A5032790049- Vector-borne infectious diseases
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Respiratory viral infections research
- Vector-Borne Animal Diseases
- Malaria Research and Control
- COVID-19 epidemiological studies
- Child Nutrition and Water Access
- Water resources management and optimization
- Wastewater Treatment and Reuse
- Data-Driven Disease Surveillance
- Vaccine Coverage and Hesitancy
- Water-Energy-Food Nexus Studies
- Pesticide Exposure and Toxicity
- Pneumonia and Respiratory Infections
- Emergency and Acute Care Studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Insect and Pesticide Research
- Dermatological diseases and infestations
- Viral Infections and Outbreaks Research
- Travel-related health issues
- Climate Change and Health Impacts
- Viral gastroenteritis research and epidemiology
National Institute for Public Health and the Environment
2013-2022
Health Forecasting
2013-2021
Utrecht University
2015-2020
European Centre for Disease Prevention and Control
2018-2020
University Medical Center Utrecht
2019
Radboud University Nijmegen
2019
Radboud University Medical Center
2019
European Bioinformatics Institute
2019
University of Oxford
2019
Institut de Génétique Humaine
2019
Q fever is a disease of humans, caused by Coxiella burnetii, and large range animals can be infected. This paper presents review the epidemiology in humans farm between 1982 2010, using case studies from four European countries (Bulgaria, France, Germany Netherlands). The Netherlands had outbreak 2007 other history research. Within all countries, serological prevalence C. burnetii infection reported incidence varies broadly both humans. Proximity to contact with infected or their birth...
Since the steady rise in human cases which started 2007, Q fever has become a major public health problem Netherlands with 2,357 notified year 2009. Ongoing research confirms that abortion waves on dairy goat farms are primary source of infection for humans, primarily affecting people living close (under 5 km) to such farm. To reverse trend last three years, drastic measures have been implemented, including large-scale culling pregnant goats infected farms.
A nationwide assessment in Pakistan showed that the direct use of untreated wastewater for agriculture, particularly vegetable production, was common most cities. The main reasons this were absence alternative water sources, reliability supply, nutrient value and proximity to urban markets. It estimated 26% total domestic production cultivated with wastewater. importance re.ected high land fees. Policy makers have take local livelihoods food security into account when making decisions regarding use.
We describe the Q fever epidemic in Netherlands with emphasis on epidemiological characteristics of acute patients and association veterinary factors. Data from 3264 notifications for period 2007 through 2009 were analysed. The most affected men, smokers persons aged 40-60 years. Pneumonia was common clinical presentation (62% 2008). Only 3.2% working agriculture sector 0.5% meat-processing industry including abattoirs. Dairy goat farms Coxiella burnetii-induced abortion waves mainly located...
A Q-fever outbreak occurred in an urban area the south of Netherlands May 2008. The distribution and timing cases suggested a common source. We studied spatial relationship between residence locations human nearby small ruminant farms, which one dairy goat farm had experienced abortions due to since mid April generic geographic information system (GIS) was used develop method for source detection still evolving major epidemic Netherlands.All notified were interviewed. Postal codes farms...
Background.Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance data were available. Methods.On time series (1999–2007) used regression models associate total death counts individuals aged 65–74, 75–84, ≥85 years (a population 2.5 million) with pathogen circulation—influenza A (season-specific), influenza B, respiratory...
To rapidly assess possible community transmission in Noord-Brabant, the Netherlands, healthcare workers (HCW) with mild respiratory complaints and without epidemiological link (contact confirmed case or visited areas active circulation) were tested for severe acute syndrome coronavirus 2 (SARS-CoV-2). Within days, 1,097 HCW nine hospitals tested; 45 (4.1%) positive. Of six positive HCW, two accounted 38 HCW. The results informed local national risk management.
Indoor environments are considered one of the main settings for transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Households in particular represent a close-contact environment with high probability between persons different ages and roles society.
Even if drinking water of poor rural communities is obtained from a 'safe' source, it can become contaminated during storage in the house. To investigate relative importance this domestic domain contamination, 5-week intervention study was conducted. Sixty-seven households Punjab, Pakistan, were provided with new containers (pitchers): 33 received traditional wide-necked pitcher normally used area and remaining 34 narrow-necked pitcher, preventing direct hand contact water. Results showed...
The Netherlands is again facing a sharp increase in Q fever notifications, after the unprecedented outbreaks of 2007 and 2008. most affected province Noord Brabant has high density large dairy goat farms, farms with abortion waves have been incriminated. Mandatory vaccination small ruminants started should an effect 2010. A multidisciplinary research portfolio expected to generate better knowledge about transmission additional control measures.
Q fever is a worldwide zoonosis caused by the bacterium Coxiella burnetii which common in wide range of wild and domestic animals. Cattle small ruminants, particular sheep goats, have been associated with large human outbreaks. Humans become infected primarily inhaling aerosols that are contaminated C. burnetii. Most infections remain asymptomatic but about 40% lead to febrile disease, pneumonia and/or hepatitis. Chronic infections, mainly endocarditis, observed 3 5% cases, an increased risk...
The Netherlands is facing a Q fever epidemic in which dairy goats are implicated. People living close to an affected farm have increased risk. However, no human cases were reported around number of farms with serious problems. To assess the role local environmental conditions may add transmission or risk fever, we gathered datasets on vegetation, land use, soil characteristics, and weather 5 km areas infected farms. Areas without had higher vegetation density relatively shallow groundwater...
Background. Recent outbreaks in the Netherlands allowed for laboratory follow-up of a large series patients with acute Q fever and evaluation test algorithms to detect chronic fever, condition considerable morbidity mortality. Methods. For 686 IgG antibodies Coxiella burnetii were determined using an immunofluorescence assay at 3, 6, 12 months follow-up. Polymerase chain reaction (PCR) was performed after on earlier serum samples phase I antibody titer ≥1:1024. Results. In 43% patients, II...
BACKGROUND: In 2007, 2008, and 2009 outbreaks of Q‐fever occurred in the Netherlands with increasing magnitude. The outbreak 2354 reported cases is largest human ever recorded. To assess extent infection safety donated blood, we tested local blood donations for presence Coxiella burnetii antibodies DNA. STUDY DESIGN AND METHODS: Starting May 2009, more than 40,000 serum samples were collected from all consenting donors areas high incidence. 1004 highest number C. DNA by polymerase chain...