A5077833297- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Nuclear Receptors and Signaling
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Tuberous Sclerosis Complex Research
- RNA and protein synthesis mechanisms
- Neurological disorders and treatments
- MRI in cancer diagnosis
- Vagus Nerve Stimulation Research
- Advanced Electron Microscopy Techniques and Applications
- Meningioma and schwannoma management
- Immune cells in cancer
- Cancer Research and Treatments
- Circular RNAs in diseases
- Cancer Mechanisms and Therapy
- Brain Tumor Detection and Classification
Shandong University
2023
Qilu Hospital of Shandong University
2017-2023
Affiliated Hospital of Qingdao University
2020
Qingdao University
2020
Abstract Background Cullin-7 (CUL7) is a member of the DOC domain-containing cullin family and involved in regulation cell transformation. However, clinical significance, potential mechanism upstream regulators CUL7 malignant gliomas remain to be determined. Methods Expression level data information were obtained via Cancer Genome Atlas (TCGA) database, Chinese Glioma (CGGA) immunohistochemistry (IHC) western blot analysis. Gene set enrichment analysis (GSEA) was used explore molecular...
Abstract Background The immunosuppressive microenvironment in glioma induces immunotherapy resistance and is associated with poor prognosis. Glioma-associated mesenchymal stem cells (GA-MSCs) play an important role the formation of microenvironment, but mechanism still not clear. Results We found that GA-MSCs promoted expression CD73, ectonucleotidase drives maintenance by generating adenosine, on myeloid-derived suppressor (MDSCs) through exosomal miR-21 signaling. This process was similar...
Abstract Neuronal activity can drive progression of high-grade glioma by mediating mitogen production and neuron-glioma synaptic communications. Glioma stem cells (GSC) also play a significant role in progression, therapy resistance, recurrence glioma, which implicates potential cross-talk between neuronal GSC biology. Here, we manipulated using chemogenetics vitro vivo to study how it influences GSCs. supported glioblastoma (GBM) radioresistance through exosome-induced...
<p>Figure S5. The effect of A-NDEs on GSCs and GBM cells</p>
<p>Figure S6. A-NDEs promote the PMT of GSCs in vitro</p>
<p>Figure S7. A-NDEs do not change proliferation or apoptosis in GSCs</p>
<p>Figure S13. miR-184-3p promotes GSC PMT and radioresistance in vitro</p>
<p>Figure S9. Neuronal activity promote the PMT of GSCs in vivo</p>
<p>Figure S9. Neuronal activity promote the PMT of GSCs in vivo</p>
<p>Figure S2. Original western blots 2</p>
<p>Figure S11. A-NDEs reduced the m6A level in GSCs</p>
<p>Figure S4. Neuronal activity promotes exosomes release</p>
<p>Figure S8. A-NDEs promotes the radioresistance in GSCs</p>
<p>Figure S7. A-NDEs do not change proliferation or apoptosis in GSCs</p>
<p>Figure S5. The effect of A-NDEs on GSCs and GBM cells</p>
<p>Figure S11. A-NDEs reduced the m6A level in GSCs</p>
<p>Figure S2. Original western blots 2</p>
<p>Figure S8. A-NDEs promotes the radioresistance in GSCs</p>
<p>Figure S3. Original western blots 3</p>
<p>Figure S1. Original western blots 1</p>
<p>Figure S10. A-NDEs promote the PMT and radioresistance of GSCs in vivo</p>