A5069504531- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Histone Deacetylase Inhibitors Research
- Cytokine Signaling Pathways and Interactions
- Fossil Insects in Amber
- Plant and animal studies
- Cancer Mechanisms and Therapy
- Biomedical Text Mining and Ontologies
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Chemokine receptors and signaling
- Natural Compounds in Disease Treatment
- Dental Radiography and Imaging
- RNA modifications and cancer
- Medicinal Plant Pharmacodynamics Research
- Machine Learning in Healthcare
- Quinazolinone synthesis and applications
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 and COVID-19 Research
- Indoor and Outdoor Localization Technologies
- Monoclonal and Polyclonal Antibodies Research
- Artificial Intelligence in Healthcare
Zhejiang University
2015-2024
First Affiliated Hospital Zhejiang University
2014-2024
Peking University
2016-2023
Georgia Institute of Technology
2023
Zhejiang Lab
2022
Stomatology Hospital
2020-2021
King University
2020-2021
National Clinical Research Center for Digestive Diseases
2020-2021
Northwest A&F University
2012-2013
Abstract N 6 -methyladenosine (m A), an internal modification in mRNA, plays a critical role regulating gene expression. Dysregulation of m A modifiers promotes oncogenesis through enzymatic functions that disrupt the balance between deposition and removal on transcripts. However, roles mRNA multiple myeloma (MM) are poorly understood. The present study showed RNA demethylase ALKBH5 was overexpressed MM associated with poor prognosis patients. Knocking down induced apoptosis inhibited growth...
Abstract We present the initial work toward developing a clinical decision support model for specific design of removable partial dentures (RPDs) in dentistry. developed an ontological paradigm to represent knowledge patient’s oral conditions and denture component parts. During case-based reasoning process, cosine similarity algorithm was applied calculate values between input patients standard ontology cases. A group designs from most similar cases were output as final results. To evaluate...
We previously showed that the chemokine CCL2 can recruit macrophages (Mφs) to bone marrow (BM) in multiple myeloma (MM) and myeloma-associated Mφs are important drug resistance. Here, we explore role of increased expression BM microenvironment MM elucidate underlying mechanism. Our results show is associated with treatment status patients. interact cells further upregulate their CCL2. These level polarizes toward M2-like phenotype promotes protect from drug-induced apoptosis....
// Donghua He 1, * , Xing Guo Enfan Zhang 1 Fuming Zi 2 Jing Chen Qingxiao Xuanru Lin Li Yang Yi Wenjun Wu Jingsong Zhen Cai Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Department Hematology, Second Hospital Nanchang Nanchang, Jiangxi, These authors contributed equally to this work Correspondence to: Cai, email: caiz@zju.edu.cn Keywords: apoptosis, dexamethasone, multiple myeloma, quercetin Received:...
Abstract Although various magnetic sensors have been developed, tiny object detection is still a challenging issue in some cases, such as capsule position detection, endoscope navigation, and the of devices hidden in/on human body. In this paper, detecting sketching system utilizing 1D sensor array with 56 magnetoelectric (ME) sensing units proposed. The ME used are based on (1‐1) connectivity Metglas/piezofiber composite operating longitudinally magnetized transversely poled (L‐T) mode....
E3 ubiquitin ligases primarily determine the substrate specificity of ubiquitin‐proteasome system and play an essential role in resistance to bortezomib multiple myeloma (MM). Neural precursor cell‐expressed developmentally downregulated gene 4‐1 (NEDD4‐1, also known as NEDD4) is a founding member NEDD4 family involved proliferation, migration, invasion drug sensitivity cancer cells. In present study, we investigated NEDD4‐1 MM cells explored its underlying mechanism. Clinically, low...
Bortezomib (bort) is an effective therapeutic agent for patients with multiple myeloma (MM); however, most develop drug resistance. Autophagy, a highly conserved process that recycles cytosol or entire organelles via lysosomal activity, essential the survival, homeostasis, and resistance in MM. Growing evidence has highlighted E3 ligase tripartite motif-containing protein 21 (TRIM21) not only interacts autophagy regulators but also participates various cancers. However, to date, direct...
With the development of novel therapeutic agents, survival multiple myeloma (MM) patients has much improved. However, disease is incurable due to drug resistance. Previous studies have found that high-mobility group box 1 (HMGB1) involved in inflammation, angiogenesis, DNA damage repair, and cancer invasion, progression, metastasis resistance high HMGB1 expression associated with poor MM prognosis, yet role mechanism remains unclear. Through gene Oncomine database analyses, we a prognosis...
