A5100676256- Respiratory viral infections research
- Influenza Virus Research Studies
- Data-Driven Disease Surveillance
- Tuberculosis Research and Epidemiology
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Animal Disease Management and Epidemiology
- COVID-19 and healthcare impacts
- Viral gastroenteritis research and epidemiology
- Berberine and alkaloids research
- Cancer Mechanisms and Therapy
- Climate Change and Health Impacts
- Dengue and Mosquito Control Research
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Animal Virus Infections Studies
- Emergency and Acute Care Studies
- Traditional Chinese Medicine Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Jiangmen Central Hospital
2024
Peking Union Medical College Hospital
2024
Chinese Center For Disease Control and Prevention
2007-2023
Jiangnan University
2019-2022
Dali University
2022
Wuxi No.2 People's Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
People’s University
2021
Center for Disease Control
2021
Using an elimination strategy, Hong Kong was able to minimise COVID-19 mortality in 2020 and 2021, but a large epidemic caused by the Omicron variant occurred 2022. We aimed estimate overall, age-, sex-, period- cause-specific excess 2022 compare laboratory-confirmed mortality. used negative binomial regression analysis model time series of weekly all-cause deaths from 2010 2021 predict number against counterfactual baselines projected trends absence pandemic. The estimated were compared...
Pulmonary tuberculosis (TB) caused by Mycobacterium is a chronic disease. Currently, there are no sufficiently validated biomarkers for early diagnosis of TB infection. In this study, panel potential serum was identified between patients with pulmonary and healthy controls using iTRAQ‐coupled 2D LC‐MS/MS technique. Among 100 differentially expressed proteins screened, 45 were upregulated (>1.25‐fold at p < 0.05) 55 downregulated (<0.8‐fold in the serum. Bioinformatics analysis...
Abstract Closure of live poultry markets was implemented in areas affected by the influenza virus A(H7N9) outbreak China during winter, 2013–14. Our analysis showed that closing most cities Guangdong and Zhejiang provinces highly effective reducing risk for H7N9 infection humans.
The epidemic of pulmonary tuberculosis (TB), especially multidrug-resistance (MDR-TB) presented a major challenge for TB treatment today.We performed iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) and Solexa sequencing among MDR-TB patients, drug-sensitive (DS-TB) healthy controls.A total 50 differentially expressed proteins 43 miRNAs (fold change >1.50 or <0.60, P<0.05) were identified in the patients compared to both DS-TB...
Rapid diagnosis of pulmonary tuberculosis is an effective measure to prevent the spread tuberculosis. However, grim fact that new, rapid, and safe methods for clinical are lacking. Moreover, although auto-lysosome critical in clearing Mycobacterium tuberculosis, pathological significance microRNAs, as biomarkers autophagosome maturation unclear. Here, these microRNAs were investigated by Solexa sequencing qPCR validation, a potential diagnostic model was established logistic regression....
At present, there are still many problems in the treatment of lung cancer, such as high cost, side effects and low quality life. The advantages traditional Chinese medicine (TCM) cancer reflected. Berberine has been increasingly popular colorectal treatment, but little is known about its bioactivity against non-small cell (NSCLC). Cell proliferation, apoptosis, cDNA microarray, gene protein expression, NSCLC transplanted tumour growth were performed. suppressed proliferation colony formation...
Abstract We investigated potential sources of infection for 6 confirmed influenza A (H5N1) patients who resided in urban areas People’s Republic China. None had known exposure to sick poultry or that died from illness, but all visited wet markets before illness.
Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or <0.60, P < 0.05). We validated albumin (ALB), Rho GDP-dissociation inhibitor 2 (ARHGDIB), complement 3 (C3), ficolin-2 (FCN2), apolipoprotein (a) (LPA) using enzyme-linked immunosorbent assay (ELISA)...
