A5100433054- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Liver Diseases and Immunity
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Pediatric Hepatobiliary Diseases and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Immune Response and Inflammation
- Cancer-related gene regulation
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Autoimmune Neurological Disorders and Treatments
First Affiliated Hospital of Jiangxi Medical College
2025
Jiangxi Provincial People's Hospital
2025
Peking University
2013-2025
Huashan Hospital
2014-2025
Yangzhou University
2025
Suzhou Municipal Hospital
2025
Nanjing Medical University
2016-2025
Lu'an First People's Hospital
2025
Anhui Medical University
2016-2025
Fudan University
2014-2025
Liver mass depends on one or more unidentified humoral signals that drive regeneration when liver functional capacity is diminished. Bile acids are important products, and their levels tightly regulated. Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal regeneration. Elevated accelerate regeneration, decreased inhibit regrowth, as does the absence of primary receptor FXR. We propose FXR activation by increased flux signal liver. FXR, possibly other...
Objective A close relationship between gut microbiota and some chronic liver disorders has recently been described. Herein, we systematically performed a comparative analysis of the microbiome in primary biliary cholangitis (PBC) healthy controls. Design We first conducted cross-sectional study 60 ursodeoxycholic acid (UDCA) treatment-naïve patients with PBC 80 matched Second, an independent cohort composed 19 34 controls was used to validate results. Finally, prospective subgroup 37 who...
Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator autoimmunity. aim this study was to take advantage large well-defined corticosteroids treatment-naïve group patients with autoimmune hepatitis (AIH) rigorously characterise gut dysbiosis compared healthy controls. Design We performed cross-sectional individuals AIH (n=91) and matched controls (n=98) by 16S rRNA gene sequencing. An independent cohort 28 34 analysed validate results....
The constitutive androstane receptor (CAR, NR1I3) is a central regulator of xenobiotic metabolism. CAR activation induces hepatic expression detoxification enzymes and transporters increases liver size. Here we show that CAR-mediated hepatomegaly transient, adaptive response to acute stress. In contrast, chronic results in hepatocarcinogenesis. both responses, hepatocyte DNA replication increased apoptosis decreased. These effects are absent null mice, which completely resistant tumorigenic...
As part of a large scale effort to discover novel secreted proteins, cDNA encoding cytokine was identified. Alignments the sequence new protein, designated IL-17B, suggest it be homolog recently described T cell-derived cytokine, IL-17. By Northern analysis, EST distribution and real-time quantitative polymerase chain reaction mRNA detected in many cell types. A type I transmembrane identified an data base by homology IL-17R, found bind specifically as determined surface plasmon resonance...
Abstract BACKGROUND Vascular endothelial growth factor (VEGF) is a critical proangiogenic in solid tumors. However, its expression and role human neuroendocrine tumor development progression remains unclear. METHODS Using immunohistochemistry, VEGF Sp1 patterns were investigated 50 cases of gastrointestinal having various clinicopathologic characteristics. RESULTS It was found that strong detected cells, whereas no or very weak stromal cells surrounding within the The levels directly...
Genetic mutation and pharmacological inhibition of Bruton9s tyrosine kinase (Btk) both have been shown to prevent the development collagen-induced arthritis (CIA) in mice, providing a rationale for Btk inhibitors treating rheumatoid (RA). In present study, we characterized novel inhibitor, 6-cyclopropyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(4-methyl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-2<i>H</i>-isoquinolin-1-one (RN486), vitro rodent models...
Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces. S1P enriched and stored in erythrocytes; however, it not clear whether alterations are involved the prevalent debilitating hemolytic disorder sickle disease (SCD). Here, using metabolomic screening, we found highly elevated blood of mice humans SCD. In murine models SCD, demonstrated erythrocyte sphingosine kinase 1 (SPHK1) underlies sickling...
Purpose: B-cell lymphoma-2 (BCL-2), an antiapoptotic protein often dysregulated in lymphomas, promotes cell survival and provides protection from stress. A recent phase I first-in-human study of the BCL-2 inhibitor venetoclax non-Hodgkin lymphoma showed overall response rate 44%. These promising clinical results prompted our examination biological effects mechanism action underlying activity aggressive lymphoma, including mantle (MCL) diffuse large (DLBCL).Experimental Design: MCL DLBCL...
Multiple clinical similarities exist between IgG4-related sclerosing cholangitis (IgG4-SC) and primary (PSC), while gut dysbiosis has been extensively studied in PSC, the role of microbiota IgG4-SC remains unknown. Herein, we aimed to evaluate alterations microbiome metabolome PSC.We performed 16S rRNA gene amplicon sequencing faecal samples from 135 subjects with (n=34), PSC (n=37) healthy controls (n=64). A subset (31 IgG4-SC, 37 45 controls) also underwent untargeted metabolomic...
Proximal spinal muscular atrophy (SMA), one of the most common genetic causes infant death, results from selective loss motor neurons in cord. SMA is a consequence low levels survival neuron (SMN) protein. In humans, SMN gene duplicated; SMN1 but SMN2 remains intact. severity related to copy number SMN2. Compounds which increase expression could, therefore, be potential therapeutics for SMA. Ultrahigh-throughput screening recently identified substituted quinazolines as potent inducers. A...
Multiple sclerosis (MS) is an irreversible and demyelinating disease of the central nervous system, in part influenced by chronic inflammation. There no proven effective therapy to stop pathological progression MS, although suppressing immune system control inflammatory response may improve clinical performance acutely. Here, we found that mesenchymal stem cells from human umbilical cord (hUC-MSCs) could restore behavioral functions attenuate histopathological deficits experimental...
The serologic hallmark of primary biliary cirrhosis (PBC), the antimitochondrial response to E2 component pyruvate dehydrogenase complex (PDC-E2), has unique features, including continuous high titers immunoglobulin M (IgM) and IgG reactivity throughout all stages disease, capable not only target enzyme inhibition, but also crossreactive with chemical xenobiotics that share molecular homology inner lipoyl domain PDC-E2; such chemicals have been proposed as potential etiological agents. We...
Summary Fedratinib, an oral Janus kinase‐2 (JAK2) inhibitor, reduces splenomegaly and improves symptom burden in patients with myelofibrosis. Regulatory approval of fedratinib 400‐mg daily was based on results updated analysis the pivotal phase III, placebo‐controlled JAKARTA trial JAK‐inhibitor‐naïve At week 24, spleen volume response rate 47% 40% 400 mg, versus 1% 9% respectively, placebo. Common adverse events were diarrhoea, nausea, anaemia, vomiting. No Wernicke encephalopathy occurred...
Background: Increasing data suggests an interaction between bile acids and intestinal microbiota in the pathogenesis of primary biliary cholangitis (PBC). Bile acid sequestrants are widely used to bind lumen therefore posited impact gut bacteria. Herein we aimed investigate effects cholestyramine on profile microbiome a cohort icteric PBC patients.Results: Thirty-three patients were treated with cholestyramine, serum stool samples collected at baseline, 4 16 weeks. Shotgun metagenomic...
PTEN loss has been associated with poorer prognosis in many solid tumors. However, such investigation lymphomas is limited. In this study, cytoplasmic and nuclear expression, gene deletion, mutations were evaluated two independent cohorts of diffuse large B-cell lymphoma (DLBCL). Cytoplasmic expression was found approximately 67% total 747 DLBCL cases, more frequently the activated B-cell–like subtype. Nuclear less frequent at lower levels, which significantly correlated higher mRNA...