A5038869496- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- ATP Synthase and ATPases Research
- Biotin and Related Studies
- RNA modifications and cancer
- Electrochemical sensors and biosensors
- Pancreatic and Hepatic Oncology Research
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Aquaculture disease management and microbiota
- Immune cells in cancer
- Pancreatic function and diabetes
- Salivary Gland Disorders and Functions
- Ferroptosis and cancer prognosis
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Renal cell carcinoma treatment
- Glaucoma and retinal disorders
- Kidney Stones and Urolithiasis Treatments
- FOXO transcription factor regulation
Stanford University
2020-2025
Stratford University
2022-2025
Huashan Hospital
2021-2024
Fudan University
2021-2024
Weatherford College
2023
Stanford Medicine
2021-2022
University of Chinese Academy of Sciences
2022
Ocean University of China
2016-2019
Hangzhou First People's Hospital
2017
Nanjing University of Chinese Medicine
2010
The lack of neuroprotective treatments for retinal ganglion cells (RGCs) and optic nerve (ON) is a central challenge glaucoma management. Emerging evidence suggests that redox factor NAD+ decline hallmark aging neurodegenerative diseases. Supplementation with precursors overexpression NMNAT1, the key enzyme in biosynthetic process, have significant effects. We first profile translatomes RGCs naive mice silicone oil-induced ocular hypertension (SOHU)/glaucoma by RiboTag mRNA sequencing....
T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic efficacy is limited by intratumoral immune suppression. This suppressive tumor microenvironment largely driven tumor-associated myeloid cells, including macrophages. Here, we report that toosendanin (TSN), a small-molecule compound, reprograms macrophages to enforce antitumor immunity in glioblastoma (GBM) mouse models. Our functional screen of genetically probed with chemical library identifies TSN...
Abstract The Warburg effect is the major metabolic hallmark of cancer. According to himself, consequence cell dedifferentiation. Therefore, reversing might be an approach restore differentiation in In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), activate respiration, which induced neural neuroblastoma cells. NEN treatment increased NAD+/NADH and pyruvate/lactate ratios also α-ketoglutarate/2-hydroxyglutarate (2-HG) ratio. Consequently, promoter CpG island...
Optic neuropathy is a group of optic nerve (ON) diseases with progressive degeneration ON and retinal ganglion cells (RGCs). The lack neuroprotective treatments central challenge for this leading cause irreversible blindness. SARM1 (sterile α TIR motif-containing protein 1) has intrinsic nicotinamide adenine dinucleotide (NAD+) hydrolase activity that causes axon by degrading axonal NAD+ significantly after activation injury. deletion in many, but not all, neurodegenerative disease models....
We aimed to develop a noninvasive radiomics approach reveal the m6A methylation status and predict survival outcomes therapeutic responses in patients. A total of 25 regulators were selected for further analysis, we confirmed that expression level genomic mutations rate significantly different between cancer normal tissues. Besides, constructed modification models explored immune infiltration biological pathway alteration among models. The subtypes identified this study can effectively...
As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic resistance stemming from this heterogeneity remains significant challenge. Here, we report that Vitamin D-resistant PDAC cells hijacked D signaling promote tumor progression, whereas epigenetic priming with glyceryl triacetate (GTA) and 5-Aza-2'-deoxycytidine (5-Aza) overcame shifted the transcriptomic phenotype of toward D-susceptible...
Loss of estrogen receptor (ER) pathway activity promotes breast cancer progression, yet how this occurs remains poorly understood. Here, we show that serine starvation, a metabolic stress often found in cancer, represses alpha (ERα) signaling by reprogramming glucose metabolism and epigenetics. Using isotope tracing time-resolved metabolomic analyses, demonstrate is required to maintain flux through glycolysis the TCA cycle support acetyl-CoA generation for histone acetylation. Consequently,...
Gossypol is known to be a polyphenolic compound toxic animals. However, its molecular targets are far from fully characterized. To evaluate the physiological and effects of gossypol, we chose turbot (Scophthalmus maximus L.), carnivorous fish, as our model species. Juvenile turbots (7.83 ± 0.02 g) were fed diets containing gradient levels gossypol at 0 (G0), 600 (G1), 1,200 (G2) mg/kg for 11 wk. After feeding trial, fish growth, body protein, fat contents significantly reduced in G2 group...
