A5100323531- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- CAR-T cell therapy research
- Mesenchymal stem cell research
- PI3K/AKT/mTOR signaling in cancer
- Galectins and Cancer Biology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Tissue Engineering and Regenerative Medicine
- Ubiquitin and proteasome pathways
- Acute Lymphoblastic Leukemia research
- Bone Tissue Engineering Materials
- Single-cell and spatial transcriptomics
- Biochemical and Molecular Research
- Radiomics and Machine Learning in Medical Imaging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Mechanisms and Therapy
- MRI in cancer diagnosis
- RNA modifications and cancer
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
University of Chicago Medical Center
2023-2025
Molecular Oncology (United States)
2023-2025
Chongqing University
2023-2025
Chongqing Cancer Hospital
2023-2025
Breast Center
2024
XinHua Hospital
2023-2024
Affiliated Hospital of Qingdao University
2021-2023
Qingdao University
2015-2023
University College London
2023
United States Department of the Navy
2023
Metabolic reprogramming is linked to cancer cell growth and proliferation, metastasis, therapeutic resistance in a multitude of cancers. Targeting dysregulated metabolic pathways overcome resistance, an urgent clinical need all relapsed/refractory cancers, remains difficult. Through genomic analyses specimens, we show that toward oxidative phosphorylation (OXPHOS) glutaminolysis associated with the Bruton's tyrosine kinase inhibitor ibrutinib mantle lymphoma (MCL), B subtype poor outcomes....
Effective bone regeneration through tissue engineering requires a combination of osteogenic progenitors, osteoinductive biofactors and biocompatible scaffold materials. Mesenchymal stem cells (MSCs) represent the most promising seed for engineering. As multipotent that can self-renew differentiate into multiple lineages including fat, MSCs be isolated from numerous tissues exhibit varied differentiation potential. To identify an optimal progenitor cell source engineering, we analyzed...
Abstract Autophagy is an evolutionarily conserved cell survival pathway that enables cells to recoup ATP and other critical biosynthetic molecules during nutrient deprivation or exposure hypoxia, which are hallmarks of the tumour microenvironment. has been implicated as a potential mechanism resistance anticancer agents it can promote in face stress induced by chemotherapeutic breaking down cellular components generate alternative sources energy. Disruption autophagy with chloroquine (CQ)...
Purpose: B-cell lymphoma-2 (BCL-2), an antiapoptotic protein often dysregulated in lymphomas, promotes cell survival and provides protection from stress. A recent phase I first-in-human study of the BCL-2 inhibitor venetoclax non-Hodgkin lymphoma showed overall response rate 44%. These promising clinical results prompted our examination biological effects mechanism action underlying activity aggressive lymphoma, including mantle (MCL) diffuse large (DLBCL).Experimental Design: MCL DLBCL...
Abstract Development of effective therapeutic strategies to eliminate cancer stem cells, which play a major role in drug resistance and disease recurrence, is critical improve treatment outcomes. Our study showed that glioblastoma cells (GSCs) exhibited low mitochondrial respiration high glycolytic activity. These GSCs were highly resistant standard drugs such as carmustine temozolomide (TMZ), but sensitivity inhibitor 3-bromo-2-oxopropionate-1-propyl ester (3-BrOP), especially under hypoxic...
Liquid biopsy offers a minimally invasive tool to diagnose and monitor the heterogeneous molecular landscape of tumors over time therapy. Detection TERT promoter mutations (C228T, C250T) in cfDNA has been successful for some systemic cancers but yet be demonstrated gliomas, despite high prevalence these glioma tissue (>60% all tumors).Here, we developed novel digital droplet PCR (ddPCR) assay that incorporates features improve sensitivity allows simultaneous detection longitudinal monitoring...
Socioeconomic status (SES) is a determinant of cognitive and academic functioning among healthy ill children; however, few pediatric oncology studies examine SES long-term functioning. The current study systematically investigated as predictor outcomes children treated for localized brain tumors (BT) with photon radiation therapy (RT).248 on prospective, longitudinal, phase II trial conformal RT (54-59.4 Gy) ependymoma, low-grade glioma, or craniopharyngioma were monitored serially...
