A5100394847- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Pneumonia and Respiratory Infections
- Metabolomics and Mass Spectrometry Studies
- Fungal Infections and Studies
- Fungal and yeast genetics research
- Cytokine Signaling Pathways and Interactions
- Multiple Myeloma Research and Treatments
- Diagnosis and treatment of tuberculosis
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- Complement system in diseases
- Liver Disease Diagnosis and Treatment
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Fungal Biology and Applications
- Chemokine receptors and signaling
- Synthesis and bioactivity of alkaloids
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Shanghai Municipal Center For Disease Control Prevention
2013-2025
First Affiliated Hospital Zhejiang University
2017-2024
Zhejiang University
2008-2022
Beijing Center for Disease Prevention and Control
2019-2022
Yue Bei People's Hospital
2020-2022
Shantou University Medical College
2022
Shantou University
2020-2022
Shaoguan University
2022
Qujiang People's Hospital
2022
Wuhan University
2022
Summary Candida albicans had been thought to lack a mating process until the recent discovery of type‐like locus and between MTL MTLα strains. To elucidate molecular mechanisms that regulate in C. , we examined function Cph1 its upstream mitogen‐activated protein (MAP) kinase pathway mating, as they are homologues pheromone‐responsive MAP Saccharomyces cerevisiae . We found overexpressing CPH1 but not /α strains, induced transcription orthologues S. pheromone‐induced genes also increased...
Clostridium difficile is a spore-forming, gram-positive, anaerobic bacillus that can cause C. infection (CDI). However, only few studies on the prevalence and antibiotic resistance of in healthy individuals China have been reported. We employed spore enrichment culture to screen for stool samples 3699 Chinese who were divided into 4 groups: infants younger than 2 years age living at home with their parents; children aged 1 8 attending three different kindergarten schools; community-dwelling...
Rapid diagnosis of pulmonary tuberculosis is an effective measure to prevent the spread tuberculosis. However, grim fact that new, rapid, and safe methods for clinical are lacking. Moreover, although auto-lysosome critical in clearing Mycobacterium tuberculosis, pathological significance microRNAs, as biomarkers autophagosome maturation unclear. Here, these microRNAs were investigated by Solexa sequencing qPCR validation, a potential diagnostic model was established logistic regression....
Currently, the management of pulmonary tuberculosis (TB) lacks potent medications and accurate efficacy evaluation biomarkers. In view fact that host lipids are important energy source Mycobacterium (Mtb), UPLC-MS/MS based on lipid metabolism was used to monitor plasma spectrum TB patients from initial diagnosis cured. The analysis showed presented aberrant phospholipids, glycerides, sphingolipids. Upon treatment, abnormal expression Cer (d18:1/24:0), CerP (d18:1/20:3), LPE (0:0/22:0), LPA...
An endophytic fungus, Mycosphaerella nawae ZJLQ129, was isolated from the leaves of traditional Chinese medicine Smilax china. From fermentation broth and mycelium, a dibenzofurane compound (-)mycousnine (1) isolated. Chemical modification it to amide derivative enamine (2), which is new science, found have high selective immunosuppressive activity: similar cyclosporin A, (2) selectively inhibited T cell proliferation, suppressed expression surface activation antigens CD25 CD69 formation...
Lack of laboratory standards for cured tuberculosis (TB) can lead to early discharge untreated TB patients from the hospital, resulting in increased risk spread and developing drug resistant Mycobacterium (Mtb). We used ultra-high performance liquid chromatography coupled with mass spectrometry (LC-MS) detect heparin anticoagulant plasma patients, two-month treated subjects, healthy controls. Screening differentially expressed metabolites resulted identification four such as, l-Histidine,...
Introduction Tuberculosis preventive treatment (TPT) has been initiated systematically in Shanghai supported by a public health project. This study aimed to evaluate the acceptance of TPT, identify factors related its refusal, and find an optimal way promote TPT among student tuberculosis (TB) contacts. Methods We screened contacts TB index case from outbreak on campus. A two-step approach first conducting lecture literacy, followed one-on-one consultations was used mobilise students with...
