A5090166045- Parasitic Infections and Diagnostics
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Malaria Research and Control
- Hepatitis C virus research
- Amoebic Infections and Treatments
- Streptococcal Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Pneumonia and Respiratory Infections
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- Gastrointestinal motility and disorders
- Viral Infections and Immunology Research
- Child Nutrition and Water Access
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Virus-based gene therapy research
University of Bergen
2016-2025
Haukeland University Hospital
2016-2025
Haraldsplass Diakonale Sykehus
2019-2021
Collaborative Group (United States)
2021
NHS Blood and Transplant
2021
University of Oxford
2021
Science Oxford
2021
Hospital for Tropical Diseases
2021
Deaconess Hospital
2021
Weatherford College
2021
Abstract Long-term complications after coronavirus disease 2019 (COVID-19) are common in hospitalized patients, but the spectrum of symptoms milder cases needs further investigation. We conducted a long-term follow-up prospective cohort study 312 patients—247 home-isolated and 65 hospitalized—comprising 82% total Bergen during first pandemic wave Norway. At 6 months, 61% (189/312) all patients had persistent symptoms, which were independently associated with severity initial illness,...
Abstract Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS independent cohorts. conducted genome-wide association study 53,400 433,201 controls replicated significant associations in 23andMe panel (205,252 1,384,055 controls). Our confirmed six genetic loci IBS. Implicated...
ABSTRACT To assess the validity of reference values for hematologic and immunologic indices currently used in Africa, we evaluated blood samples from 3,311 human immunodeficiency virus (HIV)-negative Ugandans aged 1 week to 92 years. Erythrocyte, hemoglobin, hematocrit levels mean corpuscular volume all significantly increased with age ( P < 0.001) were independent gender until 13 years, after which higher males than females 0.001). White cell, neutrophil, lymphocyte, basophil, monocyte...
ABSTRACT Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 36]) and Klebsiella pneumoniae isolates (17% 52]) causing pediatric septicemia at a tertiary hospital Tanzania. Patients with due to ESBL-producing organisms had significantly higher fatality rate than those non-ESBL (71% versus 39%, P = 0.039). This is the first report CTX-M-15 genotype ESBLs on African continent observation SHV-12 an isolate Salmonella enterica serotype Newport.
Bloodstream infection is a common cause of hospitalization, morbidity and death in children. The impact antimicrobial resistance HIV on outcome not firmly established. We assessed the incidence bloodstream risk factors for fatal prospective cohort study 1828 consecutive admissions children aged zero to seven years with signs systemic infection. Blood was obtained culture, malaria microscopy, antibody test and, when necessary, PCR. recorded data clinical features, underlying diseases, drug...
Relatively few studies have been done in Tanzania to detect and classify diarrheagenic Escherichia coli (DEC) strains among children with diarrhea. This study aimed at investigating DEC Dar es Salaam aged less than five years hospitalized due acute/persistent were isolated from stool samples collected two hundred eighty diarrhea Muhimbili National Hospital Ilala Mwananyamala Municipal Hospitals Salaam. A multiplex PCR system method was used a species specific gene for E.coli ten different...
Giardia is not endemic in Norway, and more than 90% of reported cases acquire the infection abroad. In late October 2004, an increase laboratory confirmed giardiasis was city Bergen. An investigation started to determine source extent outbreak order implement control measures. Cases were identified through conducting giardia diagnostics area. All laboratory-confirmed mapped based on address residence, attack rates relative risks calculated for each water supply zone. A case study conducted...
<h3>Background</h3> <i>Giardia lamblia</i> is a common cause of gastroenteritis worldwide, but there limited knowledge about the long-term complications. <h3>Objective</h3> To estimate relative risk irritable bowel syndrome (IBS) and chronic fatigue 3 years after acute giardiasis. <h3>Design</h3> Controlled historic cohort study with years9 follow-up. Data collected by mailed questionnaire. <h3>Setting</h3> Waterborne outbreak giardiasis in city Bergen, Norway. <h3>Participants</h3> 817...
Functional gastrointestinal disorders (FGID) may occur following acute gastroenteritis. This long-term complication has previously not been described after infection with the non-invasive protozoan Giardia lamblia. study aims to characterize persistent abdominal symptoms elicited by according Rome II criteria and scores. Structured interview questionnaires 12–30 months onset of infection, at least 6 eradication, among 82 patients persisting infection. All had evaluated exclude other causes....
Previous trials investigating the efficacy of treatment durations shorter than standard 24 weeks for chronic hepatitis C virus (HCV) genotype 2/3 infections have yielded discordant results. The aims this investigator-initiated phase III study were to compare 12 or and identify patients suitable short-term therapy. Three hundred eighty-two 2/3–infected [intention-to-treat (ITT) population] at 31 centers in Denmark, Finland, Norway, Sweden randomized peginterferon α-2a (180 μg/week) plus...
