A5071135776- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Bladder and Urothelial Cancer Treatments
- Immune cells in cancer
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Plant Stress Responses and Tolerance
- MicroRNA in disease regulation
- Photosynthetic Processes and Mechanisms
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Cancer-related gene regulation
- Plant responses to elevated CO2
- CNS Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Single-cell and spatial transcriptomics
- Angiogenesis and VEGF in Cancer
- Heat shock proteins research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
East China Normal University
2018-2025
Ministry of Natural Resources
2025
Inner Mongolia Autonomous Region Meteorological Bureau
2025
Inner Mongolia Normal University
2025
Xi'an University of Technology
2024-2025
Harbin Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Renji Hospital
2023-2024
University of Pennsylvania
2020-2024
Southern University of Science and Technology
2021-2024
Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis. Circular RNAs (circRNA), newly found type of endogenous noncoding RNA, characterized by high stability, abundance, conservation, have been shown to play an important role in pathophysiological processes TME remodelling various tumours.CircRNA sequencing analysis was performed explore circRNA expression profiles normal glioma tissues. The biological...
Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint blockade therapy, largely due extensive infiltration of immunosuppressive macrophages (Mϕs). Consistent with a pro-tumor role IL-6 in alternative Mϕs polarization, we here show that targeting by genetic ablation or pharmacological inhibition moderately improves T-cell into GBM and enhances mouse survival; however, does not synergize PD-1 CTLA-4 blockade. Interestingly, anti-IL-6 therapy reduces CD40...
Glioblastoma (GBM) is the most aggressive type of primary brain tumor and often resistant to current therapies. Tumor microenvironment-centered therapies may unleash new hope for GBM treatment. Therefore, an in-depth understanding tumor-stroma communication urgently needed identify promising therapeutic targets.We systematically analyzed single-cell RNA sequencing (scRNA-seq), bulk RNA-seq spatial scRNA-seq data from various human mice studies characterize network within microenvironment....
Resistance to temozolomide (TMZ) is a major obstacle preventing glioblastoma (GBM) recurrence after surgery. Although long noncoding RNAs (lncRNAs) play variety of roles in GBM, the lncRNAs that regulate TMZ resistance have not yet been clearly elucidated. This study aims identify may affect treatment sensitivity and explore novel therapeutic strategies overcome GBM.LncRNAs associated with were identified using Cancer Cell Line Encyclopedia (CCLE) Genomics Drug Sensitivity (GDSC) datasets....
T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This suppressive tumor microenvironment largely driven tumor-associated myeloid cells, including macrophages. Here, we report that toosendanin (TSN), a small-molecule compound, reprograms macrophages to enforce antitumor immunity in glioblastoma (GBM) mouse models. Our functional screen of genetically probed with chemical library identifies TSN...
Cancer immunity is subjected to spatiotemporal regulation by leukocyte interaction with neoplastic and stromal cells, contributing immune evasion immunotherapy resistance. Here, we identify a distinct mesenchymal-like population of endothelial cells (ECs) that form an immunosuppressive vascular niche in glioblastoma (GBM). We reveal spatially restricted, Twist1/SATB1-mediated sequential transcriptional activation mechanism, through which tumor ECs produce osteopontin promote macrophage (Mφ)...
Pulmonary fibrosis (PF) is a terminal change of lung disease that marked by damage to alveolar epithelial cells, abnormal proliferative transformation fibroblasts, excessive deposition extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, limited treatment effectiveness. More in-depth studies on the mechanisms PF are needed provide better options. The idea gut-lung axis has emerged as result comprehensive...
Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling from CSF means liquid glioma. However, few studies have focused on the function microRNAs in exosomes. In this study, we found that miR‐3184‐3p was enriched patients and downregulated after resection. We miR‐3184 facilitates progression two ways. On one hand, directly promotes proliferation, migration, invasion while inhibiting...
Background: Glioblastoma (GBM) is the most common primary brain malignancy and has high aggressiveness a poor prognosis.N6-methyladenosine (m6A) represents prevalent methylation modification of lncRNAs been shown to play important roles in pathophysiological processes tumors.However, distribution function m6A modifications GBM tissues have not fully revealed.Methods: The global depiction m6A-modified lncRNA expression patterns tumor was screened via high-throughput sequencing.Gain-and...
Abstract Background Parkinson’s disease (PD), a chronic and severe neurodegenerative disease, is pathologically characterized by the selective loss of nigrostriatal dopaminergic neurons. Dopamine (DA), neurotransmitter produced neurons, its metabolites can covalently modify proteins, dysregulation this process has been implicated in neuronal PD. However, much remains unknown about protein targets. Methods In present work, we designed synthesized dopamine probe (DA-P) to screen identify...
Interim 18F-FDG PET/CT is an effective predictor in patients with DLBCL, but the standard evaluating criteria were controversial. In this study, investigators tried to investigate whether liver SUVmax (SUVmax-liver)-based interpretation could improve accuracy of predicting outcomes, comparing Deauville five-point scale (5-PS) and reduction rate maximum standardized uptake value (ΔSUVmax) criteria. 119 patients, after two chemotherapy cycles (PET2) evaluated SUVmax-liver-based interpretation,...
The carbon emissions of three typical processes （AAO, MSBR, and oxidation ditch） were systematically analyzed from the perspective whole wastewater treatment process based on annual data eleven urban small medium-scale WWTPs in year 2022, effects different influent characteristics （TP, TN, BOD
Seeking effective improvement agent control measures to enhance the photosynthetic physiological traits and yield levels of spring maize is crucial for efficient green agriculture in arid regions. Therefore, this study was conducted clarify effects coupling agents under magnetoelectric activated water irrigation conditions on traits, grain nutrients, region northwest China. Field experiments were set up with three concentrations growth regulators: 400 times (G1), 500 (G2), 600 (G3), amounts...
As a national strategic development area, the Yellow River Basin (YRB) has seen progress in research on synergy efficiency of pollution reduction and carbon (SEPCR). However, there are still notable gaps. The theoretical framework for this area is lacking, leading to diverse inconsistent conclusions. Additionally, difficulties data collection processing, along with incomplete data, negatively affect accuracy findings. Current studies tend focus single aspects lack comprehensive systematic...
Introduction Ankle sprains are prevalent in basketball. This study sought to determine how midfoot wraps affect postural stability and ankle proprioception. Methods Twenty-two amateur basketball athletes performed three single-leg balance tests (static, head-elevated static, unstable foam pad) under four wrap conditions (no wrap, low, medium, high pressure), measures were taken using a force platform. Standing time, center of pressure dynamics, surface electromyographic the supporting leg...
Background An increasing number of RNA modification types other than N 6 -methyladenosine (m A) have been detected. Nonetheless, the probable functions modifications beyond m A in tumor microenvironment (TME), mesenchymal (MES) transition, immunotherapy, and drug sensitivity remain unclear. Methods We analyzed characteristics 32 non-m regulators 539 glioblastoma (GBM) patients TME cell infiltration MES transition patterns. Using principal component analysis, a epitranscriptome regulator...