A5081225502- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Respiratory viral infections research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 epidemiological studies
- Viral gastroenteritis research and epidemiology
- Cutaneous lymphoproliferative disorders research
- Radiopharmaceutical Chemistry and Applications
- Biochemical and Molecular Research
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- Galectins and Cancer Biology
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Viral Infections and Outbreaks Research
- Vaccine Coverage and Hesitancy
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Child Nutrition and Water Access
- Genetic factors in colorectal cancer
- Immunodeficiency and Autoimmune Disorders
The University of Sydney
2025
AstraZeneca (United States)
2024
Southampton General Hospital
2024
AstraZeneca (Brazil)
2024
Sanofi (United States)
2019-2022
International Centre for Diarrhoeal Disease Research
1983-2020
The University of Texas MD Anderson Cancer Center
1998-2019
Lymphoma Research Foundation
2018
The University of Texas Health Science Center at Houston
2016-2017
Office of Infectious Diseases
2017
Metabolic reprogramming is linked to cancer cell growth and proliferation, metastasis, therapeutic resistance in a multitude of cancers. Targeting dysregulated metabolic pathways overcome resistance, an urgent clinical need all relapsed/refractory cancers, remains difficult. Through genomic analyses specimens, we show that toward oxidative phosphorylation (OXPHOS) glutaminolysis associated with the Bruton's tyrosine kinase inhibitor ibrutinib mantle lymphoma (MCL), B subtype poor outcomes....
Summary Long term outcomes and mutations in patients with mantle cell lymphoma (MCL) who discontinued ibrutinib have not been described. Using deep targeted next generation sequencing, we performed somatic mutation profiling from 15 MCL (including 5 paired samples; before after progression on ibrutinib). We identified 80 therapy for various reasons. Median follow‐up discontinuation was 38 months. The median duration 7·6 Forty‐one (51%) due to disease progression/transformation, 20 (25%)...
Abstract Purpose: Patients with B-cell lymphomas often relapse after frontline therapy, and novel therapies are urgently needed to provide long-term remission. We established lymphoma patient-derived xenograft (PDX) models assess their ability mimic tumor biology identify patient treatment options. Experimental Design: the PDX from 16 patients diffuse large lymphoma, mantle cell follicular marginal zone or Burkitt by inoculating cells into a human bone chip implanted mice. subjected...
Rationale There is little evidence for the efficacy of handwashing prevention influenza transmission in resource-poor settings. We tested impact intensive promotion on household influenza-like illness and rural Bangladesh. Methods In 2009–10, we identified index case-patients with (fever cough or sore throat) who were only symptomatic person their household. Household compounds randomized to control intervention (soap daily promotion). conducted surveillance collected oropharyngeal...
Inappropriate dispensing of antibiotics for acute respiratory illness (ARI) is common among drug sellers in Bangladesh. In this study, we evaluated the impact an educational intervention to promote guidelines better ARI management sellers. From June 2012 December 2013, conducted baseline and post-intervention surveys on practices 100 pharmacies within Dhaka city. these surveys, participated 6 standardized role-playing scenarios led by study staffs acting as caregivers patients were blinded...
Schoolchildren are commonly linked to influenza transmission. Handwashing with soap has been shown decrease infections; however, improving handwashing practices using and water is difficult in low-resource settings. In these settings, alternative hygiene options, such as hand sanitizer, could improve promotion reduce virus infections. We conducted a cluster randomized control trial 24 primary schools Dhaka assess the effectiveness of sanitizer respiratory education intervention reducing...
Background Seasonal influenza‐associated mortality estimates help identify the burden of disease and assess value public health interventions such as annual influenza immunization. Vital registration is limited in Bangladesh making it difficult to estimate seasonal mortality. Objectives Our study aimed rates for 2010‐2012 Bangladesh. Methods We conducted surveillance among hospitalized patients with severe acute respiratory illness ( SARI ) persons aged ≥5 years pneumonia children <5 11...
The International Health Regulations outline core requirements to ensure the detection of public health threats international concern. Assessing capacity surveillance systems detect these is crucial for evaluating a country's ability meet requirements.We propose framework evaluate sensitivity and representativeness hospital-based apply it severe neurological infectious diseases fatal respiratory in Bangladesh. We identified cases selected communities within hospital catchment areas using key...
We combined hospital-based surveillance and health utilization survey data to estimate the incidence of respiratory viral infections associated hospitalization among children aged < 5 years in Bangladesh.
Background: Pharmacies in Bangladesh serve as an important source of health service. A survey Dhaka reported that 48% respondents with symptoms acute respiratory illness (ARI) identified local pharmacies their first point care. This study explores the factors driving urban customers to seek care from for ARI, treatment adherence, and outcome. Methods: cross-sectional was conducted among 100 selected within June December 2012. Study participants were patients or patients' relatives aged >18...
Global influenza-associated acute respiratory infections contribute to 3-5 million severe illnesses requiring hospitalization annually, with 90% of hospitalizations occurring among children < 5 years in developing countries. In Bangladesh, the inadequate availability nationally representative, robust estimates limits allocation resources for prevention and control measures.
Rotavirus vaccines have significantly decreased the burden of diarrheal diseases in countries that introduced them into their immunization programs. In some studies, there has been a small association between rotavirus and intussusception post-marketing surveillance, highlighting importance tracking incidence before after vaccine introduction. The objective this study was to describe epidemiology among Bangladeshi children pre-vaccine We conducted active, hospital-based surveillance for at 7...
Abstract In relapsed and refractory multiple myeloma (RRMM), there are few treatment options once patients progress from the established standard of care. Several bispecific T-cell engagers (TCE) in clinical development for (MM), designed to promote activation tumor killing by binding a receptor target. this study we employ both computational experimental tools investigate how novel trispecific TCE improves activation, proliferation, cytolytic activity T-cells against MM cells. addition CD3...