Giardia infection in a nonendemic setting is associated with an increased risk for irritable bowel syndrome and chronic fatigue 6 years later. These conditions should be considered differential diagnosis patients persisting symptoms after eradication of the parasite. Background. Functional gastrointestinal disorders may follow acute infections. This study aimed to estimate persistence, prevalence, infection. Methods. We performed controlled prospective cohort 1252 individuals who had...
This study aimed to determine the age-specific aetiologic agents of diarrhoea in children aged less than five years. The also assessed efficacy empiric treatment childhood using Integrated Management Childhood Illness (IMCI) guidelines. included 280 5 years, admitted with any four major hospitals Dar es Salaam. Bacterial pathogens were identified conventional methods. Enzyme Linked Immunosorbent Assay (ELISA) and agglutination assay used detect viruses intestinal protozoa, respectively....
The objectives of this study were to determine the proportion malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, describe performance standard diagnostic methods. During April 2011–November 2012, 1564 aged ≥5 years febrile illness for 2–14 days consecutively included an observational at seven community hospitals six states India. Malaria microscopy, blood culture, Dengue rapid NS1 antigen IgM Combo...
Background Faecal carriage of ESBL-producing bacteria is a potential risk for transmission and infection. Little known about faecal antibiotic resistance in Tanzania. This study aimed to investigate the prevalence Enterobacteriaceae identify factors among young children Methodology/Principal Findings From August 2010 July 2011, below 2 years age were recruited Dar es Salaam, including healthy community (n = 250) hospitalized due diarrhoea or other diseases 103). ChromID ESBL agar CARBA SMART...
Klebsiella quasipneumoniae are Gram-negative bacteria of the family Enterobacteriaceae, distinguished from other members genus through a chromosomally encoded extended spectrum β-lactamase, blaOKP. Here, we report hybrid assembled genome novel sequence type subspecies similipneumoniae isolated faecal sample patient with sepsis.
ABSTRACT During the autumn and winter of 2004 2005, an extensive outbreak waterborne giardiasis occurred in Bergen, Norway. Over 1,500 patients were diagnosed with giardiasis. Analysis water from implicated source revealed low numbers Giardia cysts, but initial contamination event probably up to 10 weeks previously. While sewage leakage a residential area is now considered be probable contamination, during episode waste one particular septic tank was thought possible source. Genotyping cysts...
The Major Depression Inventory (MDI) was used to estimate the value of routine medical interviews in diagnosing major depression among patients receiving peginterferon alfa-2a and ribavirin therapy for chronic hepatitis C virus (HCV) infection (n = 325). According criteria from MDI Diagnostic Statistical Manual Mental Disorders (DSM-IV), 19 (6%) had at baseline. An additional 114 (37%) developed while on HCV combination therapy, with baseline score female sex independently predicting...
Background Although enteroparasites are common causes of diarrheal illness, few studies have been performed among children in Tanzania. This study aimed to investigate the prevalence Cryptosporidium parvum/hominis, Entamoeba histolytica and Giardia lamblia young Dar es Salaam, Tanzania, identify risk factors for infection. Methodology/Principal Findings We an unmatched case-control < 2 years age recruited from August 2010 July 2011. Detection identification protozoans were done by PCR...
Background. The importance of bacteria other than group A streptococci (GAS) in different clinical presentations cellulitis is unclear, commonly leading to treatment with broad-spectrum antibiotics. aim this study was describe the etiological and spectrum identify features predicting streptococcal etiology. Methods. We prospectively enrolled 216 patients hospitalized cellulitis. Clinical details were registered. Bacterial culture performed from blood, cutaneous or subcutaneous tissue, and/or...
Nested PCR is a commonly used technique in diagnosis of malaria owing to its high sensitivity and specificity. However, it time-consuming, open considerable risk contamination has low cost-efficiency. Using amplification targets presented multiple copies, such as rRNA 18S, or mitochondrial with an even higher copy number, might increase sensitivity.The specificity two newly designed Plasmodium genus-specific single-round programmes, based on previously published primers targeting 18S genome,...
Human adenovirus (HAdV) causes acute diarrhoea sporadically, as well in outbreaks. Understanding the prevalence and types of HAdV is important for control preventive measures, especially African region where there a high burden diarrhoeal disease. The present study assessed prevalence, molecular characteristics, seasonality associated clinical features infection Tanzanian children below two years age with without between 2010-2011.Stool specimens, demographic information were collected 690...
Irritable bowel syndrome (IBS) is a complication that can follow gastrointestinal infection, but it not clear if patients also develop chronic fatigue. We investigated the prevalence and odds ratio of IBS fatigue 10 years after an outbreak Giardia lamblia, compared with control cohort, changes in over time.We performed prospective follow-up study 1252 laboratory-confirmed cases giardiasis (exposed), which developed Bergen, Norway 2004. Statistics provided us information from 2504 unexposed...