which better predicts severe respiratory morbidities or death. We included 417 born at a...

10.3389/fped.2021.648972 article EN cc-by Frontiers in Pediatrics 2021-03-30

Long non-coding antisense RNAs in the INK4 locus (lnc-ANRIL) have been reported to be involved inflammation and immunity. However, few studies its clinical application pediatric inflammatory bowel disease (IBD). Therefore, we conducted this study investigate correlation between lnc-ANRIL expression risk, inflammation, activity IBD patients.Pediatric patients with Crohn's (CD; n = 40), ulcerative colitis (UC; controls (n 20) were recruited. For all patients, peripheral blood mononuclear cells...

10.1016/j.clinre.2022.101895 article EN cc-by-nc-nd Clinics and Research in Hepatology and Gastroenterology 2022-02-25

Mildew severely reduces soybean yield and quality, pods are the first line of defence against pathogens. Maize-soybean intercropping (MSI) mildew incidence on pods; however, mechanism remains unclear. Changing light (CL) from maize shading is most important environmental feature in MSI. We hypothesized that CL affects isoflavone accumulation pods, affecting their disease resistance. In present study, treatments were applied to plants during different developmental stages according various...

10.1111/pce.14128 article EN Plant Cell & Environment 2021-06-12

Gray leaf spot (GLS), caused by the fungal pathogen Cercospora zeina (C. zeina), is one of most destructive soil-borne diseases in maize (Zea mays L.), and severely reduces production Southwest China. However, mechanism resistance to GLS not clear few resistant alleles have been identified. Two inbred lines, which were shown be (R6) susceptible (S8) GLS, injected C. spore suspensions. Transcriptome analysis was carried out with tissue at 0, 6, 24, 144, 240 h after inoculation. Compared 0...

10.3390/plants10112257 article EN cc-by Plants 2021-10-22

MoS2 nanosheets (NSs) are novel 2D nanomaterials (NMs) being used in many important fields. Recently, we proposed the need to evaluate influences of NMs on Kruppel-like factors (KLFs) even if these materials relatively biocompatible. In this study, investigated NSs or bulk KLF4 signaling pathway 3D Caco-2 spheroids vitro and mouse intestines vivo. Through analysis our previous RNA-sequencing data, found that exposure activated expression spheroids. Consistently, also KLF4-related gene...

10.1002/tox.23819 article EN Environmental Toxicology 2023-04-26

Aerobic exercise has been shown to play a crucial role in preventing neurological diseases and improving cognitive function. In the present study, we investigated effect of treadmill training on retinal ganglion cells (RGCs) following optic nerve transection adult rats. We exercised rats for 5 d/week (30 min/d at rate 9 m/min) or placed control static treadmills. After 3 weeks exercise, left each rat was transected. surgery, another week. The percentages surviving RGCs axotomized eyes...

10.1016/j.exer.2020.108240 article EN cc-by-nc-nd Experimental Eye Research 2020-09-11
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