A5100697837- RNA modifications and cancer
- Ion Channels and Receptors
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Nuclear Receptors and Signaling
- Cancer therapeutics and mechanisms
- Enzyme Structure and Function
- Mitochondrial Function and Pathology
- Peptidase Inhibition and Analysis
- Aquaculture Nutrition and Growth
- Genomics and Chromatin Dynamics
- Wnt/β-catenin signaling in development and cancer
- Adenosine and Purinergic Signaling
- Natural product bioactivities and synthesis
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Protein Kinase Regulation and GTPase Signaling
- CRISPR and Genetic Engineering
- Animal Genetics and Reproduction
Huazhong University of Science and Technology
2023-2025
Tongji Hospital
2023-2025
Boston University
2021-2025
Air Force Medical University
2023-2025
Shanghai Jiao Tong University
2011-2024
Shanghai Sixth People's Hospital
2024
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital Zhejiang University
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2024
Zhengzhou University
2022-2024
Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance between catabolism anabolism extracellular matrix (ECM), is most common age-related degenerative joint disease worldwide. As sleep has been found to be beneficial for cartilage repair, circular RNAs (circRNAs) have demonstrated involved in pathogenesis OA, we performed RNA sequencing (RNA-seq), circRNA3503 was significantly increased after melatonin (MT)-induced cell sleep. Upregulation expression...
Abstract The endoplasmic reticulum (ER) network consists of tubules with high membrane curvature in cross-section, generated by the reticulons and REEPs. These proteins have two pairs trans-membrane (TM) segments, followed an amphipathic helix (APH), but how they induce is poorly understood. Here, we show that REEPs form homodimers interaction within membrane. When overexpressed or reconstituted at concentrations phospholipids, cause extreme through their TMs, generating lipoprotein...
Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases. Most peroxisomal proteins imported from the cytosol in a folded state by soluble receptor PEX5. How cargo crosses membrane is unknown. Here, we show that import similar to nuclear transport. The protein PEX13 contains conserved tyrosine (Y)- and glycine (G)-rich YG domain, which forms selective phase resembling formed phenylalanine-glycine (FG) repeats within pores. resides two orientations oligomerize...
Abstract Cartilage defects resulting from injury or degeneration are a common clinical problem, and due to its avascular nature, articular cartilage has poor self‐healing capacity. Three‐dimensional (3D) bioprinting attracted great attention in tissue engineering. Melatonin (MT), hormone mainly secreted at night, plays an important role repair. Small extracellular vesicles (sEV) considered ideal drug delivery vehicles MT‐sEV (sleep‐related sEV) have the potential ability promote...
Ubiquitination has been demonstrated to play a pivotal role in multiple biological functions, which include cell growth, proliferation, apoptosis, DNA damage response, innate immune and neuronal degeneration. Although the of ubiquitination targeting proteins for proteasome-dependent degradation have extensively studied well-characterized, critical nonproteaolytic functions ubiquitination, such as protein trafficking kinase activation, involved survival cancer development, just start emerge,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and current treatments exhibit limited efficacy against advanced HCC. The majority cancer-related deaths are caused by metastasis from primary tumor, which indicates importance identifying clinical biomarkers for predicting indicating prognosis. Patient-derived cells (PDCs) may be effective models biomarker identification. In present study, a wound healing assay was used to obtain 10 fast-migrated...
Glioma is the most primary central nervous system tumor in adults. The 5 year survival rate for glioma patients remains poor, although treatment strategies had improved past few decades. cumulative studies have shown that circular RNA (circRNA) associated with process, so purpose of this study to clarify function circPOSTN glioma.The expression levels circPOSTN, miR-361-5p, and targeting protein Xenopus kinesin-like 2 (TPX2) were assessed real-time quantitative polymerase chain reaction...
Tight regulation of gene expression is achieved through the coordinated action transcription factors and cofactors that often can act as both repressors activators in response to regulatory signals, with their activity modulated by context-specific signal transduction pathways also impinge on transient cyclical recruitment chromatin. However, mechanisms underlying intricate interplay between strategies controlling cofactors’ localization across subcellar domains remain poorly understood....
Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there no on its role in the sensitivity of cells to DDP. RNA expression circ_0007841, microRNA-532-5p (miR-532-5p) and nuclear factor I B (NFIB) was detected by quantitative real-time polymerase chain reaction patient samples cell lines. Protein checked Western blotting analysis. Cell viability, proliferation, apoptotic...
Traditional Chinese medicine (TCM) has been practiced in the treatment of bone diseases and alcoholism. Chronic excessive alcohol use results alcohol-induced diseases, including osteopenia osteoporosis, which increases fracture risk, deficient repair, osteonecrosis. This preclinical study investigated therapeutic effects TCM herbal extracts animal models chronic consumption-induced osteopenia. (Jing extracts) were prepared from nine medicines, a combinative formula for antifatigue immune...
The coexisting post-translational modifications (PTMs) on histone H3 N-terminal tails were known to crosstalk between each other, indicating their interdependency in the epigenetic regulation pathways. H3K36 methylation, an important activating mark, was recently reported antagonize with PRC2-mediated H3K27 methylation possible mechanism during transcription process. On basis of our previous studies, we further integrated RP/HILIC liquid chromatography MRM mass spectrometry quantify PTMs...
G Protein Suppressor 2 (GPS2) is a multifunctional protein that exerts important roles in inflammation and metabolism adipose, liver, immune cells. GPS2 has recently been identified as significantly mutated gene breast cancer other malignancies proposed to work putative tumor suppressor. However, molecular mechanisms by which prevents development and/or progression are largely unknown. Here, we have profiled the phenotypic changes induced depletion MDA-MB-231 triple negative cells...
Astrocytes are the most abundant glial cells in central nervous system; they participate crucial biological processes, maintain brain structure, and regulate system function. Exosomes cell-derived extracellular vesicles containing various bioactive molecules including proteins, peptides, nucleotides, lipids secreted from their cellular sources. Increasing evidence shows that exosomes a communication network system, which astrocyte-derived play important roles. In this review, we have...