Abstract Purpose: Patients with B-cell lymphomas often relapse after frontline therapy, and novel therapies are urgently needed to provide long-term remission. We established lymphoma patient-derived xenograft (PDX) models assess their ability mimic tumor biology identify patient treatment options. Experimental Design: the PDX from 16 patients diffuse large lymphoma, mantle cell follicular marginal zone or Burkitt by inoculating cells into a human bone chip implanted mice. subjected...
Neuronal apoptosis has been well-recognized as a critical mediator in the pathogenesis of depressive disorders. Tissue kallikrein-related peptidase 8 (KLK8), trypsin-like serine protease, implicated several psychiatric The present study aimed to explore potential function KLK8 hippocampal neuronal cell associated with disorders rodent models chronic unpredictable mild stress (CUMS)-induced depression. It was found that depression-like behavior CUMS-induced mice upregulation. Transgenic...
The present study investigated the specific mechanism by which mesenchymal stem cells (MSCs) protect against sepsis-associated acute kidney injury (SA-AKI).Male C57BL/6 mice underwent cecal ligation and puncture surgery to induce sepsis then received either normal IgG or MSCs (1 × 106 cells, intravenously) plus Gal-9 soluble Tim-3 3 h after surgery.After surgery, injected with had a higher survival rate than in treatment group. Treatment decreased serum creatinine blood urea nitrogen levels,...
Bromodomain-containing protein (BRD) play a pivotal role in the development and progression of malignant tumours. This study aims to identify prognostic genes linked BRD-related (BRDRGs) patients with triple-negative breast cancer (TNBC) construct novel model. Data from TCGA-TNBC, GSE135565, GSE161529 were retrieved public databases. was used key cell types. The BRDRGs score TCGA-TNBC calculated using single-sample Gene Set Enrichment Analysis (ssGSEA). Differential expression analysis...
Intervertebral disc (IVD) degeneration (IVDD), primarily caused by nucleus pulposus (NP) dehydration, leads to low back pain. While current treatments focus on symptom management or surgical intervention, tissue engineering using IVD-derived cells, biofactors, and scaffolds offers a promising regenerative approach. Here, human NP cells (NPCs) annulus fibrosus (AFCs) are immortalized with telomerase reverse transcriptase (hTERT), generating NPCs (iHNPCs) AFCs (iHAFCs). These express...
Abstract Paclitaxel is one of the most widely used antineoplastic drugs in clinic. Unfortunately, occurrence cellular resistance has limited its efficacy and application. The ATP-binding cassette subfamily B member 1 (ABCB1/P-glycoprotein) C 10 (ABCC10/MRP7) are major membrane protein transporters responsible for efflux paclitaxel, constituting important mechanisms paclitaxel resistance. Here, we demonstrated that Bruton tyrosine kinase inhibitor, ibrutinib, significantly enhanced antitumor...
BACKGROUND: With the advent of molecular era, diagnosis and treatment systems glioma have also changed. A single histological type cannot be used for prognosis grade. Only by combining can precision medicine realized. OBJECTIVE: To develop an automatic integrated gene detection system (AIGS) intraoperative in to explore its positive role treatment. METHODS: We analyzed isocitrate dehydrogenase 1 (IDH1) mutation status 105 samples evaluated product's potential value diagnosis; 37 were...
Abstract Background Hirsutanol A is a novel sesquiterpene compound purified from fungus Chondrostereum sp. in Sarcophyton tortuosum . Our previous studies had demonstrated that hirsutanol exhibited potent cytotoxic effect on many kinds of cancer cell lines. In the current study, antitumor activity and its molecular mechanisms were investigated. Methods induced growth inhibition apoptotic death human colon SW620 cells breast MDA-MB-231cells determined using MTT assay flow cytometry assay,...