A5037815059- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- RNA Research and Splicing
- Sulfur Compounds in Biology
- Nanoplatforms for cancer theranostics
- Hepatitis C virus research
- Nuclear Receptors and Signaling
- Cardiovascular Disease and Adiposity
- Cellular Mechanics and Interactions
- Endoplasmic Reticulum Stress and Disease
- Cancer Research and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Electron Microscopy Techniques and Applications
Qilu Hospital of Shandong University
2015-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2025
Wuhan University
2025
Renmin Hospital of Wuhan University
2025
Central Hospital of Zibo
2025
Sichuan Agricultural University
2024
Shandong University
2009-2024
Baogang Group (China)
2023
Chinese People's Liberation Army
2012-2022
Stanford University
2022
Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been shown to play an important role in pathophysiological processes TME remodelling various tumours.CircRNA sequencing analysis was performed explore circRNA expression profiles normal glioma tissues. The biological...
Abstract Exosomes participate in intercellular communication and glioma microenvironment modulation, but the exact mechanisms by which glioma-derived exosomes (GDEs) promote generation of immunosuppressive are still unclear. Here, we investigated effects GDEs on autophagy, polarization tumor-associated macrophages (TAMs), progression. Compared with normoxic (N-GDEs), hypoxic (H-GDEs) markedly facilitated autophagy M2-like macrophage polarization, subsequently promoted proliferation migration...
Glioblastoma (GBM) is one of the most fatal central nervous system tumors and lacks effective or sufficient therapies. Ferroptosis a newly discovered method programmed cell death opens new direction for GBM treatment. However, poor blood-brain barrier (BBB) penetration, reduced tumor targeting ability, potential compensatory mechanisms hinder effectiveness ferroptosis agents during Here, novel composite therapeutic platform combining magnetic features drug delivery properties nanoparticles...
Abstract Exosomes can selectively secrete harmful metabolic substances from cells to maintain cellular homeostasis, and complex crosstalk occurs between exosomes tumor-associated macrophages (TAMs) in the glioma immune microenvironment. However, precise mechanisms by which these exosome-encapsulated cargos create an immunosuppressive microenvironment remain unclear. Herein, we investigated effect of glioma-derived (GDEs) on macrophage polarization progression. We performed sequencing...
Myeloid‐derived suppressor cells (MDSCs) play a pivotal role in mediating the formation of an immunosuppressive environment and assisting tumors evading host immune response. However, mechanism through which manipulate differentiation function MDSCs remains unclear. Here, we report that hypoxia‐induced glioma can stimulate functional by transferring exosomal miR‐29a miR‐92a to MDSCs. Our results showed glioma‐derived exosomes (GEXs) enhance both vitro vivo , GEXs (H‐GEXs) demonstrated...
Hypoxia induces protective autophagy in glioblastoma cells and new therapeutic avenues that target this process may improve the outcome for patients. Recent studies have suggested autophagic is upregulated glioblastomas response to extensive hypoxia. also upregulation of a specific set proteins microRNAs (miRNAs) variety cell types. IL6 (interleukin 6), an inflammatory autocrine paracrine cytokine overexpressed glioblastoma, has been reported be biomarker poor prognosis because its...
Glioma is a heterogeneous cellular environment in which immune cells play critical roles tumor progression. Myeloid-derived suppressor (MDSCs) contribute to the formation of immunosuppressive microenvironment glioma; however, how glioma interact with MDSCs and this interaction affects function other are unclear. can systemically communicate via secretion exosomes, contain microRNAs (miRNAs). Leveraging miRNA sequencing we identified enrichment miR-1246 glioma-derived exosomes isolated from...
Abstract Patients with subarachnoid hemorrhage (SAH) often suffer from cognitive function impairments even when they have received proper treatment, such as the clipping or coiling of aneurysms, and this causes problems returning to work burdens family. Increasing attention has been paid mesenchymal stem cell (MSC)-derived extracellular vesicle (MSC-EV) promising therapeutic vesicles for stroke management. In study, we explored potential role MSC-EV in a rat model SAH. We observed that...
Proneural-to-mesenchymal transition (PMT) is a common process in glioblastoma (GBM) progression that leads to increased radiotherapy resistance. However, the mechanism underlying PMT poorly understood. Here, we found tumor-associated macrophages triggered glioma stem cells (GSC) via small extracellular vesicles (sEV). sEVs from monocyte-derived transferred miR-27a-3p, miR-22-3p, and miR-221-3p GSCs, these miRNAs promoted several mesenchymal phenotypes proneural (PN) GSCs by simultaneously...
