A5100461064- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- interferon and immune responses
- Gout, Hyperuricemia, Uric Acid
- Systemic Lupus Erythematosus Research
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- RNA modifications and cancer
- Viral Infections and Vectors
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Gastrointestinal Tumor Research and Treatment
- Curcumin's Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Inflammatory Myopathies and Dermatomyositis
- Mosquito-borne diseases and control
Xuzhou Medical College
2023-2025
Guangzhou University of Chinese Medicine
2018-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Peking Union Medical College Hospital
2022-2025
Jiangxi Maternal and Child Health Hospital
2022-2025
PLA Navy General Hospital
2025
Zhejiang University
2024
First Affiliated Hospital Zhejiang University
2019-2024
Academy of Military Medical Sciences
2022-2024
To analyze final long-term survival and clinical outcomes from the randomized phase III study of sunitinib in gastrointestinal stromal tumor patients after imatinib failure; to assess correlative angiogenesis biomarkers with patient outcomes.Blinded or placebo was given daily on a 4-week-on/2-week-off treatment schedule. Placebo-assigned could cross over at disease progression/study unblinding. Overall (OS) analyzed using conventional statistical methods rank-preserving structural failure...
Within the ongoing controversy regarding orogeny of Tibetan Plateau region, two directly conflicting endmember frameworks have emerged in which either: (1) a high central ‘proto-plateau’ existed before onset India–Asia continental collision; or (2) early Paleogene Tibet comprised wide east–west-oriented lowland c. 1–2 km above sea-level, bounded by (>4.5 km) mountain systems. Reconstructing development plateau correctly is fundamental to running realistic Earth system models that explore...
To present comprehensive information on the clinicopathological, molecular, survival characteristics, and quality of life (QOL) after surgery for solid pseudopapillary neoplasm (SPN) pancreas in a large cohort long-term follow-up.SPN is rare tumor with an uncertain malignant potential, prognosis QOL remains limited.All hospitalized patients SPNs who underwent between 2001 2021 at Peking Union Medical College Hospital were retrospectively reviewed. The clinicopathological characteristics...
Background The triglyceride and glucose (TyG) index has been found to be significantly associated with a higher risk of mortality. However, there lack studies exploring the specific relationship between TyG all-cause cardiovascular mortality among middle-aged elderly hypertension.
Objective. To explore the role of leonurine in regulation synovial inflammation and joint destruction inRA. Methods. Fibroblast-like synoviocytes were isolated from tissue RA patients. Pro-inflammatory cytokine MMP expression was evaluated using real-time PCR a cytometric bead array. Cell migration invasion vitro measured Boyden chamber method scratch assay, respectively. Protein by western blotting. Nuclear factor kappa B (NF-κB) nuclear translocation detected immunofluorescence. The vivo...
Acarose is an anti-diabetic drug and exhibited anti-arthritic effects. We hypothesized that acarbose influences the gut microbiota affects course of arthritis tested this hypothesis in collagen-induced (CIA). Acarbose drinking water was administered via gastric gavage started prior to or at time CIA induction. Fecal pellets were collected before induction, during onset after treatment for identification bacteria using16S rDNA sequencing. Changes T helper-17 (Th17) regulatory (Treg) cells...
The largest source of resistant bacteria or viruses is the overuse and misuse antibiotics in humans animals. These may evolve into superbacteria superviruses, which causes global plague. Therefore, it significant to find a highly efficiency low-cost method eliminate water environment from inappropriate discharge. Here, active stable heterogeneous catalyst, Cu0.76Co2.24O4/SBA-15 (CCS) was prepared for peroxymonosulfate (PMS) activation aim decomposing persistent sulfapyridine (SPD). reaction...
Background Currently, there is little literature about the association between physical activity (PA) and risk of ankylosing spondylitis (AS). The present study aimed to understand causal relationships PA AS. Methods We performed two-sample Mendelian randomization (MR) using publicly released genome-wide studies summary statistics estimate associations with AS risk. inverse variance weighted (IVW) method was utilized as primary MR analysis. Furthermore, sensitivity, pleiotropy, heterogeneity...
Neutrophils are major innate immune effector cells for host defense and have been a topic of active research their participation in the pathogenesis autoimmune inflammatory diseases including rheumatoid arthritis (RA) due to recently discovered neutrophil extracellular trap (NET) formation. NET formation other mechanisms leading release nuclear cytoplasmic contents implicated as source citrullinated antigens RA. Further investigations required delineate what factors diverge neutrophils from response
Abstract Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease characterized by pulmonary vascular remodeling, which may cause right heart failure even death. Accumulated evidence confirmed that microRNA‐26 family play critical roles in cardiovascular disease; however, their function PAH remains largely unknown. Here, we investigated the expression of miR‐26 plasma from patients using quantitative RT‐PCR, identified miR‐26a‐5p as most downregulated member, was...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Lupus nephritis (LN) common type of organ damage which occurs in SLE patients and characterized by recurrent proteinuria. Activation B lymphocytes can lead to refractory LN, an important pathogenic factor SLE. lymphocyte stimulator (BLyS) A proliferation-inducing ligand (APRIL) are predominantly produced myeloid cells (monocytes, dendritic cells, neutrophils, etc) regulate function. Telitacicept was the first dual-targeting...
Abstract After the termination of zero‐COVID‐19 policy, populace in China has experienced both Omicron BA.5 and XBB waves. Considering poor antibody responses severe outcomes observed among elderly following infection, we conducted a longitudinal investigation to examine epidemiological characteristics kinetics 107 boosted participants We that 96 (89.7%) were infected with BA.5, while 59 (55.1%) XBB. Notably, 52 (48.6%) dual infections The proportion symptomatic cases appeared decrease wave...