A5101780235- Retinal Development and Disorders
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Retinal Diseases and Treatments
- Developmental Biology and Gene Regulation
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Glaucoma and retinal disorders
- MicroRNA in disease regulation
- RNA Research and Splicing
- Long-Term Effects of COVID-19
- Cellular transport and secretion
- Cancer Mechanisms and Therapy
- Connective tissue disorders research
- Circular RNAs in diseases
- Sphingolipid Metabolism and Signaling
- Retinal and Macular Surgery
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Epilepsy research and treatment
- Cancer-related molecular mechanisms research
- Web Data Mining and Analysis
- Ocular Disorders and Treatments
- Ubiquitin and proteasome pathways
Sun Yat-sen University
2012-2025
Children’s Hospital of Fudan University Xiamen Branch
2024-2025
Fujian Agriculture and Forestry University
2024-2025
Xiamen University
2025
Zhongshan Hospital of Xiamen University
2025
Zhejiang Chinese Medical University
2025
Hunan Normal University
2020-2024
Hunan Provincial People's Hospital
2015-2024
Fujian Medical University
2008-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2024
Although the molecular mechanisms of TNF signaling have been largely elucidated, principle that regulates balance life and death is still unknown. We report here domain kinase RIP, a key component complex, was cleaved by Caspase-8 in TNF-induced apoptosis. The cleavage site mapped to aspartic acid at position 324 RIP. demonstrated RIP resulted blockage NF-kappaB activation. RIPc, one products, enhanced interaction between TRADD FADD/MORT1 increased cells' sensitivity TNF. Most importantly,...
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 histone H3 (H3K27) and regulates cell proliferation differentiation during embryonic development. Recently, hot-spot mutations were identified in diffused large B-cell lymphomas follicular lymphomas. To investigate if tumor growth dependent on activity Ezh2, we developed a potent selective small molecule inhibitor, EI1, inhibits...
Tumors put in a vulnerable position Cancer cells often display alterations metabolism that help fuel their growth. Such metabolic “rewiring” may also work against the cancer cells, however, by creating new vulnerabilities can be exploited therapeutically. A variety of human tumors show changes methionine caused loss gene coding for 5-methylthioadenosine phosphorylase (MTAP). Mavrakis et al. and Kryukov found MTAP renders cell lines sensitive to growth inhibition compounds suppress activity...
Abstract PRMT3 catalyzes the asymmetric dimethylation of arginine residues various proteins. It is essential for maturation ribosomes, may have a role in lipogenesis, and implicated several diseases. A potent, selective, cell‐active inhibitor would be valuable tool further investigating biology. Here we report discovery first chemical probe, SGC707, by structure‐based optimization allosteric inhibitors reported previously, thorough characterization this probe biochemical, biophysical,...
Tumor metastasis occurs naturally in pancreatic cancer, and the efficacy of chemotherapy is usually poor. Precision medicine, combining downregulation target genes with drugs, expected to improve therapeutic effects. Therefore, we developed a combined therapy micro RNA ‐21 antisense oligonucleotides ( ASO ‐miR‐21) gemcitabine (Gem) using targeted co‐delivery nanoparticle NP ) carrier investigated synergistic inhibitory effects on cancer cells growth. Polyethylene...
Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, biogenesis, biofunction and mechanism triple-negative (TNBC) are largely unknown.High-throughput RNA sequencing was applied to identify dysregulated TNBCs paired normal tissues. pulldown luciferase assays were performed investigate interaction between circular CD44 (circCD44, also annotated as hsa_circ_0021735) miR-502-5p. RIP used circCD44 IGF2BP2. Cell viability, colony formation,...
Summary In eukaryotes, the retromer complex plays a crucial role in sorting and retrograde transport of cargo proteins from endosomes to trans ‐Golgi network (TGN). Despite its importance, molecular details this intracellular process remain unclear. Here, we have identified Golgi‐associated protein (GARP) as mediator vesicle that facilitates recruitment TGN exert functions. The GARP is mainly localized where it interacts with complex. This interaction evolutionarily conserved across species....
PAX6 is a master regulatory gene involved in neuronal cell fate specification. It also plays critical role early eye field and subsequent limbal stem (LSC) determination during development. Defects Pax6 cause aniridia LSC deficiency humans the Sey (Small eye) phenotype mice (Massé, K., Bhamra, S., Eason, R., Dale, N., Jones, E. A. (2007) Nature 449, 1058-1062). However, how specifies corneal fates development not well understood. Here, we show that expressed primitive cup later tissue...