The aim of this study was to discover novel biomarkers for pulmonary tuberculosis (TB). Differentially expressed proteins in the serum patients with TB were screened and identified by iTRAQ-two dimensional liquid chromatography tandem mass spectrometry analysis. A total 79 abnormal discovered compared healthy controls. Of these, significant differences observed 47 abnormally between or pneumonia chronic obstructive disease (COPD). Patients (n = 136) exhibited significantly higher levels...
Evidence is inefficient about how meteorological factors influence the trends of influenza transmission in different regions China.We estimated time-varying reproduction number (Rt) and explored impact temperature relative humidity on Rt using generalized additive quasi-Poisson regression models combined with distribution lag non-linear model (DLNM). The effect interaction was explored. multiple random-meta analysis used to evaluate region-specific association. excess risk (ER) index defined...
Rationale: Nirmatrelvir/ritonavir is an effective drug for preventing the 2019 coronavirus disease epidemic from becoming a serious in adults. However, its efficacy pediatric cases remains unknown. This study aimed to analyze feasibility, safety, and of nirmatrelvir ritonavir treatment 6 14 year old children with severe acute respiratory syndrome type 2 (SARS-CoV-2) infection. Patient concerns: A child was admitted hospital disease, his worsened. Based on oxygen inhalation supportive...
Since March 2013, a novel influenza A(H7N9) virus has caused 3 epidemic waves of human infection in mainland China. We analyzed data from patients with laboratory-confirmed to estimate the risks for severe outcomes after hospitalization across waves. found that hospitalized confirmed infections 2 and were younger more likely be residing small cities rural areas than wave 1; they also had higher risk death, adjustment age underlying medical conditions. Risk death among during was lower...
Background: Berberine is one of the most interesting and promising natural anticancer drugs. POLE2 involved in many cellular functions such as DNA replication highly expressed a variety cancers. However, specific molecular mechanism berberine interfering with expression lung adenocarcinoma (LUAD) still unknown to great extent. Method: The KEGG database (Release 91.0) Gene Ontology (GO) category were used for functional annotation differentially genes after treatment. Reproducibility...
Abstract Background Mycobacterium tuberculosis infection can activate the immune system, leading to characteristic pathological changes such as inflammatory granuloma, caseous necrosis, and cavity formation. Methods Clinical data of 187 cases pulmonary (PTB) were analyzed using statistical methods, while serum levels complement C4b (C4b), fibronectin (FN), prolidase (PEPD) detected ELISA method among control, minimal PTB, moderate advanced PTB groups. Results We found significantly higher...
Abstract Objective To predict the trend of AIDS in specific age groups and to determine objective population for screening, this study explored three transmission routes characterized each patient group using APC model based on whole, local, immigrant populations Zhejiang, China. Methods The data recruited paper was obtained from national Comprehensive Prevention Control Information System - Antiviral Therapy Management database Chinese Disease Statistical Yearbook An used estimate impact...
ObjectiveWe aimed to review the development and changes of National Notifiable Disease Surveillance System (NNDSS) from 1950 2013, analyze summarize in regulations public health surveillance practices China.IntroductionInfectious disease was second most common cause death 1949, epidemic situation infectious diseases so severe that Chinese government made major investments control prevention diseases. During past 60 years notifiable system China has experienced 3 phases, including germination...
Objective: To retrospectively analyze if the use of topical intraoperative vancomycin powder reduces deep surgical site infection (DSSI) after posterior lumbar interbody fusion. Methods: All spinal surgeries for degenerative disease and underwent fixation fusion between January 2013 December 2018 were reviewed. A total 891 patients included, which 527 (treatment group) received intraoperatively powder; others served as control group. The primary outcomes overall incidence DSSI effect on its...
The global burden of respiratory diseases is a significant and increasing threat to individuals worldwide.In 2017, there were 544.9 million cases chronic diseases, 39.8% increase since 1990 (1).These the third leading cause mortality in accounting for 7.0% all deaths, an 18.0% compared 1990.In addition acute infectious including influenza, coronavirus 2019 (COVID-19), syncytial virus, pose public health concerns both short-term longterm damages (2-3).The presence complex coexisting system...