A5100349679- Lymphoma Diagnosis and Treatment
- Cancer and Skin Lesions
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Genetic and rare skin diseases.
- Urologic and reproductive health conditions
- Monoclonal and Polyclonal Antibodies Research
- Nonmelanoma Skin Cancer Studies
- Vascular Tumors and Angiosarcomas
- Cutaneous Melanoma Detection and Management
- Cancer Genomics and Diagnostics
- Mosquito-borne diseases and control
- Dermatological and Skeletal Disorders
- Oral Health Pathology and Treatment
- Acne and Rosacea Treatments and Effects
- Dermatologic Treatments and Research
- Tuberculosis Research and Epidemiology
- Atrial Fibrillation Management and Outcomes
- Streptococcal Infections and Treatments
- Bladder and Urothelial Cancer Treatments
- Diverse Scientific Research Studies
- Infectious Diseases and Mycology
- Autoimmune and Inflammatory Disorders
- Galectins and Cancer Biology
National Institute of Pathology
2017-2025
Indian Council of Medical Research
2012-2025
Safdarjang Hospital
2012-2025
Ministry of Health and Family Welfare
2022-2024
Narsee Monjee Institute of Management Studies
2024
Sharda University
2023-2024
Post Graduate Institute of Medical Education and Research
1988-2024
University of Modern Sciences
2024
IMS Unison University
2023-2024
Natera (United States)
2019-2024
BackgroundAsthma is the most common chronic disease in children globally. The Global Asthma Network (GAN) Phase I study aimed to determine if worldwide burden of asthma symptoms changing.MethodsThis updated cross-sectional used same methods as International and Allergies Childhood (ISAAC) III. were assessed from centres that completed GAN ISAAC (1993–95), III (2001–03), or both. We included individuals two age groups (children aged 6–7 years adolescents 13–14 years) who self-completed...
The anonymous nature of darknets is commonly exploited for illegal activities. Previous research has employed machine learning and deep techniques to automate the detection darknet traffic in an attempt block these criminal This aims improve by assessing a wide variety classification such underlying application types. We find that Random Forest model outperforms other state-of-the-art used prior work with CIC-Darknet2020 dataset. To evaluate robustness our classifier, we obfuscate select...
Abstract Introduction Personalized and tumor-informed circulating tumor DNA (ctDNA) testing is feasible allows for molecular residual disease (MRD) identification in patients with pancreatic ductal adenocarcinoma (PDAC). Methods In this retrospective analysis of commercial cases from multiple US institutions, personalized, tumor-informed, whole-exome sequenced, germline-controlled ctDNA levels were quantified analyzed PDAC. Plasma samples (n = 1329) 298 clinically validated collected at...
Significance Na + -coupled symporters use the cellular gradient to power transport of physiologically important molecules across lipid membrane. However, mechanism by which binding and dissociation drive remains undefined. This work investigated /hydantoin transporter Mhp1, a member LeuT-fold class transporters, describe conformations sampled during its cycle elucidate ligand-induced shifts in conformational equilibrium. The results this study suggest that Mhp1 isomerization between inward-...
Abstract Purpose: Patients with B-cell lymphomas often relapse after frontline therapy, and novel therapies are urgently needed to provide long-term remission. We established lymphoma patient-derived xenograft (PDX) models assess their ability mimic tumor biology identify patient treatment options. Experimental Design: the PDX from 16 patients diffuse large lymphoma, mantle cell follicular marginal zone or Burkitt by inoculating cells into a human bone chip implanted mice. subjected...
Despite curative-intent radical cystectomy (RC), patients with muscle-invasive bladder cancer (MIBC) are at high risk of recurrence. Biomarkers urgently needed to refine prognostication and selection appropriate perioperative systemic therapies. Our aim was evaluate the prognostic predictive value tumor-informed circulating tumor DNA (ctDNA) results in a multicenter cohort who underwent RC.