Abstract Clear evidence shows that tumors could secrete microRNAs (miRNAs) via exosomes to modulate the tumor microenvironment (TME). However, mechanisms sorting specific miRNAs into are still unclear. In order study biological function and characterization of exosomal miRNAs, we performed whole-transcriptome sequencing in 59 patients’ whole-course cerebrospinal fluid (CSF) small extracellular vesicles (sEV) matched glioma tissue samples. The results demonstrate be divided exosome-enriched...
Resistance to temozolomide (TMZ) is a major obstacle preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play variety of roles in GBM, the lncRNAs that regulate TMZ resistance have not yet been clearly elucidated. This study aims identify may affect treatment sensitivity and explore novel therapeutic strategies overcome GBM.LncRNAs associated with were identified using Cancer Cell Line Encyclopedia (CCLE) Genomics Drug Sensitivity (GDSC) datasets....
Abstract Glioma is the most common malignant tumor of central nervous system in adults. The microenvironment (TME) related to poor prognosis glioma patients. cells could sort miRNA into exosomes modify TME. And hypoxia played an important role this sorting process, but mechanism not clear yet. Our study was find miRNAs sorted and reveal process. Sequencing analysis patients cerebrospinal fluid (CSF) tissue showed that miR-204-3p tends be exosomes. suppressed proliferation through...
Background: Glioma stem cells (GSCs) are a key factor in glioblastoma (GBM) development and treatment resistance.GSCs can be divided into the mesenchymal (MES) proneural (PN) subtypes, these two subtypes of GSCs undergo interconversion under certain conditions.MES have higher malignancy radioresistance closely associated with an immunosuppressive microenvironment.Long noncoding RNAs (lncRNAs) play broad role GBM, while subtype remains unknown.Methods: We performed RNA sequencing to explore...
Abstract Background Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and involved in regulation cell transformation. However, clinical significance, potential mechanism upstream regulators CUL7 malignant gliomas remain to be determined. Methods Expression level data information were obtained via Cancer Genome Atlas (TCGA) database, Chinese Glioma (CGGA) immunohistochemistry (IHC) western blot analysis. Gene set enrichment analysis (GSEA) was used explore molecular...
Vasculogenic mimicry (VM), the formation of an alternative microvascular circulation independent VEGF-driven angiogenesis, is reluctant to anti-angiogenesis therapy for glioma patients. However, treatments targeting VM are lacking due poor understanding molecular mechanism involved in formation. By analysing TCGA database, microRNA-29a-3p (miR-29a-3p) was found be highly expressed normal brain tissue compared with glioma. An vitro study revealed inhibitory role miR-29a-3p cell migration and...
Subarachnoid hemorrhage (SAH) is an acute and severe disease with high disability mortality. Inflammatory reactions have been proven to occur throughout SAH. Extracellular vesicles derived from mesenchymal stem cells (MSCs-EVs) shown broad potential for the treatment of brain dysfunction neuroprotective effects through neurogenesis angiogenesis after stroke. However, mechanisms EVs in neuroinflammation during phase SAH are not well known. Our present study was designed investigate MSCs-EVs...
Abstract This study was to develop a radiomics nomogram mainly using wavelet features for identifying malignant and benign early-stage lung nodules high-risk screening. A total of 116 patients with solitary pulmonary (SPNs) (≤ 3 cm) were divided into training set (N = 70) validation 46). Radiomics extracted from plain LDCT images each patient. signature then constructed the LASSO set. Combined independent risk factors, built multivariate logistic regression model. signature, consisting one...
Background Glioblastoma (GBM), one of the most aggressive tumors brain, has no effective or sufficient therapies. Identifying robust biomarkers for response to immune checkpoint blockade (ICB) therapy, a promising treatment option GBM patients, is urgently needed. Methods We comprehensively evaluated lncRNA m 6 A modification patterns in A-sequencing (m A-seq) data tissues and systematically investigated stromal regulators these A-regulated lncRNAs. used single-sample gene-set enrichment...
As one of the most common post-transcriptional modifications mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect RNA metabolism. Evidence indicates that dysregulation m6A associated proteins contributes to glioblastoma (GBM) progression. However, function fat mass obesity-associated protein (FTO), an demethylase, has not been systematically comprehensively explored in GBM. Here, we found decreased FTO expression clinical specimens correlated with...