A5101524072- Extracellular vesicles in disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Circular RNAs in diseases
- Bone health and treatments
- Membrane Separation and Gas Transport
- Bone Metabolism and Diseases
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Vitamin D Research Studies
- Neuroendocrine Tumor Research Advances
- Mesenchymal stem cell research
- Effects of Radiation Exposure
- Catalysis and Hydrodesulfurization Studies
- Parathyroid Disorders and Treatments
- Management of metastatic bone disease
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
Qingdao Institute of Bioenergy and Bioprocess Technology
2025
Chinese Academy of Sciences
2025
Hua Medicine (China)
2024
Xinjiang Medical University
2024
Zigong First People's Hospital
2022-2024
Wuhan University
2017-2024
Renmin Hospital of Wuhan University
2024
Shandong First Medical University
2024
Taiyuan University of Technology
2024
Shandong Normal University
2024
Abstract There is no effective method to predict chemotherapy response and postoperative prognosis of colorectal cancer liver metastasis (CRLM) patients. Patient‐derived organoid (PDO) has become an important preclinical model. Herein, a living biobank with 50 CRLM organoids derived from primary tumors paired metastatic lesions successfully constructed. PDOs the multiomics levels (histopathology, genome, transcriptome single‐cell sequencing) are comprehensively analyzed confirmed that this...
Tissue sampling of biliary tract carcinomas (BTCs) for molecular characterization is challenging. The aim this study was to investigate the possibility identifying individual actionable mutations derived from bile cell‑free DNA (cfDNA) using targeted deep sequencing. Ten BTC patients, four with gallbladder and six cholangiocarcinomas, were enrolled in present study. Using sequencing a panel 150 tumor‑related genes, paired cfDNA tumor analyzed mutational variants individually then compared....
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and current treatments exhibit limited efficacy against advanced HCC. The majority cancer-related deaths are caused by metastasis from primary tumor, which indicates importance identifying clinical biomarkers for predicting indicating prognosis. Patient-derived cells (PDCs) may be effective models biomarker identification. In present study, a wound healing assay was used to obtain 10 fast-migrated...
Organoids are three-dimensional structures that closely recapitulate tissue architecture and cellular composition, thereby holding great promise for organoid-based drug screening. Although growing in provides the possibility organoids to main features of corresponding tissues, it makes incommodious imaging two-dimensional identifying surviving from surrounding dead cells after being treated by irradiation or chemotherapy. Therefore, significant work remains establish high-quality controls...
Brain metastasis, with the highest incidence in patients lung cancer, significantly worsens prognosis and poses challenges to clinical management. To date, how brain metastasis evades immune elimination remains unknown.
Abstract Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not well understood. To investigate this, we performed multiregion sampling whole-exome sequencing (MRS-WES) on samples from 10 patients who had received prior treatment for PanNETs. This included 29 primary tumor samples, 31 lymph node metastases, 15 liver metastases. We used...
Bone-related complications are commonly reported in cancer patients receiving radiotherapy and collectively referred to as the abscopal effect of irradiation, mechanism which remains poorly understood. When receive targeted a tumor, local skeleton is exposed radiation, particularly within bone marrow. We therefore investigated hypothesis that single irradiation can induce deterioration outside radiation field mediated by marrow.Using 4-month-old male Sprague-Dawley rats, effects (20 Gy,...
Abstract Adding irinotecan to neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC) increases the pathologic complete response (pCR) rate but brings more toxicities. Robust biomarkers predict irinotecan‐based nCRT are extremely necessary for selecting right patients. Our previous study suggests that patient‐derived tumor organoids (PDTOs) sensitivity matches patient responses. In this study, we investigated whether PDTOs can (CR) and survival. Eligible patients...