Multiple myeloma (MM) is a malignant plasma disease closely associated with inflammation. In MM bone marrow microenvironment, stromal cells (BMSCs) are the primary source of interleukin-6 (IL-6) secretion, which promotes proliferation and progression cells. However, it still unknown how microenvironment stimulates BMSCs to secrete IL-6. Interleukin-32 (IL-32) newly identified pro-inflammatory factor. It was reported that in solid tumors, IL-32 induces changes other inflammatory factors...
Abstract We aimed to characterize the role of B-cell activating factor (BAFF) in macrophage-mediated resistance multiple myeloma (MM) cells bortezomib (bort), and further understand molecular mechanisms involved process. First, we detected BAFF its three receptors on macrophages using quantitative reverse transcriptase-polymerase chain reaction flow cytometry. The secretion was tested patients with MM, MM cell lines, macrophages. ability protect from bort-induced apoptosis significantly...
Histone deacetylases are promising therapeutic targets in hematological malignancies. In the work herein, we investigated effect of chidamide, a new subtype-selective histone deacetylase inhibitor that was independently produced China, on multiple myeloma and its associated bone diseases using different models. The cytotoxicity chidamide toward is due to induction cell apoptosis cycle arrest by increasing levels caspase family proteins p21 p27, among others. Furthermore, exhibited...
Abstract The evolutionary origin of holometabolous larvae is a long‐standing and controversial issue. Mecoptera are unique in Holometabola for their possessing pair compound eyes instead stemmata. ultrastructure the larval scorpionfly Panorpa dubia Chou Wang, 1981 was investigated using transmission electron microscopy. Each ommatidium possesses cornea, tetrapartite eucone crystalline cone, eight retinula cells, two primary pigment an undetermined number secondary cells. rhabdomeres cells...
Qualified diagrams of removable partial denture (RPD) designs created by dentists provide technicians with clear and dynamic information. Generating RPD design in the clinical decision support system (CDSS) can be achieved producing a textual format then transferring onto diagrams. The drawing automatically efficiently for given is still under investigation. A new workflow consisting three major steps developed to produce visualize two-dimensional Annotations orientations teeth are...
SWe explored the incidence of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections in 131 patients with multiple myeloma (MM), 53 whom received daratumumab (Dara) treatments. The Dara group had more RRMM than without Dara. CMV infection was significantly common treated (16.98%) regimens (2.56%). During treatments, 24.53% developed and/or EBV infections. Patients who lower levels albumin lymphocytes their peripheral blood. median time from first infusion to 27 days. We observed NK...
Abstract Background Comparative investigations evaluating the efficacy of pomalidomide‐based (Pom‐based) versus daratumumab‐based (Dara‐based) therapies in patients with relapsed/refractory multiple myeloma (RRMM) remain scarce, both randomized controlled trials and real‐world studies. Methods This retrospective cohort study included 140 RRMM treated Pom‐based or Dara‐based a combination pomalidomide daratumumab (DPd) regimens Chinese tertiary hospital between December 2018 July 2023....
Clinical success of the proteasome inhibitor established bortezomib as one most effective drugs in treatment multiple myeloma (MM). While survival benefit generated new strategies, primary and secondary resistance MM cells to remains a clinical concern. This study aimed highlight role p53-induced RING-H2 (Pirh2) acquisition clarify function mechanism action Pirh2 cell growth resistance, thereby providing basis for therapeutic targets MM. The has been treating We demonstrated that resulted...
Abstract Background Multiple myeloma (MM) is the second most common hematologic malignancy with almost all patients eventually having relapse or refractory MM (RRMM), thus novel drugs combination therapies are needed for improved prognosis. Chidamide and venetoclax, which target histone deacetylase BCL2, respectively, two promising agents treatment of RRMM. Results Herein, we found that chidamide venetoclax synergistically exert an anti-myeloma effect in vitro human cell lines (HMCLs) a...
Extracting information from unstructured clinical text is a fundamental and challenging task in medical informatics. Our study aims to construct natural language processing (NLP) workflow extract Chinese electronic dental records (EDRs) for decision support systems (CDSSs). We extracted attributes, attribute values, tooth positions based on an existing ontology EDRs. A integrating deep learning with keywords was constructed, which vectors representing texts were unsupervised learned....
Multiple myeloma is genetically heterogeneous, and chromosome abnormalities play a pivotal role in prognosis. A gain 1q (+1q) among the most common cytogenetic abnormalities; however, its relationship with overall survival (OS) progression-free (PFS) patients multiple still unclear. We aim to clarify impact of +1q on clinical characteristics outcomes treated bortezomib-based combination regimes. retrospectively analyzed 258 first diagnosed who underwent therapy at bone marrow transplantation...