A5102797597- Neonatal and fetal brain pathology
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Thermal Regulation in Medicine
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Genetics and Neurodevelopmental Disorders
- CRISPR and Genetic Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal Respiratory Health Research
- Neuroscience and Neural Engineering
- Fetal and Pediatric Neurological Disorders
- Zebrafish Biomedical Research Applications
- Down syndrome and intellectual disability research
- Autism Spectrum Disorder Research
- Renal and related cancers
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Nerve injury and regeneration
- Ferroptosis and cancer prognosis
- Silk-based biomaterials and applications
- Alzheimer's disease research and treatments
- 3D Printing in Biomedical Research
- Genetic and Kidney Cyst Diseases
Fudan University
2013-2025
Guangzhou University of Chinese Medicine
2022-2025
State Key Laboratory of Medical Neurobiology
2022-2024
The First People's Hospital of Zhaoqing
2023
Wuhan University
2022
Children's Hospital of Fudan University
2009-2022
Guangdong Provincial People's Hospital
2020-2022
Hubei University
2022
Nanjing University of Aeronautics and Astronautics
2021
Stem Cell Institute
2021
Abstract Electrospun scaffolds play important roles in the fields of regenerative medicine and vascular tissue engineering. The aim research described here was to develop a scaffold that mimics structural functional properties natural scaffolding. mechanical artificial represent key issue for successful transplantation small diameter engineering blood vessels. We blended silk fibroin (SF) fibrin fabricate composite using electrospinning overcome shortcomings with respect its properties....
Human pluripotent stem cell-based (hPSC-based) replacement therapy holds great promise for the treatment of Parkinson's disease (PD). However, heterogeneity hPSC-derived donor cells and low yield midbrain dopaminergic (mDA) neurons after transplantation hinder its broad clinical application. Here, we have characterized single-cell molecular landscape during mDA neuron differentiation. We found that this process recapitulated development multiple but adjacent fetal brain regions including...
Periventricular leukomalacia (PVL) is a common ischemic brain injury in premature infants for which there no effective treatment. The objective of this study was to determine whether transplanted mouse oligodendrocyte progenitor cells (OPCs) have neuroprotective effects rat model PVL. Hypoxia-ischemia (HI) induced 3-day-old pups by left carotid artery ligation, followed exposure 6% oxygen 2.5 h. Animals were assigned OPC transplantation or sham control groups and injected with OPCs PBS,...
The cell lineages across developmental stages remain to be elucidated. Here, we developed single-cell split barcoding (SISBAR) that allows clonal tracking of transcriptomes in an vitro model human ventral midbrain-hindbrain differentiation. We "potential-spective" and "origin-spective" analyses investigate the cross-stage lineage relationships mapped a multi-level landscape depicting whole differentiation process. uncovered many previously uncharacterized converging diverging trajectories....
Quercetin (Que), one of the flavonoids, exerts numerous actions on central nervous system. However, roles and underlying mechanism Que in locomotor function recovery axonal regeneration following spinal cord injury (SCI) have not been fully elucidated. A rat model was established at T10 using modified Allen's method. The results our study indicated that Basso, Beattie Bresnahan (BBB) scores were significantly higher after treatment. Additionally, administration cut down latency somatosensory...
Neonatal brain development constitutes a critical period of structural and functional maturation underpinning sensory, motor, cognitive capacities. The glymphatic system-a cerebral waste clearance network-remains poorly understood in neonates. We investigated non-invasive magnetic resonance imaging (MRI) biomarkers system their developmental correlates In 117 neonates undergoing high-resolution T1-weighted diffusion MRI, we quantified two metrics: (1) tensor along the perivascular space...
Neural stem cell (NSC) proliferation and differentiation are required to replace neurons damaged or lost after hypoxic-ischemic events recover brain function. Periostin (POSTN), a novel matricellular protein, plays pivotal roles in the survival, migration, regeneration of various types, but its function NSCs neonatal rodent is still unknown. The purpose this study was investigate role POSTN following hypoxia-ischemia (HI). We found that mRNA levels significantly increased differentiating...
Long-term potentiation and depression, inferred from analysis on brain slices, are considered the cellular processes underlying learning memory formation. They have not so far been demonstrated in human stem cell-derived neurons. By expressing channelrhodopsin hESCs-derived glutamate neurons co-culturing them with GABA neurons, we found that blue light stimulation increased frequency of miniature excitatory postsynaptic currents (mEPSCs) decreased ratio paired pulse facilitation (PPF)...
Previous studies have demonstrated that ischemic stroke increases β-amyloid (Aβ) production by increasing β-secretase (BACE1) through activation of caspase-3, and stimulates generation mutant ubiquitin (UBB +1 ) in rat brains. In this study, we examined whether caspase-3 participates the regulation UBB -mediated BACE1 stability injured The results showed activated caspase-3-immunopositive-stained cells were time dependently increased ipsilateral striatum brains after middle cerebral artery...
Hypothermia is known to improve neurological recovery of animals and humans exposed hypoxic-ischemic (HI) injury. However, the underlying mechanisms neuroprotective effects hypothermia are only partially understood, including decreased excitotoxicity apoptosis, suppressed inflammation. There few studies about hypothermic on axonal injury oligodendrocyte (OL) lineage degeneration, which important components neonatal brain injuries that cause cognitive disability. We hypothesized mild would...
Abstract Perinatal hypoxic–ischaemic encephalopathy is the leading cause of neonatal death and permanent neurological deficits, while basal ganglia one major nuclei that selectively greatly affected in brains patients, especially severe cases. Human embryonic stem cell-derived neurons have shown great potential different types brain disorders adults. However, it remains unknown whether how grafted human can repair immature with encephalopathy. Here, by administrating genetically labelled...