Plasma cell-free DNA (cfDNA) fragmentomics has demonstrated significant differentiation power between cancer patients and healthy individuals, but little is known in pancreatic biliary tract cancers. The aim of this study to characterize the cfDNA biliopancreatic cancers develop an accurate method for detection. One hundred forty-seven with 71 non-cancer volunteers were enrolled, including 55 cholangiocarcinoma, 30 gallbladder cancer, 62 cancer. Low-coverage whole-genome sequencing (median...
BackgroundDachshund homologue 1 (DACH1) is highly expressed in LGR5+ intestinal stem cells and colorectal tumours. However, the roles of DACH1 cell stemness tumorigenesis remain largely undefined.MethodsWe used immunohistochemistry, western blotting quantitative real-time PCR to analyse expression cancer (CRC) samples. CRISPR/Cas9 gene editing lentiviral vector-mediated overexpression shRNA-mediated knockdown were utilized modulate lines organoids. An organoid-based functional model was...
The identification of indeterminate pulmonary nodules (IPNs) following a low-dose computed tomography (LDCT) is major challenge for early diagnosis lung cancer. inadequate assessment IPNs' malignancy risk results in large number unnecessary surgeries or an increased cancer metastases. However, limited studies on non-invasive IPNs have been reported.In this study, we identified and evaluated the diagnostic value circulating small extracellular vesicle (sEV) microRNAs (miRNAs) patients with...
SIMILAR TO RCD ONE (SRO) gene family is a small plant-specific responsible for growth, development, and stress responses. In particular, it plays vital role in responding to abiotic stresses such as salt, drought, heavy metals. Poplar SROs are rarely reported date. this study, total of nine SRO genes were identified from Populus simonii × nigra, which more similar dicotyledon members. According phylogenetic analysis, the PtSROs can be divided into two groups, members same cluster have...
Checkpoint blockade combined with chemotherapy has become an important treatment option for lung cancer patients in clinical settings. However, biomarkers that effectively identify true responders remain lacking. We assessed the potential of plasma small extracellular vesicle (sEV)-derived microRNAs (miRNAs) as predicting and identifying to immunochemotherapy. A total 29 adenocarcinoma who received pembrolizumab pemetrexed carboplatin were enrolled. The efficacy evaluation revealed 24...
To promote bone formation is one of the fundamental strategies in osteoporosis treatment and fractures repair. As stimulators on formation, osteogenic growth peptide (OGP) increases both proliferation differentiation osteoblasts vitro vivo, which osteoprotegerin (OPG) has been suggested being involved. In this study, we evaluated effects OGP marrow mesenchymal stem cells (MSCs) from OPG-deficient mice by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, alkaline phosphatase...
Objective: This study aimed to assess the clinical value of modified albumin-bilirubin (mALBI) grade in predicting survival patients with advanced non-small cell lung cancer (NSCLC) treated immunotherapy. Methods: We conducted a retrospective cohort NSCLC who received immune checkpoint inhibitors (ICIs) from January 2020 May 2022. The primary endpoints were overall (OS), treatment response, and association between different mALBI grades survival. Results: In these 67 patients, 85.1% (57/67)...
Zeolitic imidazolate framework‐8 (ZIF‐8) with high stability and porosity is a promising candidate for hydrogen separation membranes. However, most ZIF‐8 polycrystalline membranes exhibit low H2/CO2 (kinetic diameters of 2.9/3.3 Å) mixed gas selectivity, due to the intercrystalline defects unprecise molecular sieving originated from framework flexibility structure theoretical aperture size 3.4 Å. Here, inspired by nacre’s “brick‐and‐mortar” structure, we develop matrix type composite in...
Zeolitic imidazolate framework‐8 (ZIF‐8) with high stability and porosity is a promising candidate for hydrogen separation membranes. However, most ZIF‐8 polycrystalline membranes exhibit low H2/CO2 (kinetic diameters of 2.9/3.3 Å) mixed gas selectivity, due to the intercrystalline defects unprecise molecular sieving originated from framework flexibility structure theoretical aperture size 3.4 Å. Here, inspired by nacre’s “brick‐and‐mortar” structure, we develop matrix type composite in...