Background Tumor immunological heterogeneity potentially influences the prognostic disparities among patients with clear cell renal carcinoma (ccRCC); however, there is a lack of macroscopic imaging tools that can be used to predict immune-related gene expression in ccRCC. Methods A novel non-invasive radiogenomics biomarker was constructed for First, 520 ccRCC transcriptomic datasets from The Cancer Genome Atlas (TCGA) were analyzed using non-negative matrix decomposition (NMF) clustering...
Abstract When the electron transport chain (ETC) function is impaired, cancer cells rely on reductive carboxylation (RC) to convert α-ketoglutarate (αKG) citrate for macromolecular synthesis, thereby promoting tumor growth. Currently, there no viable therapy inhibit RC treatment. In this study, we demonstrate that mitochondrial uncoupler treatment effectively inhibits in cells. Mitochondrial activates ETC and increases NAD+/NADH ratio. Using U–13C-glutamine 1–13C-glutamine tracers, show...
Relapse continues to limit survival for patients with B-cell acute lymphoblastic leukemia (B-ALL). Previous studies have independently implicated activation of developmental signaling pathways and increased glucose consumption chemo-resistance relapse risk. Here, we connect these observations, demonstrating that B-ALL cells active signaling, defined by high expression phosphorylated ribosomal protein S6 ("pS6+ cells"), are metabolically unique dependent. Isotope tracing metabolic flux...
Abstract Glutamine reprogramming is a hallmark feature of clear cell renal carcinoma (ccRCC). However, the regulation glutamine in ccRCC incompletely understood. Here we demonstrate that RNA demethylase enzyme, FTO, promotes cells to support growth and survival. Genetic pharmacologic inhibition FTO reduced glutamine-derived reductive carboxylation, de novo pyrimidine synthesis glutathione biosynthesis. resulted increased DNA damage survival were rescued by administration pyrimidines...
Several studies have found that pathological imbalance of alterative splicing (AS) events is associated with cancer susceptibility. carcinogenicity. Nevertheless, the relationship between heritable variation in AS and carcinogenicity has not been extensively explored. Here, we downloaded event signatures, transcriptome profiles, matched clinical information from The Cancer Genome Atlas (TCGA) database, identified prognostic AS-related via conducting univariate Cox regression algorism....
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand aquaculture industry. In present study, modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, metabolic pathways were systematically examined in primary muscle cells turbot (Scophthalmus maximus). PA was found to stimulate proliferation G1/S phase transition through activation target rapamycin (TOR) signaling pathway. The expression myogenic...
Abstract Adult salivary stem/progenitor cells (SSPC) have an intrinsic property to self-renew in order maintain tissue architecture and homeostasis. glands been documented harbor SSPC, which shown play a vital role the regeneration of glandular structures postradiation damage. We previously demonstrated that activation aldehyde dehydrogenase 3A1 (ALDH3A1) after radiation reduced accumulation leading less apoptosis improved function. subsequently found sustained pharmacological ALDH3A1 is...
Abstract As a highly heterogeneous tumor, pancreatic ductal adenocarcinoma (PDAC) exhibits non-uniform responses to therapies across subtypes. Overcoming therapeutic resistance due tumor heterogeneity in PDAC remains challenge. Here, we report that Vitamin D-resistant cells hijacked D signaling promote progression, whereas epigenetic priming with glyceryl triacetate (GTA) and 5-Aza-2′-deoxycytidine (5-Aza) overcame shifted the transcriptomic phenotype of toward D-susceptible state....
Neuroblastoma is a leading cause of death in childhood cancer cases. Unlike adult malignancies, which typically develop from aged cells through accumulated damage and mutagenesis, neuroblastoma originates neural crest with disrupted differentiation. This distinct feature provides novel therapeutic opportunities beyond conventional cytotoxic methods. Previously, we reported that the mitochondrial uncoupler NEN (niclosamide ethanolamine) activated mitochondria respiration to reprogram...
<p>S4. Mitochondrial uncoupler NEN inhibits reductive carboxylation under hypoxia.</p>