Polycomb repressive complex 2 (PRC2), a histone H3 lysine 27 methyltransferase, plays key role in gene regulation and is known epigenetics drug target for cancer therapy. The WD40 domain-containing protein EED the regulatory subunit of PRC2. It binds to tri-methylated (H3K27me3), through which stimulates activity PRC2 allosterically. Recently, we disclosed novel inhibitor EED226 K27me3-pocket on showed strong antitumor xenograft mice model. Here, further report identification validation four...
Brain metastasis (BM) is common in patients with non-small cell lung cancer (NSCLC) and associated a poor prognosis. Ceramide synthase 1 (CERS1) participates malignancy development, but its potential role NSCLC BM remains unclear. This study aimed to explore the physiological effects molecular mechanism of CERS1 BM. expression was evaluated tissues lines, roles were subsequently explored vivo vitro. Mass spectrometry co-immunoprecipitation performed CERS1-interacting proteins. The signaling...
Abstract Background Ceramide metabolism is crucial in the progress of brain metastasis (BM). However, it remains unexplored whether targeting ceramide may arrest BM. Methods RNA sequencing was applied to screen different genes primary and metastatic foci whole-exome (WES) seek abnormal pathway BM + BM-patients. Cellular arrays were analyze permeability blood–brain barrier (BBB) activation or inhibition pathway. Database Co-Immunoprecipitation (Co-IP) assay adopted verify protein–protein...
To examine the influence of HOXD10 on metabolism and growth colon carcinoma cells by suppressing RHOC/AKT/MAPK pathway. Thirty-seven paired cancer its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed. Chip Analysis Methylation Pipeline (ChAMP) analysis was employed for differential methylated points (DMPs) methylation regions (DMRs) screening. mRNA expression DNA levels detected RT-PCR. Cell proliferation, migration, invasion apoptosis respectively measured MTT assay,...
The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for breast cancer has incorporated tumor grade, estrogen receptor, progesterone and human epidermal growth factor receptor 2 status as biologic factors reflecting prognosis. purpose this study was to compare 7th AJCC prognostic impact.Primary patients diagnosed from 2010 2014 were identified using Surveillance, Epidemiology End Results 18 registries research database. Breast cancer-specific survival (BCSS)...
Abstract SNAREs (soluble N ‐ethylmaleimide‐sensitive factor attachment protein receptors) facilitate docking and fusion of vesicles with their target membranes, playing a crucial role in vesicle trafficking exocytosis. However, the spatial assembly roles plasma membrane (PM)‐associated phytopathogen development pathogenicity are not clearly understood. In this study, we analysed molecular mechanisms PM‐associated SNARE complexes banana Fusarium wilt fungus oxysporum f. sp. cubense tropical...
LSD1 (Lysine Specific Demethylase1)/KDM1A Demethylase 1A), a flavin adenine dinucleotide (FAD)-dependent histone H3K4/K9 demethylase, sustains oncogenic potential of leukemia stem cells in primary human cells. However, the pro-differentiation and anti-proliferation effects inhibition acute myeloid (AML) are not yet fully understood. Here, we report that small hairpin RNA (shRNA) mediated causes remarkable transcriptional activation lineage marker genes (CD11b/ITGAM CD86), reduction cell...
Pharmacologically-induced liver injury from N-acetyl-p-aminophenol (APAP) overdose has become a leading cause of acute failure. Extensive research elucidated the relationship between intestinal microbiota and pathophysiology diseases. The growing body evidence supporting beneficial effects probiotics, coupled with their established safety profile, led to widespread adoption in clinical practice. Among these, Bifidobacterium bifidum garnered substantial attention due its potential...
Aim To explore the effects of full course care with an intelligent interactive system on growth, neurodevelopment and follow up adherence very low birth weight infants (VLBW), as well parental satisfaction. Methods The preterm admitted between January 2022 December were designated experimental group, while those from 2021 to constituted control group. group received a through system, whereas inpatient follow-up primary clinic nurses, respectively. We compared two groups' satisfaction at...
Stargardt disease (STGD1), the most common retinal dystrophy caused by pathogenic variants of biallelic ABCA4 gene, results in irreversible vision loss. This cross-sectional case series study analyzes 18 unrelated (STGD1) patients from southeast China, examining clinical and genetic features. Ophthalmological assessments included BCVA, ophthalmoscopy, fundus photography, autofluorescence, with ultra-widefield OCT angiography carried out on one patient. Genetic testing uses targeted exome...
The COVID-19 pandemic has raised significant concerns regarding its impact on the central nervous system, including brain. While effects adult populations are well documented, less is known about implications for pediatric populations. This study investigates alterations in cortical metrics and structural covariance networks (SCNs) based Local Gyrification Index (LGI) children with mild COVID-19, alongside changes non-invasive MRI proxies related to glymphatic function. We enrolled 19 22...