A5114444496- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Retinal Development and Disorders
- MicroRNA in disease regulation
- Consumer Behavior in Brand Consumption and Identification
- Digital Marketing and Social Media
- Bone and Dental Protein Studies
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Sulfur Compounds in Biology
- Hedgehog Signaling Pathway Studies
- Bacterial biofilms and quorum sensing
- Photoreceptor and optogenetics research
- Hydrogen's biological and therapeutic effects
- S100 Proteins and Annexins
- Media, Gender, and Advertising
- Bacterial Genetics and Biotechnology
- Biomedical Ethics and Regulation
- Protein Hydrolysis and Bioactive Peptides
- Heme Oxygenase-1 and Carbon Monoxide
- Immune Response and Inflammation
- Environmental DNA in Biodiversity Studies
- NF-κB Signaling Pathways
- Saffron Plant Research Studies
Shandong University
2019-2024
Smith-Kettlewell Eye Research Institute
2024
Stanford University
2024
Shanghai East Hospital
2024
Yangzhou University
2024
Shandong Management University
2022-2023
Minzu University of China
2022
Dalian Minzu University
2022
First Affiliated Hospital of Zhengzhou University
2021
Institute of Quality Standards and Testing Technology for Agro Products
2019
Our previous studies reported that L-Cysteine-derived H2S had remarkably neuroprotective effects against hypoxia-ischemic (HI) insult in neonatal animals. Here, we assessed one of the mechanisms protection exerted by L-Cysteine which stimulate microglial polarization to M2 phenotype and modulating complement expression after HI. treatment suppressed production inflammatory markers, while dramatically up-regulated levels anti-inflammatory cytokines damaged cortex. administration promoted...
Extracellular vesicles (EVs) from mesenchymal stromal cells (MSCs) have previously been shown to protect against brain injury caused by hypoxia-ischemia (HI). The neuroprotective effects found relate the anti-inflammatory of EVs. However, underlying mechanisms not determined. In this study, we induced oxygen-glucose deprivation in BV-2 (a microglia cell line), which mimics HI vitro, and that treatment with MSCs-EVs increased viability. was also reduce expression pro-inflammatory cytokines,...
Ischemic stroke is a common cause of mortality and severe disability in human currently lacks effective treatment. Neuronal activation neuroinflammation are the major two causes neuronal damage. However, little known about connection these phenomena. This study uses middle cerebral artery occlusion mouse model chemogenetic techniques to underlying mechanisms excitotoxicity after ischemic stroke. Chemogenetic inhibition activity ipsilesional M1 alleviates infarct area neuroinflammation,...
Retinitis pigmentosa (RP) is a complex spectrum of inherited retinal diseases marked by the gradual loss photoreceptor cells, ultimately leading to blindness. Among these, mutations in PDE6A, responsible for encoding cGMP-specific phosphodiesterase, stand out as pivotal autosomal recessive RP (RP43). Unfortunately, no effective therapy currently exists this specific form RP. However, recent advancements genome editing, such base editing (BE) and prime (PE), offer promising avenue precise...
Uncontrolled B-cell activation in systemic lupus erythematosus (SLE) induces autoantibody production and inflammation causes tissue damage. Basophils have been shown to promote B cell SLE; however, the molecular mechanisms involved remain nebulous. To elucidate role of basophilic exosomes explore associated SLE. We employed a multifaceted approach combining human studies animal models assessed effects basophil-derived on SLE patients by evaluating proliferation markers following exosome...
Cerebral ischemia is a common cerebrovascular condition which often induces neuronal apoptosis, leading to brain damage. The sonic hedgehog (Shh) signaling pathway has been reported be involved in ischemic stroke, but the underlying mechanisms have not fully elucidated. In present study, we demonstrated that expressions of Shh, Ptch, and Gli-1 were significantly downregulated at 24 h following oxygen-glucose deprivation (OGD) injury neurons vitro, effects associated with increasing numbers...
Summary Adulteration of goat meat with cheaper such as pork has been frequently found. Conventional PCR methods to distinguish from adulteration are qualitative, which easily produce false‐positive results due contamination but not adulteration. To address this problem, real‐time based on single‐copy housekeeping genes encoding replication protein A1 was developed for and pork. By calculating the Ct ratio meat/pork, content in a suspected could be deduced by good linear correlation ( R 2 =...
Lowe syndrome, a rare X-linked multisystem disorder presenting with major abnormalities in the eyes, kidneys, and central nervous system, is caused by mutations OCRL gene (NG_008638.1). Encoding an inositol polyphosphate 5-phosphatase, catalyzes hydrolysis of PI(4,5)P2 into PI4P. There are no effective targeted treatments for syndrome. Here, we demonstrate novel therapy syndrome patient fibroblasts using adenine base editor (ABE) that can efficiently correct pathogenic point mutations. We...
Induced pluripotent stem cells (iPSCs) reprogrammed from somatic into with most of the ESC (embryonic cell) characteristics show promise toward solving ethical problems currently facing cell research and eventually yield clinical grade for therapies regenerative medicine. In recent years, an increasing body suggests that chemical induction pluripotency (CIP) method can iPSCs in vitro, yet its application avian species remains unreported.
As an alternative protein product to animal meat, plant-based meat is considered play essential role in improving welfare and protecting the environment. However, why do a few consumers choose but others not? Despite increasing research on marketing, little known about psychological mechanism by which marketing affects consumers’ purchasing decisions. We utilize dual-system theory understand how social media of influences cognitive fluency, customer inspiration, perceived risk, purchase...
We previously found that osteopontin (OPN) played a role in hypoxia-ischemia (HI) brain damage. However, its underlying mechanism is still unknown. Bioinformatics analysis revealed the OPN protein was linked to lysosomal cathepsin B (CTSB) and galectin-3 (GAL-3) proteins after HI exposure. In present study, we tested hypothesis able play critical damage of microglia/macrophages following insult neonatal mice. The results showed expression enhanced, especially microglia/macrophages,...
Retinitis pigmentosa (RP) is characterized by degeneration of rod and cone photoreceptors that progresses to irreversible blindness. Now, there are no mutation-agnostic approaches treat RP. Here, we utilized a single adeno-associated virus (AAV)–based CRISPR activation system activate phosphodiesterase 6B (Pde6b) mitigate the severe in Pde6a nmf363 mice. We demonstrate transcriptional Pde6b can rescue loss , with preservation retinal structure, restoration electroretinography responses,...
Myotonic dystrophy (DM1) is mainly caused by abnormal number of the CTG repeat sequence DMPK gene. DM1 clinically manifests as progressive muscular atrophy and muscle weakness. Cataracts form in eyes some patients. We successfully induced skin fibroblasts from a patient with cataract turn pluripotent stem cells (iPSCs) using an unintegrated reprogramming approach. This cell line will provide reliable model for further studies on pathogenesis potential therapeutic targets DM1.