A5100457918- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Nerve injury and regeneration
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Cancer, Lipids, and Metabolism
- Axon Guidance and Neuronal Signaling
- Intensive Care Unit Cognitive Disorders
- Vestibular and auditory disorders
- Liver Disease Diagnosis and Treatment
- Electroconvulsive Therapy Studies
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Takotsubo Cardiomyopathy and Associated Phenomena
- Aortic aneurysm repair treatments
- Acoustic Wave Phenomena Research
- Ultrasound in Clinical Applications
- Health and Medical Research Impacts
- Connexins and lens biology
- Hearing Loss and Rehabilitation
- Spinal Dysraphism and Malformations
- Histone Deacetylase Inhibitors Research
Nanjing University of Chinese Medicine
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Air Force Medical University
2025
Sun Yat-sen University
2019-2024
Third Affiliated Hospital of Sun Yat-sen University
2019-2024
University of California, Los Angeles
2024
Harbin Medical University
2023
Indiana University Bloomington
2023
Vanke (China)
2023
Stomatology Hospital
2022
Techniques for fast noninvasive control of neuronal excitability will be major importance analyzing and understanding networks animal behavior. To develop these tools we demonstrated that two light-activated signaling proteins, vertebrate rat rhodopsin 4 (RO4) the green algae channelrhodospin 2 (ChR2), could used to modulate synaptic transmission. Vertebrate couples Gi/o, pertussis toxin-sensitive pathway allow modulation G protein-gated inward rectifying potassium channels voltage-gated...
Abstract Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability timely administrate therapeutics precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal rapid on-demand disease management. Through integration metamaterials, compact therapeutic patch is integrated...
Acyl-CoA synthetase long chain family member 4 (ACSL4) is closely related to tumor genesis and development in certain tissues. However, the function of ACSL4 early brain injury (EBI) caused by subarachnoid hemorrhage (SAH) unclear. In this study, we investigated expression patterns role SAH post-SAH EBI using a rat model SAH.The was induced autologous blood injection into prechiasmatic cistern rats. We also used two specific inhibitors ferroptosis (Ferrostatin-1 Liproxstatin-1) investigate...
Peripheral nerve damage causes neuroinflammation, which plays a critical role in establishing and maintaining neuropathic pain (NeP). The mechanisms contributing to neuroinflammation remain poorly elucidated, pharmacological strategies for NeP are limited. Thus, this study, we planned explore the possible link between astrocyte senescence disorders following chronic sciatic injury.An animal model was established by inducing constrictive injury (CCI) adult rats. A senolytic drug combination...
Abdominal aortic aneurysm (AAA) is one of the most dangerous types vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders AAA. However, evidence a causal relationship blood metabolites AAA still lacking at present. Using Mendelian randomization (MR), we assessed 1,400 serum The inverse variance weighted method (IVW), median, MR-Egger regression, simple mode,...
Methamphetamine (METH) is a commonly abused psychostimulant with high addictive nature. The paraventricular nucleus of thalamus (PVT), key for arousal, has attracted much attention in the reward process substance use. However, at which stage dose PVT encode process? How to reduce side-effects modulating on wakefulness during treatment use? These issues remain unclear. goal current study explore role and glutamatergic projections from medial prefrontal cortex (mPFC) METH. Methods: Here,...
<title>Abstract</title> Ionizing radiation is effective in combating cancer but inflicts severe damage on the oral mucosa. The mechanisms behind this remain unclear, and current treatment modalities are primarily palliative. This study revealed that ferroptosis predominant reason for oral-radiation depletion of mucosal epithelial cells. More importantly, compensatory activated organism during early stage after exposure. These arise from metabolic support provided by fibroblasts. In...
C-Type Lectin Domain Family 3 Member B (CLEC3B) encodes proteins associated with tumor invasion and metastasis. However, the interrelation between CLEC3B gene expression, immunity, prognosis of patients hepatocellular carcinoma (HCC) is unclear. This study was conducted to investigate prognostic potential its association tissue infiltration markers. expression examined using TIMER Oncomine databases, assessed GEPIA Kaplan–Meier plotter databases. The relationship immune cell biomarkers...
Schwann cells (SCs)-based nerve guidance conduits (NGCs) is a promising strategy for repairing long-gap peripheral injury (PNI). But the number of SCs limited as terminally differentiated cells. Matrix stiffness able to direct cell fate stem And nerve-special (NSS) may contribute converting into SCs. However, potential mechanisms remain uncertain. The present study aimed elucidate whether given NSS was promote mesenchymal (MSCs) trans-differentiating cell-like (SCLCs), facilitating...
Postoperative sore throat is a frequent adverse event after double-lumen endobronchial tube (DLT) intubation. The aim of this study was to investigate whether esketamine gargle has preventive effect on the incidence postoperative in patients undergoing DLT intubation.This trial included 140 elective thoracic surgery at third affiliated hospital Sun Yat-Sen University. Patients were randomly allocated into following two groups 70 each: control group, gargling with saline 30 mL, and an...
Long-term potentiation and depression, inferred from analysis on brain slices, are considered the cellular processes underlying learning memory formation. They have not so far been demonstrated in human stem cell-derived neurons. By expressing channelrhodopsin hESCs-derived glutamate neurons co-culturing them with GABA neurons, we found that blue light stimulation increased frequency of miniature excitatory postsynaptic currents (mEPSCs) decreased ratio paired pulse facilitation (PPF)...
Cognitive impairment is a complication that most frequently happens in patients with chronic neuropathic pain and has limited effective therapy. The aim of this study was to explore the effects curcumin on cognitive deficit rats peripheral nerve injury induced-neuropathic pain.The rat model constructed using constriction (CCI). (60 mg/kg) or vehicle intraperitoneally administered once day, beginning at 14th day after surgery continued for 14 consecutive days. nociceptive threshold tests were...
Abstract Bone marrow‐derived mesenchymal stem cells (BMSCs) show a good property for pain treatment by modulating inflammatory response. However, the underlying therapeutic effect and related mechanism of BMSCs on remain unclear. Therefore, we explored function potential performing in complete Freund's adjuvant (CFA)‐induced model this study. Here, were injected into CFA‐treated rats, used behavioural tests to evaluate changes hypersensitivity. High‐throughput sequencing was screen out hub...
General electric devices and ventilation systems are known to generate low frequency noise (LFN) with frequencies of less than 100 Hz. Previous studies showed that exposure LFN caused impairments balance in humans mice during adulthood. On the other hand, a previous study levels neonatal intensive care unit (NICU) were greater those general home or office environments. Therefore, it is possible neonates have potential risk be exposed NICU. However, remains unclear mice. In this study, male...
Brown adipocytes are rich in mitochondria and linked to the body's blood fat levels obesity. MiR-92a is negatively correlated with activity of brown adipocytes. This study aimed explore mechanism miR-92a on The expression C2C12 cell was detected by a quantitative real-time-polymerase chain reaction (qRT-PCR). cells were induced direct target gene determined using dual-luciferase reporter assay. treated isoprenaline (Iso) transfected inhibitor siSMAD7. heat-producing genes adipose...
Neuropathic pain is a common, debilitating clinical issue. Here, the weighted gene co-expression network analysis (WGCNA) was used to identify specific modules and hub genes that are related neuropathic pain. The microarray dataset of rat model induced by tibial nerve transection (TNT), including dorsal root ganglion (DRG) tissues from TNT (n=7) sham (n=8) rats, downloaded ArrayExpress database (E-MTAB-2260). were identified WGCNA package. protein-protein interaction (PPI) constructed, node...