A5064455712- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Travel-related health issues
- Dermatological diseases and infestations
- Parasitic Infections and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- Amoebic Infections and Treatments
- Rabies epidemiology and control
- Legionella and Acanthamoeba research
- Ocular Infections and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Virology and Viral Diseases
- Insect and Pesticide Research
- Zoonotic diseases and public health
- Salmonella and Campylobacter epidemiology
- Food Safety and Hygiene
- Leptospirosis research and findings
- COVID-19 epidemiological studies
- Malaria Research and Control
- Bacillus and Francisella bacterial research
- Hepatitis Viruses Studies and Epidemiology
National Institute for Public Health and the Environment
2012-2025
National Research Institute for Veterinary Virology and Microbiology of Russia
2021
Utrecht University
2020
European Centre for Disease Prevention and Control
2006-2014
Radboud University Nijmegen
2010-2014
Radboud University Medical Center
2010-2014
De Gezondheidsdienst voor Dieren
2014
Eindhoven Cancer Registry
2012
Health Forecasting
2009
Norwegian Institute of Public Health
2006-2008
Dengue is the most important arthropod-borne viral disease of public health significance. Compared with nine reporting countries in 1950s, today geographic distribution includes more than 100 worldwide. Many these had not reported dengue for 20 or years and several have no known history disease. The World Health Organization estimates that 2.5 billion people are at risk infection. First recognised it has become a leading cause child mortality Asian South American countries.This paper reviews...
Since the steady rise in human cases which started 2007, Q fever has become a major public health problem Netherlands with 2,357 notified year 2009. Ongoing research confirms that abortion waves on dairy goat farms are primary source of infection for humans, primarily affecting people living close (under 5 km) to such farm. To reverse trend last three years, drastic measures have been implemented, including large-scale culling pregnant goats infected farms.
We describe the Q fever epidemic in Netherlands with emphasis on epidemiological characteristics of acute patients and association veterinary factors. Data from 3264 notifications for period 2007 through 2009 were analysed. The most affected men, smokers persons aged 40-60 years. Pneumonia was common clinical presentation (62% 2008). Only 3.2% working agriculture sector 0.5% meat-processing industry including abattoirs. Dairy goat farms Coxiella burnetii-induced abortion waves mainly located...
A Q-fever outbreak occurred in an urban area the south of Netherlands May 2008. The distribution and timing cases suggested a common source. We studied spatial relationship between residence locations human nearby small ruminant farms, which one dairy goat farm had experienced abortions due to since mid April generic geographic information system (GIS) was used develop method for source detection still evolving major epidemic Netherlands.All notified were interviewed. Postal codes farms...
Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase laboratory confirmed giardiasis was city Bergen. An investigation started to determine source extent outbreak order implement control measures. Cases were identified through conducting giardia diagnostics area. All laboratory-confirmed mapped based on address residence, attack rates relative risks calculated for each water supply zone. A case study conducted...
On 20-21 February 2006, six cases of diarrhoea-associated haemolytic uraemic syndrome (HUS) were reported by paediatricians to the Norwegian Institute Public Health. We initiated an investigation identify etiologic agent and determine source outbreak in order implement control measures.A case was defined as a child with HUS or any person infection strain E. coli O103 (defined multi-locus variable number tandem repeats analysis (MLVA) profile) both illness onset after January 1st 2006 Norway....
Background Despite the comprehensive World Health Organization (WHO)/United Nations Children's Fund (UNICEF) measles mortality–reduction strategy and Measles Initiative, a partnership of international organizations supporting mortality reduction in Africa, certain high-burden countries continue to face recurrent epidemics. To our knowledge, few recent studies have documented sub-Saharan Africa. The objective study was investigate three epidemics Niamey (Niger), N'Djamena (Chad), Adamawa...
In May 2013, Italy declared a national outbreak of hepatitis A, which also affected several foreign tourists who had recently visited the country. Molecular investigations identified some cases as infected with an identical strain A virus subgenotype IA. After additional European Union/European Economic Area (EU/EEA) countries reported locally acquired and travel-related associated same outbreak, international investigation team was convened, case definition issued harmonisation...
A Q fever outbreak occurred in the southeast of The Netherlands spring and summer 2007. Risk factors for acquisition a recent Coxiella burnetii infection were studied. In total, 696 inhabitants cluster area invited to complete questionnaire provide blood sample serological testing IgG IgM phases I II antibodies against C. burnetii, order recruit seronegative controls case-control study. Questionnaires also sent 35 previously identified clinical cases. Limited environmental sampling focused...
The Netherlands is again facing a sharp increase in Q fever notifications, after the unprecedented outbreaks of 2007 and 2008. most affected province Noord Brabant has high density large dairy goat farms, farms with abortion waves have been incriminated. Mandatory vaccination small ruminants started should an effect 2010. A multidisciplinary research portfolio expected to generate better knowledge about transmission additional control measures.
Between 14 September and 20 October 2007, an outbreak of Shiga toxin-producing Escherichia coli (STEC) O157 simultaneously occurred in the Netherlands Iceland. A total 50 laboratory-confirmed cases were reported with a STEC infection caused by same clone. The strain was type O157:H-, PT8, positive for stx 1 , 2 eae e-hly, sorbitol negative. most probable cause this international contaminated lettuce, shredded pre-packed Dutch food processing plant. Samples environment, raw produce end...