The PCR-based variable-number tandem repeats (VNTR) typing method is a very promising tool for the molecular epidemiological study of Mycobacterium tuberculosis. discriminatory power VNTR loci that were optimized in many previous studies has not been evaluated Shanghai, an area where Beijing genotype strains dominate. In present study, we first performed literature search to identify at least 45 bp length. Second, determined Hunter-Gaston index (HGI) values each identified, using from 'test...
With the development of novel therapeutic agents, survival multiple myeloma (MM) patients has much improved. However, disease is incurable due to drug resistance. Previous studies have found that high-mobility group box 1 (HMGB1) involved in inflammation, angiogenesis, DNA damage repair, and cancer invasion, progression, metastasis resistance high HMGB1 expression associated with poor MM prognosis, yet role mechanism remains unclear. Through gene Oncomine database analyses, we a prognosis...
Objectives: Fifteen years after the roll-out of antiretroviral treatment (ART) in China, there is limited information available on transmitted HIV drug resistance (TDR). This study aimed to characterize epidemiology TDR China. Design: We conducted a prospective cross-sectional observational study. Methods: analyzed demographic, clinical, and virological data individuals with newly diagnosed infection using from Beijing laboratory network collected between 2001 2017. did population-based...
Multiple myeloma (MM) is a malignant plasma disease closely associated with inflammation. In MM bone marrow microenvironment, stromal cells (BMSCs) are the primary source of interleukin-6 (IL-6) secretion, which promotes proliferation and progression cells. However, it still unknown how microenvironment stimulates BMSCs to secrete IL-6. Interleukin-32 (IL-32) newly identified pro-inflammatory factor. It was reported that in solid tumors, IL-32 induces changes other inflammatory factors...
Multidrug-resistant tuberculosis (MDR-TB), defined as (TB) resistant to at least isoniazid and rifampicin, is a major concern of TB control worldwide. However, the diagnosis MDR-TB remains huge challenge its prevention control. To identify new diagnostic methods for MDR-TB, mass spectrometry strategy data-independent acquisition parallel reaction monitoring was used detect validate differential serum proteins. The bioinformatic analysis showed that functions proteins between group...
Early diagnosis of active pulmonary tuberculosis (TB) is the key to controlling disease. Host lipids are nutrient sources for metabolism Mycobacterium tuberculosis. In this research work, we used ultra-high-performance liquid chromatography-tandem mass spectrometry screen plasma in TB patients, lung cancer community-acquired pneumonia and normal healthy controls. Principal component analysis, orthogonal partial least squares discriminant K-means clustering algorithm analysis were identify...
Saffron crocus (Crocus sativus) is an expensive and valuable species that presents preventive curative effects. This study aimed to screen the key proteins affecting floral initiation of saffron under cold stress thus increasing yield by regulating temperature.Protein expression profiles in flowering non-flowering buds were established using isobaric tags for relative or absolute quantitation (iTRAQ). A total 5,624 identified, 201 differentially abundant protein (DAPs) further obtained...
Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work conducted explore the molecular mechanism ZDG YDH syndrome, and processes prevention treatment have developed slowly. The present study was aimed therapeutic on syndrome. rats were induced by hot herbs, then treated orally 1 week. Body weight measured every 2 days. After sacrifice, blood samples collected thymus,...
Background The management of latent tuberculosis infection (LTBI) is a key action for the realization “End (TB) Strategy” worldwide, and it important to identify priority populations. In this prospective cohort study, we evaluated prevalence LTBI incidence active TB among close contacts explored suitable control strategy in schools. Methods We designed with 2 years follow-up, recruiting freshman/sophomore patients’ from three administrative districts Shanghai. These were chosen based on...
The lack of rapid and efficient diagnostics impedes largely the epidemic control multidrug-resistant tuberculosis, might misguide therapeutic strategies as well. This study aimed to identify novel tuberculosis biomarkers improve early intervention, symptomatic treatment prevalence tuberculosis. serum small molecule metabolites in healthy controls, patients with drug-susceptible were screened using ultra-high-performance liquid chromatography combined quadrupole-time-of-flight mass...