Background. Artemisinin-based combination therapy is the first-line treatment for uncomplicated falciparum malaria. This study assessed antimalarial efficacy and safety of a 150 mg arterolane maleate 750 piperaquine phosphate (AM-PQP) in comparison to Coartem (artemether lumefantrine) patients with acute P. Methods. In this open-label, randomized, multicentric, parallel group clinical trial, 240 were randomized receive AM-PQP (160 patients) or (80 patients). Patients monoinfection initial...
To compare the free and total plasma drug concentrations of rifampicin (RMP), isoniazid pyrazinamide in subjects with or without anti-tuberculosis drug-induced hepatotoxicity (DIH).A 110 tuberculosis (TB) patients were administered daily treatment prospectively followed for development DIH. Plasma levels measured at 0, 1, 2 4 h on days 7 14 treatment. 15 who developed DIH (cases) compared 95 did not (controls).Female sex, body mass index < 17 kg/m(2) baseline serum albumin g/dl predicted...
Abstract Inhibition of B-cell receptor (BCR) signaling through the BTK inhibitor, ibrutinib, has generated a remarkable response in mantle cell lymphoma (MCL). However, approximately one third patients do not respond well to drug, and disease relapse on ibrutinib is nearly universal. Alternative therapeutic strategies aimed prevent overcome resistance are needed. We compared contrasted effects selinexor, selective inhibitor nuclear export, with six MCL lines that display differential...
Chikungunya fever is a benign and self-limiting disease caused by an RNA virus belonging to genus alphavirus transmitted infected Aedes mosquitoes. However, number of atypical presentations involving various systems have been reported. Among the neurological complications, encephalitis, myelitis, Guillain-Barre syndrome optic neuritis are commonly seen. its presentation as isolated inflammatory myositis causing quadriplegia extremely rare. We report 35-year-old woman with chikungunya-induced...
With the current pandemic of novel coronavirus disease 2019 (COVID-19) in hand, researchers around globe are dexterously working to find best suitable drug candidates and overcome vaccination-related challenges, achieve efficient control over second surge COVID-19. The medical consultants time again have been reiterating need abide by precautionary steps prevent spread maintaining social distancing when outside, sanitizing hands regularly, wearing masks gloves. They also suggest taking a...
Squamous cell carcinoma (SCC) of a nail unit is an uncommon tumour with low metastatic potential. These tumours are commonly misdiagnosed due to their variable presentation. We report case 53-year-old female presenting solitary, painless growth bleeding tendency, present over her right index finger, persisting for 4 years. Histopathological examination confirmed the diagnosis SCC. This aims highlight clinical presentation, diagnostic approach and treatment SCC in unusual location,...
In the current scenario, treatment of Post Kala Azar Dermal leishmaniasis (PKDL) is intravenous liposomal amphotericin B or oral miltefosine. Over years, there has been a gradual decline in efficacy miltefosine and rise permanent loss vision. Moreover, non-endemic states, not freely available. view this, we attempted two step regimen itraconazole to treat patients PKDL diagnosed on histopathology as well PCR. We found this be highly effective with complete recovery.
Dermal melanocytoses are characterised by the presence of spindle-shaped melanocytes in dermis. The common forms, such as Mongolian spots, and nevi Ota or Ito, present from birth puberty, while acquired dermal appear adulthood rare. They frequently misdiagnosed lichen planus pigmentosus melasma leading to delay treatment. This study reports five cases unilateral nevus India, with an analysis their dermoscopic histopathological features.
Abstract Background: Tumor-informed circulating tumor (ct) DNA testing is recognized as a powerful predictor of CRC recurrence. However, the benefit systemic therapy to prevent or delay clinical recurrence in patients (pts) with molecular after curative surgery remains uncertain. Methods: Pts who had undergone resection primary and/or metastatic sites + standard care (SoC) adjuvant treatment, if applicable, were enrolled ALTAIR study they (1) prospectively tested positive for ctDNA using...