Q fever is a worldwide zoonosis caused by the bacterium Coxiella burnetii which common in wide range of wild and domestic animals. Cattle small ruminants, particular sheep goats, have been associated with large human outbreaks. Humans become infected primarily inhaling aerosols that are contaminated C. burnetii. Most infections remain asymptomatic but about 40% lead to febrile disease, pneumonia and/or hepatitis. Chronic infections, mainly endocarditis, observed 3 5% cases, an increased risk...
Abstract An outbreak involving 11 persons infected with Yersinia enterocolitica O:9 was investigated in Norway February 2006. A case-control study and microbiologic investigation indicated a ready-to-eat pork product as the probable source. Appropriate control measures are needed to address consumer risk associated this product.
The aim of this study was to estimate the seroprevalence Coxiella burnetii in dairy goat farms Netherlands and identify risk factors for farm seropositivity before mandatory vaccination started. We approached 334 eligible with more than 100 goats serum sampling a questionnaire. Per farm, median 21 were sampled. A considered positive when at least one tested ELISA positive. In total, 2,828 samples from 123 available. Farm prevalence 43.1% (95%CI: 34.3%-51.8%). Overall 21.4% 19.9%-22.9%) among...
The Netherlands has experienced large community outbreaks of Q fever since 2007. Sera and questionnaires containing epidemiological data from 5654 individuals were obtained in a nationwide seroprevalence survey used to evaluate the National Immunization Programme 2006-2007. We tested these sera for IgG phase-2 antibodies against Coxiella burnetii with an ELISA estimate identify determinants seropositivity before occurred. Overall was 1·5% [95% confidence interval (CI) 1·3-1·7]. Corrected...
Background Q fever is an occupational risk for veterinarians, however little known about the veterinary medicine students. This study aimed to assess seroprevalence of Coxiella burnetii among students and identify associated factors. Methods A cross-sectional with questionnaire blood sample collection was performed all studying in Netherlands 2006. Serum samples (n = 674), representative years directions, were analyzed C. IgG IgM phase I II antibodies immunofluorescence assay (IFA)....
During large Q fever outbreaks in the Netherlands between 2007 and 2010, dairy goat farms were implicated as primary source of human fever. The transmission Coxiella burnetii to humans is thought occur primarily via aerosols, although available data on C. aerosols other environmental matrices are limited. outbreak 2009, 19 one sheep farm selected nationwide investigate presence DNA vaginal swabs, manure, surface area milk unit filters, aerosols. Four these had a positive status during bulk...
In the Netherlands, 97 human leptospirosis cases were notified in 2014. This represents a 4.6-fold increase autochthonous (n = 60) compared with annual average between 2010 and 2013. Most had symptom onset June November. marked humans coincided an of dogs. 2014, 13 dogs reported, two to six annually from The majority 20) linked recreational exposure, e.g. swimming or fishing, followed by occupational exposure 15). About sixty per cent 37) most likely attributable surface water contact,...
Introduction Several Public Health Services and general practitioners in the Netherlands observed an increase scabies Netherlands. Since individual cases of are not notifiable Netherlands, epidemiological situation is mostly unknown. To investigate incidence we described epidemiology between 2011 2021. Methods Two national data sources were analysed descriptively. One source obtained (per 1,000 persons) persons consulting primary care from 2011–2020. The other captured number prescribed...
Community Q fever epidemics occurred in the Netherlands 2007–2009, with dairy goat and sheep farms as implicated source. The aim of study was to determine seroprevalence risk factors for seropositivity farmers their household members living or working on these farms. Sera 268 people 111 were tested Coxiella burnetii IgG IgM antibodies using immunofluorescence assay. Seroprevalences farmers, spouses children (12–17 years) 73.5%, 66.7%, 57.1%, respectively. Risk were: performing three more...
Q fever, caused by Coxiella burnetii, is a recognized occupational infection in persons who have regular contact with ruminants. We determined C. burnetii seroprevalence residents living or working on dairy cattle farms ≥50 adult cows and identified risk factors for seropositivity. Serum samples from farm residents, including employees, were tested IgG IgM; was 72.1% overall 87.2%, 54.5%, 44.2% among farmers, spouses, children, respectively. Risk included location southern region, larger...
Since 2007, Q fever has become a major public health problem in the Netherlands and goats were most likely source of human outbreaks 2008 2009. Little was known about consequences these for those professional care providers directly involved. The aim this survey to estimate seroprevalence antibodies against C. burnetii among Dutch livestock veterinarians determine possible risk factors. Single blood samples from 189 veterinarians, including veterinary students their final year, collected at...
During the COVID-19 pandemic, there was a significant decline in number of patients with both non-urgent and urgent ophthalmologic conditions presenting to emergency departments, leading concerns about whereabouts need care. We hypothesized that an actual decrease microbial keratitis (MK) cases, due reduced contact lens (CL) wear improved hand hygiene, including alcohol-based disinfection. Besides, we questioned if non-pharmaceutical interventions would have sustained effect after pandemic....
SUMMARY Data about the effectiveness of different antibiotic regimens for treatment acute Q fever from clinical studies is scarce. We analysed patients in 2007 and 2008 The Netherlands assessed whether hospitalization after a minimum 2 days therapy was related to initial therapy. Clinical data on risk factors were obtained general practitioner medical records self-reported by patients. For 438 study patients, doxycycline most commonly prescribed both years. After adjustments confounding...