A5073073689- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Gene expression and cancer classification
- Salivary Gland Disorders and Functions
- Single-cell and spatial transcriptomics
- Cancer, Hypoxia, and Metabolism
- Childhood Cancer Survivors' Quality of Life
- Medical Imaging and Analysis
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- Brain Tumor Detection and Classification
- Silk-based biomaterials and applications
- Neuroblastoma Research and Treatments
- HER2/EGFR in Cancer Research
- Salivary Gland Tumors Diagnosis and Treatment
- RNA Research and Splicing
- Network Security and Intrusion Detection
- Bullying, Victimization, and Aggression
- Cancer survivorship and care
- Genomic variations and chromosomal abnormalities
Chinese University of Hong Kong, Shenzhen
2025
Network Technologies (United States)
2025
Shenzhen Center for Disease Control and Prevention
2025
Zunyi Medical University
2025
Xijing Hospital
2024
Stanford University
2018-2023
Stanford Medicine
2021-2022
Stanford Health Care
2022
Arista (United States)
2020
Illumina (United States)
2016-2017
Immune checkpoint inhibitors (ICIs), although promising, have variable benefit in head and neck cancer (HNC). We noted that tumor galectin-1 (Gal1) levels were inversely correlated with treatment response survival patients HNC who treated ICIs. Using multiple mouse models, we show tumor-secreted Gal1 mediates immune evasion by preventing T cell migration into the tumor. Mechanistically, reprograms endothelium to upregulate cell-surface programmed death ligand 1 (PD-L1) galectin-9. genetic...
This study aimed to analyse the temporal and spatial trends in burden of anxiety disorders major depressive disorder related bullying victimisation on global, regional country scales.Data were from 2019 Global Burden Disease (GBD) Study. We assessed global disability-adjusted life years (DALYs, per 100 000 population) attributable by age, sex geographical location. The percentage changes age-standardised rates DALYs used quantify trends, annual rate across 204 countries territories present...
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing. Disease stage and smoking history are often used in current clinical trials to select patients for deintensification therapy, but these features lack sufficient accuracy predicting disease relapse. Our purpose was develop an imaging signature assess early response predict outcomes OPSCC. Methods: We retrospectively analyzed 162 OPSCC treated with concurrent chemoradiotherapy, equally divided into...
Prognostic biomarkers that can reliably predict early disease progression of non-small cell lung cancer (NSCLC) are needed for identifying those patients at high risk progression, who may benefit from more intensive treatment. In this work, we aimed to identify an imaging signature predicting progression-free survival (PFS) locally advanced NSCLC. Methods: This retrospective study included 82 with stage III NSCLC treated definitive chemoradiotherapy whom both baseline and mid-treatment...
Stereotactic ablative radiotherapy (SABR) is used for treating lung tumors but can cause toxic effects, including life-threatening damage to central structures. Retrospective data suggested that small up 10 cm3 in volume be well controlled with a biologically effective dose less than 100 Gy.
Chronic liver disease represents a significant health challenge worldwide and accurate prognostic evaluations are essential for personalized treatment plans. Recent evidence suggests that integrating multimodal data, such as computed tomography imaging, radiomic features, clinical information, can provide more comprehensive information. However, modalities have an inherent heterogeneity, incorporating additional may exacerbate the challenges of heterogeneous data fusion. Moreover, existing...
Abstract Background Metabolic response assessment for oropharyngeal squamous cell carcinoma (OPSCC) aids in identifying locoregional persistence/recurrence (LRR). The Hopkins Criteria are a standardized qualitative system using posttreatment FDG‐PET/CT. Methods We conducted retrospective cohort study of patients with node‐positive OPSCC treated definitive (chemo)radiotherapy. assessed performance LRR, then developed and validated competing‐risks model. Results Between 2004 2018, 259 were...
ABSTRACT Advances in multiplexed situ imaging are revealing important insights spatial biology. However, cell type identification remains a major challenge analysis, with most existing methods involving substantial manual assessment and subjective decisions for thousands of cells. We propose novel machine learning algorithm, CELESTA, which uses both cell’s protein expression information to identify individual demonstrate the performance CELESTA on immunofluorescence images colorectal cancer...
Abstract Expanding the paradigm of solid tumor profiling from single-gene testing to comprehensive panels presents many challenges. One such challenges is ability these detect genetic alterations FFPE samples, where DNA low abundance and often heavily compromised. Despite challenges, next-generation sequencing (NGS) offers assess multiple variants simultaneously in an ever-expanding list relevant genes. To that end, Illumina developed a comprehensive, hybrid capture-based NGS assay targeting...
Abstract Recent studies have highlighted the importance of gene fusions and splice variants in solid tumor profiling1. Next-generation sequencing can be an effective means detecting these alterations FFPE samples using RNA rather than DNA, as a single chimeric transcript could result from numerous DNA2. To that end, Illumina developed TruSight® Tumor 1703, comprehensive, hybrid capture-based NGS assay targeting 170 key cancer genes. Along with DNA workflow, includes workflow for...
Abstract Adult salivary stem/progenitor cells (SSPC) have an intrinsic property to self-renew in order maintain tissue architecture and homeostasis. glands been documented harbor SSPC, which shown play a vital role the regeneration of glandular structures postradiation damage. We previously demonstrated that activation aldehyde dehydrogenase 3A1 (ALDH3A1) after radiation reduced accumulation leading less apoptosis improved function. subsequently found sustained pharmacological ALDH3A1 is...
Glial cell-derived neurotrophic factor (GDNF) is reported to promote the survival of neurons and salivary gland regeneration after radiation damage. This study investigated effect GDNF on cell migration, growth, response in preclinical models head neck squamous carcinoma (HNSCC) correlated expression treatment outcomes HNSCC patients. Our ultimate goal determine whether systemic administration at high dose safe for management hyposalivation or xerostomia Three HPV-positive three HPV-negative...
Abstract Solid tumor profiling assays need to deliver accurate and consistent results in the face of decreased quality quantity nucleic acids extracted from FFPE samples. Understanding performance a particular solid assay with tissue is critical, but limited non-renewable samples available most assay-developers, sample number used understand this can be small. TruSight® Tumor 1701 an Illumina-developed comprehensive panel targeting 170 genes using DNA RNA In order confirm robustness tissue,...
To retrospectively analyze the treatment status of tyrosine kinase inhibitors (TKI) in newly diagnosed patients with chronic myeloid leukemia (CML) China.